<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09480

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAMMQDGGIVNLTGAVSSNAPKTIRLLDMIDTLIQKSYHDLVVLAEVELNRGTTSDMDKKIAIMKYLSRTRNYFIRFLALLEWSSSMSKVEKCFQIVDYLEEQSGVFVETADVLVRMARETLANSKLPCYQVAFAVDVLNSRTCPRMPSCIREKIVPVQPLTQQEKEETLRELEYVLLNRLVTFDRPPPQMRNFVIRRGRVVFIVKDEFEVAMTVLGDDRTMPFRILTLKFLVKNRRVGEGRPLVHAQQVGYLIQLLQSRIMDNEKPLDEVYLFLHTFSQNLQMEVLHTQLTRHMAGGRLDCFRTEKYIPGREIKISYWEDISTKTLSAPRGYTITLTATDRGITIAHQPLIDADTTLRELDVGSVMMSVIHFRVKSRLSKLQAELSRHFSCSITGFPLLLLVPLYPAALRSHCVQISVDYYTGQFTVQLERLPQKSTHSLRDTLNTFTYKYERLVELLGNLRLELTLELVKASSARTHLQAPTHLALFGGEPFERLNRLGPHKAIFRFQKKIDVTALLVVSVHEDPSVPDGVRVDYHAVLVEQSNLKGMKVLALIDREKLSDGAQYFFREKLNTPAQVITKNPLELLKARLQTMREHRSDGRLPTRSTKLYPAALVDFERTVGSLLTETMFSELQSVLKTRDIPAGPITEVTYGGESPGAPILTLPVRLEHDLNLLRSCTFRRVGKLATTSSASFYVDFLMSGVPFQKGSSTLSCTFSYDSTMSSEKIVEWLSYDWVSMTGLLRLMRRFKAFLDTKPHPPGVKYDVSYNLRKVRVLYGPNLELAVLLSWDRNEKKLVLEFYGQSDGVLNPHRALKDRLLNMIRPKTGSHPVDFSHIFDVLMHTTPLMLGVRESYRPVGVVKIPRSLTPQVTFQFVLISLSQYAVIWKGSFCLWVKILNGPKFLVRDVGSSFTEAKRGEEKVYQPVTGLKAITEAALAGKPLTSSETAGSDQELQQSIYKLFTFLRGYPVQIAGNSS
Length977
PositionTail
OrganismRamazzottius varieornatus (Water bear) (Tardigrade)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Tardigrada> Eutardigrada> Parachela> Hypsibioidea> Ramazzottiidae> Ramazzottius.
Aromaticity0.08
Grand average of hydropathy-0.115
Instability index37.61
Isoelectric point9.33
Molecular weight110913.51
Publications
PubMed=27649274

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09480
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.48|      58|     127|      21|      87|       1
---------------------------------------------------------------------------
   21-   87 (84.32/82.24)	PKTIR..LLDmIDTLIQKSYHD.LVVLAEVELNRGTTsdMDKKIAIMkylsrtRNYFIR.....FLALLEWSSSM
  148-  213 (88.16/60.20)	PSCIRekIVP.VQPLTQQEKEEtLRELEYVLLNRLVT..FDRPPPQM......RNFVIRrgrvvFIVKDEFEVAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.72|      17|      20|     687|     703|       2
---------------------------------------------------------------------------
  687-  703 (29.37/17.84)	KLATTSSASFYVDFLMS
  709-  725 (31.34/19.49)	KGSSTLSCTFSYDSTMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     244.00|      67|     203|     405|     477|       3
---------------------------------------------------------------------------
  405-  477 (101.90/72.40)	LYPAALrshcvqISVDYYTGQFTVQLERLPQKSTHSLRD....TLNTFTYKYER.LVELLG.NLRLELTLELVKASSAR
  559-  603 (50.54/24.62)	..........................EKLSDGAQYFFRE....KLNTPAQVITKnPLELL..KARLQTMRE..HRSDGR
  611-  683 (91.56/53.17)	LYPAAL......VDFERTVGSLLTETMFSELQSVLKTRDipagPITEVTYGGESpGAPILTlPVRLEHDLNLLRSCTFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.25|      31|     119|     734|     782|       4
---------------------------------------------------------------------------
  286-  318 (52.74/23.33)	VLHTQLTRHMAggRLDCF.RTEKYIPGREIKISY
  738-  769 (53.51/49.65)	VSMTGLLRLMR..RFKAFlDTKPHPPGVKYDVSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.66|      50|     699|      91|     147|       5
---------------------------------------------------------------------------
   91-  147 (74.13/76.46)	EKCFqIVDYLEEQSGVFV...ETADVLVRMARetlanSKLPCYQVAFA..VDVLnSRTCPRM
  794-  848 (78.53/57.67)	EKKL.VLEFYGQSDGVLNphrALKDRLLNMIR.....PKTGSHPVDFShiFDVL.MHTTPLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.54|      14|      19|     517|     535|       7
---------------------------------------------------------------------------
  517-  535 (18.33/21.83)	ALLVvsvheDPSVPDGVRV
  539-  552 (23.22/13.18)	AVLV.....EQSNLKGMKV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09480 with Med14 domain of Kingdom Metazoa
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