<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09518

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceMFTYYLSTTAEKVAEQWLTEEYMSLVTRIIMHIKDKGSKKHGVMGQPNQQQGPGPGGQMGVPMSGGQTNMGMMNQMNPMTSMSQMGVNVMGQPGMVHQMQQSQLVQQMQPGINQAGQMMGGMNQQQSNQQSQQQHQISQQGQNQMMGQGQMTLGLNQGQIQMQQIQNAQMGNPQMQQQLQMQNVQMQQALMQGNSNQIMMTGGQQQVMMQGNQPQQTMIGGGQPQMMMQGNQPQQQGMMQATSQGQQGVMSGGQQQQSMMQGGPQQQQQQQQQSQGMMSGPPQQSQPGNPQQQQMMQVRGIPNPQMVGNRLMNPNAPNVSNTLTALAHAQQQRKAQQQRPMVSNVDNVPVNVQFSGVPGGAQMQQRPVGSFVPSNSSQGMPSPSPGGINVSGYGFILLLTRNTFVLRSLFYGVLVIWLLRQCLRPQPPPQSTFVNSPGSQNIMHRPPGPGVNVNSLSPFPNSMINVPSPNTNLNTPMPMAPTPSPRNAEEQAYMEKSSKMKKLLEILTNPNQRVSMEILLKCEAALKKMERSQLDPGGVLGPASVSAPTPQPKDQTSPFQQIQDSILLSLKSGASSHTFLRTFRQSVEALTGQPFATPPDPVEQEPEFLYYPDMELSVDIPSVLRRELKIVDNRFKVKVIKNPRSSLSLVIHVSLTESRLPRVPPLKIFIPPDYPDESPSVLDLRSEYGFLNSVARTLKSRLLYLPQRFTVLELLGCWEMSVRQVCNPNYKSTAASRKKLSNSLALAFL
Length749
PositionTail
OrganismOrchesella cincta (Springtail)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Collembola> Entomobryomorpha> Entomobryoidea> Orchesellidae> Orchesellinae> Orchesella.
Aromaticity0.04
Grand average of hydropathy-0.571
Instability index63.86
Isoelectric point9.77
Molecular weight82678.00
Publications
PubMed=27289101

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP09518
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.59|      25|      25|     244|     268|       1
---------------------------------------------------------------------------
   37-   56 (33.81/ 6.74)	GSKKHGVM.GQ.P...N......Q.QQGPGPG
  203-  220 (36.39/ 7.93)	GQQQ.VMMQG......N......QPQQT.MIG
  221-  252 (42.42/10.71)	GGQPQMMMQGNqPQQQGmmqatsQGQQGVMSG
  253-  280 (48.96/13.73)	GQQQQSMMQGG.PQQQQ...qqqQQSQGMMSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     395.08|      75|      83|     302|     384|       4
---------------------------------------------------------------------------
  143-  201 (97.13/25.10)	NQMMGQGQM..............T..L.GLNQG....QIQMQQIQNAQM.............GNP.Q.MQQQLQMQNV....QM...QQ....ALMQGNSNQIMMT.
  309-  383 (131.62/46.22)	NRLMNPNAPNVS..........NT..LTALAHA....QQQRKAQQQRPM............VSNVDN.VPVNVQFSGVPGGAQM...QQRPVGSFVPSNSSQGMPSP
  385-  460 (74.33/18.29)	.....PGGINVSgygfillltrNTfvLRSLFYGvlviWLLRQCLRPQP.....................PPQSTFVNSPGSQNI...MHRPPGPGVNVNSLSPFP..
  461-  550 (92.01/21.80)	NSMINVPSPNTN.........lNT..PMPMAPT....PSPRNAEEQAYMeksskmkklleiLTNPNQrVSMEILLKCEAALKKMersQLDPGGVLGPASVS..APTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.75|      40|      72|     598|     637|       5
---------------------------------------------------------------------------
  598-  637 (70.16/42.66)	PPDPVEQEPEFL.YYPDMELSVDIPSVLRRELKIVDNRFKV
  671-  711 (64.59/38.72)	PPDYPDESPSVLdLRSEYGFLNSVARTLKSRLLYLPQRFTV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09518 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ERSQLDPGGVLGPASVSAPTPQPKDQTSPFQQI
2) KGSKKHGVMGQPNQQQGPGPGGQMGVPMSGGQTNMGMMNQMNPMTSMSQMGVNVMGQP
3) NQGQIQMQQIQNAQMGNPQMQQQLQMQNVQMQQALMQGNSNQIMMTGGQQQVMMQGNQPQQTMIGGGQPQMMMQGNQPQQQGMMQATSQGQQGVMSGGQQQQSMMQGGPQQQQQQQQQSQGMMSGPPQQSQPGNPQQQQMMQVRGIPNPQMVGNRLMNPNAPNVSNTLTALAHAQQQRKAQQQRPMVSNVDNVPVNVQFSGVPGGAQMQQRPVGSFVPSNSSQGMPSPSP
4) PPPQSTFVNSPGSQNIMHRPPGPGVNVNSLSPFPNSMINVPSPNTNLNTPMPMAPTPSPRNAEEQAYME
5) QMQQSQLVQQMQPGINQAGQMMGGMNQQQSNQQSQQQHQISQQGQNQMMGQGQMTL
530
36
156
427
98
562
93
385
495
153










Molecular Recognition Features






MoRF SequenceStartStop




1) PEFLYY
606
611