<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09519

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMQEDRQQEPYFLRAKLLEAVDAEYNVKDMSLILEVLGKLEVLPVTKEILESTRLGKTVNEFRRKVNDPLLAKRLKALVKKWRDAVLTDEPPRNHVTVNGTSSKVSERPGGNRHLPTLTSGYTSASSSPTLASSSRVSPAGSYNSNSLSPRIGTVTNHSNNTSVNSLAANRNGSSSIASRSPNHRNLQLPASSHVTLVSPSASTASPLLNSRHLVSPHKSRSPGGPSLSVFNSHTSNLSPLPSSHYQSSTTSSYAPNAETVSRTNAANKRYRELDDSPLSASTEPPAKKSRSGVNGTLDDPLLALDDISRDSYASRGSDHSDGFTSKDNRFSVSVPSPAALSQASVHSPSIPATGIDSNVPSPANLFDTETANISQINSQPKKKRRKKQTEDINDAIRAKIVQAQAEKAAKAARELEIQNKDKESVSVNPELVETRRRYIEGLAPEDKLANNVIVETYLKSQNELQVKMERDILARRDRAESDFKGADEGTLNQRGVSVDKSKGFSKKEKKKHKKKHDEATEDISNANPFPSEAEILSKLPPLDPEILKEFANYEYDVTLSPLQPDGDSNNTNNRETESTNNLKSLSTIEVKPPKKIDWGDSDDEDDTHGNDGKSDVVLSQQVPVALESSVDISGSQIIGSEDITDYNKVDLEPTPVREVNDADIESYIKDEVPNLNGNHDKDGQFREWHETLTVESYKSEPLHILPYTIIDF
Length712
PositionUnknown
OrganismOrchesella cincta (Springtail)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Collembola> Entomobryomorpha> Entomobryoidea> Orchesellidae> Orchesellinae> Orchesella.
Aromaticity0.04
Grand average of hydropathy-0.796
Instability index56.47
Isoelectric point5.88
Molecular weight78106.22
Publications
PubMed=27289101

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09519
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.92|      22|      24|     121|     144|       1
---------------------------------------------------------------------------
  121-  143 (35.33/18.18)	YTSASSSPTlASSSRVSPAGSYN
  277-  298 (26.59/ 6.10)	PLSASTEPP.AKKSRSGVNGTLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     101.53|      22|      24|     299|     320|       2
---------------------------------------------------------------------------
  166-  184 (21.04/ 6.03)	...LAANR...NGSSSIA..SRSPNHR
  224-  238 (22.40/ 6.82)	GPSLSV..........FN..SHTSNLS
  299-  320 (36.65/15.13)	DPLLALDD...ISRDSYA..SRGSDHS
  321-  347 (21.43/ 6.25)	DGFTSKDNrfsVSVPSPAalSQASVHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     225.55|      47|     210|     348|     394|       3
---------------------------------------------------------------------------
  348-  394 (79.58/43.78)	PSIPATGIDSNVPSPANLFDT....................ETAN....ISQINSQPKKKR.....RKKQ...TEDIND
  415-  483 (39.13/17.89)	LEIQNKDKES.VSVNPELVETrrryieglapedklannvivETYL....KSQNELQVKMERdilarRDRA...ESDF..
  485-  525 (42.77/20.22)	......GADEGTLNQRGVSVD....................KSKG....FSK...KEKKKH.....KKKHdeaTEDISN
  561-  606 (64.07/33.86)	PLQP.DG.DSN...NTNNRET....................ESTNnlksLSTIEVKPPKKI.....DWGD...SDDEDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.01|      10|      15|     196|     206|       4
---------------------------------------------------------------------------
  196-  206 (14.68/ 9.01)	LVSPSASTaSP
  213-  222 (20.33/ 8.81)	LVSPHKSR.SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.87|      17|      17|      49|      65|       5
---------------------------------------------------------------------------
   49-   65 (27.67/18.36)	LESTRLGKTVNEFRRKV
   69-   85 (24.87/15.76)	LLAKRLKALVKKWRDAV
   89-  104 (22.33/13.39)	.EPPRNHVTVNGTSSKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.42|      28|      29|     643|     671|       6
---------------------------------------------------------------------------
  643-  671 (42.96/31.56)	ITDYNKVDLEPTPVREVNDA.DIESYiKDE
  672-  700 (46.46/29.56)	VPNLNGNHDKDGQFREWHETlTVESY.KSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09519 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DITDYNKVDLEPTPVREVNDADIESYIKDEVPNLNGNHDKDGQFREWHE
2) RRDRAESDFKGADEGTLNQRGVSVDKSKGFSKKEKKKHKKKHDEATEDISNANPFPSEAEILSK
3) TDEPPRNHVTVNGTSSKVSERPGGNRHLPTLTSGYTSASSSPTLASSSRVSPAGSYNSNSLSPRIGTVTNHSNNTSVNSLAANRNGSSSIASRSPNHRNLQLPASSHVTLVSPSASTASPLLNSRHLVSPHKSRSPGGPSLSVFNSHTSNLSPLPSSHYQSSTTSSYAPNAETVSRTNAANKRYRELDDSPLSASTEPPAKKSRSGVNGTLDDPLLALDDISRDSYASRGSDHSDGFTSKDNRFSVSVPSPAALSQASVHSPSIPATGIDSNVPSPANLFDTETANISQINSQPKKKRRKKQTEDINDAIRAK
4) VTLSPLQPDGDSNNTNNRETESTNNLKSLSTIEVKPPKKIDWGDSDDEDDTHGNDGKSDVVLSQ
642
475
87
557
690
538
399
620










Molecular Recognition Features






MoRF SequenceStartStop




1) EILKEFANYEYDVTL
2) VKPPKKI
545
590
559
596