<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09494
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MLRPQHPHGGAGSVSLHPNLTGGGLGTTAGSRAPQTSLVDGLDPVAENLQKIKAAISGLLQYIETQPDSLSWPTIMDRFSTISSQLANLSKIVKSERIPDMRRMDVIPFLVSAETDPGLEKTTEGRIPVMSHDKFPDYFRSKMEPEVEHRFQEAYYKVPPNNAELSQKADKQVQNLNKVVSALVESLSAAKEAWESKTAGLSKIPLTHDVNDTNALLLAMTTGKGLISPPGSSNAYPKYQPGFPGAGGQASQNR |
Length | 254 |
Position | Head |
Organism | Ramazzottius varieornatus (Water bear) (Tardigrade) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Tardigrada> Eutardigrada> Parachela>
Hypsibioidea> Ramazzottiidae> Ramazzottius.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.456 |
Instability index | 38.24 |
Isoelectric point | 7.03 |
Molecular weight | 27430.71 |
Publications | PubMed=27649274
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Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP09494
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.32| 14| 16| 11| 25| 1
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11- 25 (20.86/15.73) AGSVSLHPNLTgGGL
29- 42 (24.46/13.31) AGSRAPQTSLV.DGL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 135.87| 45| 115| 46| 100| 2
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46- 100 (67.39/60.85) AENLQKIKAAISGLLQYIETQPDSLS.....WptimdrfstiSSQLANLSKIVKSERIPD
163- 212 (68.48/42.29) AELSQKADKQVQNLNKVVSALVESLSaakeaW..........ESKTAGLSKIPLTHDVND
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