<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09476
Description |
Mediator of RNA polymerase II transcription subunit 31 |
Sequence | MAALTRGGSSNDVTIMPEDPQKVRFQAELEFVQCLANPHYLNFLAQRGYFKNKNFINYLKYLLYWKQPEYLQFIKYPYCLTFLDLLQHDAFRQQLVNPQWARFIDDQQVLFWQHYTRQKNILLQTTGNQEAATATKPPVQEGQT |
Length | 144 |
Position | Middle |
Organism | Ramazzottius varieornatus (Water bear) (Tardigrade) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Tardigrada> Eutardigrada> Parachela>
Hypsibioidea> Ramazzottiidae> Ramazzottius.
|
Aromaticity | 0.15 |
Grand average of hydropathy | -0.516 |
Instability index | 45.65 |
Isoelectric point | 8.52 |
Molecular weight | 17099.29 |
Publications | PubMed=27649274
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364129
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription, DNA-templated GO:0006355 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP09476
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 91.82| 25| 28| 37| 61| 1
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29- 53 (24.02/ 9.98) .....LEF...vqclaNPHYLNF......LAQRGYFKNK
54- 80 (34.20/16.84) NFINYLKY...llywkQPEYLQF......IK...YPYCL
81- 119 (33.60/16.44) TFLDLLQHdafrqqlvNPQWARFiddqqvLFWQHYTRQK
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