<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09488

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMQHSSQNPDDWRSLEFRTKVVEHIEIVMSRSQQGQSTSAREYEQRLFNQSNTREDYITCIKNFIGKIKGTIPQQNLSQNPGMIGAQPGQQQMGQMPNEMQQQPAMMSQDPQQYQNMLQQQQYQQQQQMQSGQFMSMGAGAAQQGFPQRPAGPGMVGMSQQQRMAGQTVPMGQQPNMAGQYMQGVGMNQQQQQQAAQMAAAGQQRPQMQGAPRPMFPNNMGMGQEMLQQMKRMAPEEQQRFMAQHRQRAEMASAQQYRQGAPMGQQPGQQARFAPGQIPQGAPGMQPRPGMPYPVQTGAGFPSGIPPMTAGGEQPFPSGVMGGKPGGPFPNQTSPGAAGPPSVGPAPSPASQPSQPDYASIKPGDELYTQKWRDLQKYKDRLNAYIAQTATRADNNNMAQKLRALQKIVNDPNQTIPFQTLIACENACKQFFAAQANETGVASPDALSVRTPGQVAGLTPLVATQAPESLIKNDRPSLTAVADSLSNVLTHLEEKEFVTLCHSLASRAPSFLEDDLNLPTVAISPDLDLDLENLEKMYPDAFNTDNTEDISATERERHRVEQSKMLLAWMEEIPYALQMEICTLLSDYDIALDPDMHPDDEIKDDFIYLCCGLKASRNKSSAPPVGVAVPRKYPAIEIDFREMDVSAYDKGPEWKGLKKNLGGLLLNDGAERGCSLSKILRSWDRAVSLTLKQHGLVRLAI
Length700
PositionTail
OrganismRamazzottius varieornatus (Water bear) (Tardigrade)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Tardigrada> Eutardigrada> Parachela> Hypsibioidea> Ramazzottiidae> Ramazzottius.
Aromaticity0.06
Grand average of hydropathy-0.677
Instability index59.30
Isoelectric point5.78
Molecular weight77139.40
Publications
PubMed=27649274

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP09488
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     251.60|      33|      33|     171|     203|       1
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  155-  181 (37.58/10.16)	..VGMS.QQQR....M..AGQ..T...vpmGQ...QPNMAG..QY..M
  182-  216 (47.08/14.67)	QGVGMNQQQQQQAAQMAAAGQ..Q...rpqMQ..gAPR..P..MF..P
  217-  257 (38.96/10.81)	NNMGMGQEMLQQMKRMAPEEQ..QrfmaqhRQ...RAEMASaqQY..R
  258-  295 (41.89/12.20)	QGAPMGQQPGQQAR..FAPGQipQ......GApgmQPRPGM..PYpvQ
  296-  320 (39.80/11.21)	TGAGF....PSGIPPMTAGGE..Q............PFPSG...V..M
  321-  353 (46.30/14.30)	GGKPGGPFPNQTSPGAAGPPS..V......GP...APSPAS..QP..S
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.49|      45|      70|      28|      82|       2
---------------------------------------------------------------------------
   10-   80 (62.36/32.70)	DWrslefrtkvvehieivMSRS.QQGQS.TSAREYEQRLFNQSNtredyitcikNFIGKIKGTIPQQNLSQNP
   81-  103 (42.65/12.43)	G..........................M.IGAQPGQQQM..................GQ....MPNE.MQQQP
  104-  149 (72.47/25.22)	AM................MSQDpQQYQNmLQQQQYQQQQQMQSG..........QFMSMGAGA.AQQGFPQRP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.70|      77|     112|     495|     577|       3
---------------------------------------------------------------------------
  495-  577 (122.33/86.41)	EFVTLCHSL.ASRAPSFlEddlnlPTVAIS.....PDLDLDLENLE.KMYPDAFN....TDNTEDISATERERHRVEQSKMLLAWMEEIPYALQ
  604-  691 (112.37/66.33)	DFIYLCCGLkASRNKSS.A.....PPVGVAvprkyPAIEIDFREMDvSAYDKGPEwkglKKNLGGLLLNDGAERGCSLSKILRSWDRAVSLTLK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.66|      26|      28|     369|     394|       4
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  369-  394 (46.85/30.71)	QKWRDLQKYKDRLNAYIA.QTATRADN
  399-  425 (41.82/26.65)	QKLRALQKIVNDPNQTIPfQTLIACEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.66|      11|      37|     438|     450|       5
---------------------------------------------------------------------------
  438-  450 (15.05/18.84)	TGVAspDALS.VRT
  478-  489 (14.61/ 8.31)	TAVA..DSLSnVLT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09488 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KGTIPQQNLSQNPGMIGAQPGQQQMGQMPNEMQQQPAMMSQDPQQYQNMLQQQQYQQQQQMQSGQFMSMGAGAAQQGFPQRPAGPGMVGMSQQQRMAGQTVPMGQQPNMAGQYMQGVGMNQQQQQQAAQMAAAGQQRPQMQGAPRPMFPNNMGMGQEMLQQMKRMAPEEQQRFMAQHRQRAEMASAQQYRQGAPMGQQPGQQARFAPGQIPQGAPGMQPRPGMPYPVQTGAGFPSGIPPMTAGGEQPFPSGVMGGKPGGPFPNQTSPGAAGPPSVGPAPSPASQPSQPDYASIKPGDE
68
365










Molecular Recognition Features






MoRF SequenceStartStop




NANANA