<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09489

Description Uncharacterized protein
SequenceMSSLDNNGGTSWTGTTWKRPLKKARLGPPDVYPQDTKQREDELSAVTLKQGFIYAPVSLDEYGSVRSSASHVPAGQVSAYFASLLTKRQELNVLQDSSKKRTLFTNKDNFFPAAQAKSNGAVKASFDAVFKELHVSRPANPLPKRIPLFNKKEEVVLACYDYNVPYVKAAWFMKLLAAHAALQTDVKVKKRQVNDPTLEWTMALLKCLKDVLQKLSDCYRLTATEKNEGSNNGAAAGALALQTGATSGASADYDSSSKQWKYCFGLLQHLYEEALIDRHEVCSWLVETMEMARLKGDGGLLKLVAPSVLKFTADIFQSEMLTRKLVSSCSRYLHSICGRKSPKSPLQLLEEALECSHHSVPVTICISIVQLAVVNCSSACLWLLNLNEESSASRHSAGNGNSMAWSNEGSPLDVPLPLPSEMPLTPSLATNDPHLLQKLKDKEEELCQRSAAVEGRWANPKITADENKMHNVWLLVRTLEALDRYAFHKSDGKDNLDKLYKAIKELLSTADASCETSLSVWRQEVEALVRLLCQWSVSTRRSGLHRGMVIGLLLERLQGDVAAHWKTRHNQQEGQPLYLFQDCLMRYLDQEAAQHIKGLDASPDSPPFLNILLLFTELVNHHLFSHDLYVRALIASGLISQPPVAPRPPPPPPQYNPPQHAMMPQHNLMEHGGHDNNPGGYYGMTSTVSPKVAPGASLYSFEQGGPSMSAYGGMSSSLPSPMAAPLYPPPSRQWPQPHANMVPPPPPPLYSSQGISSSYSASQADYLTSDLSLLDGYDEKPASVSSMTSEGAASTSQPSSHGKFNPHRTFLLHLPIGRKQEGQDQEMKDHEMKQRSILLYGVGRARQEAKDQVRRLTKEMKKLLSKKRCYDVSDASRLKSPKALGQTCAQLRHRFRQLPVFDRQQINNEVMPALDNALKALLNGNSNYMPALETVTCILEQSEAALDVGQLLQRVIDILNHVKSIEALLVSRQLGGLAAAILPSVTLHCVGLLRKYHNCLVLSSERTAVAFDALRLIVANSGFMVGQCSSTERCVLACMYDLYQCCSMLQSRYTDFHTASRSISSIIMKKTKPATKGETWDAAFMSEYLQDLSRRPGADTIKRLGEPLGQHSFVVNTLIAVCRSQGSLDEADRLNEMAHLCAEMTASCIGLTAEWLAAFQALCLQFTFNKTIPYSDLLEVVKGYLGDKCVQERLAIFCCILVARHCIRLEDFIGYVAIVTLMAASRHATGDENGGRLVAHIMLRLLRGWHGPPEEGQGAMPVFYLKYPWDRALLASARRDLGVAPLLAVLKAMLVLSESAGGQSLKNGQGSSASVKREALDGDEVPLCPSVQQPIGYDIAGLADFARMALREICQEEVARELVLKELENLFSLDLLLDPIMVVQQTRHLVHLICYPPQAAATFAEERPDNPMYIMHRILHSLDQWNIRICWVELQLMLEPPITGQSATGPNPSPQETAARTAEHNTMVETFGRAVIEAFQLKSGGGDSASGQPAHHLGHVKKGKAQSILRYEVDSGQHTWYIAALVAKLHVPVQHKVLKHIMAVIDKHPLSFRPKERDKMAQSSLLLACPPFISLMSTCMGEVPEVGKAAQGAKQQGNPESWALKENVLRAIHGQLLRLVEEEVRAAVAPTAEERSRATLCQAISLRLSVVGSLFDCIQKRSHLALEWAVLLGQLIISGCVDPAHSTPPVFDLVFDMLTVLTHNLLAFDSLVLSQTSPGSAGQGEAKASTSASATLGNEERKLYPSLVKRLRKDIGEKKTAGILHIRSLLPMAKKNLDVLTVEAYGTTTDAKGNKVVPFGAVNDKRLHLLQALHKVQLNPWEIMEGFRNIQPLCWSFFGAVRLERRVPSLEVNRYLMAWHTHGGAKALAYYMEAPPIPLAIQQEEAASLLGDSEPAVSETTSLDTASPRSPRSARPAKNKRASVSQAAAGPPKKRQTKSPAALGTSHFPTSNMQLGAAGHLMTTGNPVYAGAAEALPQPISWYNGAAGPAPHLMPASQQVQLAGHAHLGGQPAMHLPQQPPPARMMATSYNAAAAAMPASLGPAPSSYSLQQQQQQNRRMAAHLGARSNLQNLIIARQNQSNMQGQSVQQQQNPTLNYMLSAQGPSINTAQQQQMQVEAHRNLALQQQQQQQQQQGGQMPAMNPQMAHGQVQPPAGAATAYGQMPARTPQAVLQQLQQRYPSMTPQQQQDFIMHLRQSQQQRRQQVQQQQQQQQQQQQQQQQQQQQQQQQQAQQPQQRYYPPSQQQAVQYLSGPSPVPPPPAQFQPPDQRQQMFMHQQQQQPQAQQMYGQQNQQQQQR
Length2298
PositionKinase
OrganismRamazzottius varieornatus (Water bear) (Tardigrade)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Tardigrada> Eutardigrada> Parachela> Hypsibioidea> Ramazzottiidae> Ramazzottius.
Aromaticity0.06
Grand average of hydropathy-0.352
Instability index61.29
Isoelectric point8.74
Molecular weight253455.96
Publications
PubMed=27649274

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09489
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     203.16|      22|      22|    2124|    2145|       1
---------------------------------------------------------------------------
 1982- 2003 (24.56/ 8.06)	WYNGAA..GPAPHLMP....A.SQQvQLA
 2131- 2153 (37.66/17.97)	QQQQQG..GQMPAMNPQ..mA.HGQ.VQP
 2154- 2178 (25.59/ 8.83)	PAGAATayGQMPARTPQ...AvLQQ.LQQ
 2197- 2211 (25.41/ 8.70)	QSQQQ.........RRQ...Q.VQQ.QQQ
 2212- 2221 (22.92/ 6.81)	QQQQQ..................QQ.QQQ
 2222- 2246 (30.93/12.88)	QQQQQQ..QQQQAQQPQqryY.PPS.QQQ
 2276- 2297 (36.08/16.77)	HQQQQQ..PQAQQMYGQ...Q.NQQ.QQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     191.24|      46|      94|     641|     712|       2
---------------------------------------------------------------------------
  641-  686 (101.22/31.94)	QPPVAPRPPPPPPQYNP........PQHAMMPQHNLMEHGGHDNNPGGYYGMTS
  720-  741 (32.64/27.29)	SPMAAPLYPPPSRQWPQ........P.HANM.......................
  742-  789 (57.38/14.15)	......VPPPPPPLYSSqgisssysASQADYLTSDLSLLDGYDEKPASVSSMTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     289.70|      48|      73|    2008|    2055|       3
---------------------------------------------------------------------------
 1856- 1886 (35.78/ 9.81)	...............................LMAWH...THGGAKALAYYME.APPIPLAI..Q......................QEEA
 1889- 1938 (45.22/14.08)	LLGdsEPAVsettsldtASP....RSPRSAR...PA...KNKRASVSQAAAG.P.PK......K......................RQTK
 1943- 2007 (31.75/ 7.98)	LGT..S...........HFPtsnmQLGAAGHLMTTGnpvYAGAAEA....L..PQPIS......wyngaagpaphlmpasqqvqlaGHAH
 2008- 2055 (86.02/32.54)	LGG..QPAM........HLP....QQPPPARMMATS...YNAAAAAMPASLG.PAPSSYSL..Q......................QQQQ
 2056- 2080 (28.03/ 6.30)	QN............................RRMA..............AHLG.ARSNLQNLiiA......................RQNQ
 2083- 2130 (62.91/22.08)	MQG..Q.SV........QQQ....QNPTLNYMLSAQ...GPSINTAQQQQMQvEAHRNLAL..Q......................QQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.59|      25|      93|     913|     939|       4
---------------------------------------------------------------------------
  913-  939 (35.74/32.87)	ALDnALKaLLNGNSNYMPAL..ETVTCIL
 1010- 1036 (39.85/25.98)	AFD.ALR.LIVANSGFMVGQcsSTERCVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.61|      11|      81|    2181|    2193|       5
---------------------------------------------------------------------------
 2181- 2191 (22.01/13.50)	PSMTPQQQQDF
 2254- 2264 (22.60/ 6.26)	PSPVPPPPAQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     279.94|      95|     277|     797|     902|       7
---------------------------------------------------------------------------
  797-  902 (137.78/102.67)	QPSSHGKFNPH...RTFLLHLpigRKQEGQDQEMKDHE.MKQRSIL...LYGVGRArQEAKDQVRRLtKEMKKLLSK..KRCYDVSdASRLKSPKALgqtCaqLRHRF.RQLPVFD
 1072- 1176 (142.16/76.53)	KPATKGETWDAafmSEYLQDL...SRRPGADTIKRLGEpLGQHSFVvntLIAVCRS.QGSLDEADRL.NEMAHLCAEmtASCIGLT.AEWLAAFQAL...C..LQFTFnKTIPYSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.97|      46|     277|    1376|    1467|       9
---------------------------------------------------------------------------
  325-  371 (75.92/29.25)	LVSSCSRYL.HSIC.........GRKSPKSPLQLLEEALEcSHHSVPVTICISIVQL
 1381- 1436 (75.06/115.00)	MVVQQTRHLvHLICyppqaaatfAEERPDNPMYIMHRILH.SLDQWNIRICWVELQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.59|      14|     276|    1448|    1467|      14
---------------------------------------------------------------------------
   29-   42 (26.81/ 9.57)	PDVYPQDTKQREDE
 1450- 1463 (25.77/17.47)	PNPSPQETAARTAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09489 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISWYNGAAGPAPHLMPASQQVQLAGHAHLGGQPAMHLPQQPPPARMMATSYNAAAAAMPASLGPAPSSYSLQQQQQQNRRMAAHLGARSNLQNLIIARQNQSNMQGQSVQQQQNPTLNYMLSAQGPSINTAQQQQMQVEAHRNLALQQQQQQQQQQGGQMPAMNPQMAHGQVQPPAGAATAYGQMPARTPQAVLQQLQQRYPSMTPQQQQDFIMHLRQSQQQRRQQVQQQQQQQQQQQQQQQQQQQQQQQQQAQQPQQRYYPPSQQQAVQYLSGPSPVPPPPAQFQPPDQRQQMFMHQQQQQPQAQQMYGQQNQQQQQR
2) PSPMAAPLYPPPSRQWPQPHANMVPPPPPPLYSSQGIS
3) SLLGDSEPAVSETTSLDTASPRSPRSARPAKNKRASVSQAAAGPPKKRQTKSPAALGTSHFPTSNMQLGAAGHLMTT
4) SQPPVAPRPPPPPPQYNPPQHAMMPQHNLMEHGGHDNNPGGYYGMTS
5) YDEKPASVSSMTSEGAASTSQPSSHGKFNPHRTFLLHLPIGRKQEGQDQEMKDHEMKQRSIL
1980
719
1888
640
777
2298
756
1964
686
838










Molecular Recognition Features






MoRF SequenceStartStop




1) GTSWTGTTWKRPLKKARL
2) PQQRYYP
9
2235
26
2241