<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09510

Description Cyclin-dependent kinase 8
SequenceMMDYEFKVKTAAERVKVEDWFDYEGCKVGRGTYGHVYKARRKDGVPNPTNGRNDNRDYALKQIEGTGLSMSACREIALLRELKNPNVICLQKVFLSHVDRKVWLLFDYAEHDLWHIIKYHRAAKASKKSVMVPKGMVKSLLHQILQGIHYLHDNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPLEKEWEDIRKMPEHPTLLKDFKRTNYANCSLIKYMDRHKIKPESKAFLLLQKLLLMDPTKRITSEQALMDPYFNEDPVPTSDVFAGCPIPYPKREFLTDDDQVKEEKTENKMQQRPQQTQQNVQNQQQNQVHQQQQGQNQGTYKSVSQSVVLGSNNGPSDPKRIRMGQPHQGHNQSGMDQNNSGQQSGHGHQGQNQGGGHSGGGYMNSGQHHQGQQQQHQNHGQAGGHMHPSGNSMMHQHYHQQNQNHQNQNQNQGFGQRF
Length532
PositionKinase
OrganismOrchesella cincta (Springtail)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Collembola> Entomobryomorpha> Entomobryoidea> Orchesellidae> Orchesellinae> Orchesella.
Aromaticity0.08
Grand average of hydropathy-0.877
Instability index44.06
Isoelectric point8.97
Molecular weight61135.31
Publications
PubMed=27289101

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09510
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.81|      18|      18|     458|     475|       1
---------------------------------------------------------------------------
  437-  454 (33.11/10.68)	MGQPHQGHNQSGMDQNNS
  458-  475 (38.70/13.40)	SGHGHQGQNQGGGHSGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.34|      17|      84|     396|     412|       2
---------------------------------------------------------------------------
  377-  392 (23.47/ 8.95)	EK...TENKMQQRPQ.QTQQ
  396-  412 (35.50/17.47)	NQ...QQNQVHQQQQGQNQG
  478-  494 (31.81/14.86)	NS...GQHHQGQQQQHQNHG
  509-  527 (26.56/11.14)	HQhyhQQNQNH.QNQNQNQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.40|      25|      40|     111|     138|       4
---------------------------------------------------------------------------
  111-  138 (36.83/39.72)	HDLWhIIkyHRAAKASKKSVM...VPKGMVK
  152-  179 (42.57/30.65)	HDNW.VL..HRDLKPANILVMgegPERGRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.38|      37|      86|     235|     272|       5
---------------------------------------------------------------------------
  183-  225 (34.69/18.64)	....MGFarlfnsPL...kPLADLDPVvvtFWYRAPELLLGARHYTKAID
  226-  262 (60.40/34.94)	IWAI.GC......IF...aELLTSEPI...FHCRQEDIKTSNPYHHDQLD
  264-  297 (40.29/24.55)	IFNVMGF......PLekewEDIRKMPE...HPTLLKDFKRTN.Y......
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09510 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) REFLTDDDQVKEEKTENKMQQRPQQTQQNVQNQQQNQVHQQQQGQNQGTYKSVSQSVVLGSNNGPSDPKRIRMGQPHQGHNQSGMDQNNSGQQSGHGHQGQNQGGGHSGGGYMNSGQHHQGQQQQHQNHGQAGGHMHPSGNSMMHQHYHQQNQNHQNQNQNQGFGQRF
365
532










Molecular Recognition Features






MoRF SequenceStartStop




1) DPKRIRMGQ
2) GYMNS
3) MMHQHY
4) QAGGH
431
475
507
495
439
479
512
499