<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09475

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMDIGSLFGALRAAANSMQEIQKKMVITAPTRSTLLDSYDTLIEKYCSANGLRLYKEQVPTAQETLMYYIDTDDFRTDIQIAKDFVEEVWVHHPLKMQPEGCPKMAKALRLKDMMEFHEHMKGLQNMYSLTPERHLRRPLFLCLTNLENDLMSMDQHISQWQMPPLDMVKYSPCGLLVPRSEGKPLRVGFFVAPSDLVERDGSLMRADFVVLGARQIGLWASVTVTAISNAEWLPSTPTFRRVFRSEEGFISCDFAPLEECNPLELSGSFVLTLKEPIIVTDRVSEELEVLTGFPVRTDDTSSQPYLQVLHNQFFTGKSLPHSDAPYKFVIAGQHHAYSLHAPNELTRFVTEVCFAHVSVLPSILNGLRRQATINKLFSGCMRNVAENEIISPFAFDVTYSSPRSLMVEFSHPLDSSPVKVQIGLAENGSPSWAMQQSSPALCTDAAANTWLRKTLSIPVVLRTIIKRFAESYVDEPTKSHTRTAAARPIQQIQKPPLADIQIPPSLIVQHVETLPPIQKTAPSITALLESKSTPPPLLLSANQGRGTKMEKMLMDKKPASRDKTVSPKSMTMDKSEHTKKLKALYETNGKKQSLKTKRKAESFDLDLKPKKRKSMADIASSSHAGSSKSSDSSSSLENELTKPVASPMGRIRIAKSELSPHGSPITIKLIKRESTDSGMQAVIVNKEPPKKKKTKPAGPPEPKKLKKGLLAETPPPPPEVPKKIKREPGVDTPDTPLLVSELKKPKKEVLSDFSFLPEPKPSKFKPELGVLETHLLQSKKGSPNKSPTERKSAPPTPVSNTKVTLIPTKLTAPAAASSPSKSKEGPVRSAHFQPASSRSPVPLSNSPSKSPVPGMASSSAPIFQPPKPPSSIRDLPRIPKKNANAAATPKAASFAVQSLASPLGTHATPAQVAAVYGQLIDKIFAESPTKEALSPAPNVVPFQPPTTQSSLGTIQIQTFPQGLQSGALQENIDKVIAASTAERQPRPNPGLVIDIPPHSDLGDTNKSGTRGSTSSETIASPLVKSRNPTKSLNVLAIVDRLAKQSKSRVDSGPDNSGDSSDVQDSVFKQLTGPSDATDGRQRSDENTTGSAEAAQDRTSTPTKMAMLVQYDDSTDDDTLDETGPRGLKEVKHTVRVEVVSPEIGEPTSFTFRTKPSASAGELGDSLGLDMGKTQPTGAAEIAALTASPPPTDSLLNAPDRTSPVILDDELLDAAFLSPETDDRS
Length1224
PositionMiddle
OrganismRamazzottius varieornatus (Water bear) (Tardigrade)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Tardigrada> Eutardigrada> Parachela> Hypsibioidea> Ramazzottiidae> Ramazzottius.
Aromaticity0.05
Grand average of hydropathy-0.445
Instability index53.70
Isoelectric point8.90
Molecular weight133023.31
Publications
PubMed=27649274

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09475
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.82|      18|      18|     696|     713|       1
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  678-  707 (23.10/ 6.01)	GMQAvivnkeppkkkkTKPAGPPE.PKKLKK
  708-  726 (28.72/ 9.33)	GLLA............ETPPPPPEvPKKIKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.13|      15|      18|     813|     829|       2
---------------------------------------------------------------------------
  813-  827 (25.27/ 6.05)	PAAASSPSKSKEGPV
  834-  848 (22.86/ 6.20)	PASSRSPVPLSNSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.28|      16|      19|    1058|    1076|       4
---------------------------------------------------------------------------
 1058- 1076 (22.18/22.29)	DSSDVQDsvfKQLTGPSDA
 1078- 1093 (27.10/16.98)	DGRQRSD...ENTTGSAEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.76|      19|      19|     489|     507|       5
---------------------------------------------------------------------------
  489-  507 (30.10/12.33)	IQQIQK.PP...........LADIQIPPSLI
  508-  538 (22.66/ 7.21)	VQHVETlPPiqktapsitalLESKSTPPPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.10|      15|      17|     176|     191|       6
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  176-  191 (23.65/19.66)	LVPRsEGKPLRVGFFV
  196-  210 (26.45/16.63)	LVER.DGSLMRADFVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.83|      18|      19|     744|     762|       9
---------------------------------------------------------------------------
  744-  762 (28.36/20.68)	KPKKEVLsDFSFLPEPKPS
  765-  782 (30.47/17.40)	KPELGVL.ETHLLQSKKGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.61|      16|      17|     541|     556|      11
---------------------------------------------------------------------------
  541-  556 (28.25/16.92)	ANQGRGTKMEKMLMDK
  559-  574 (27.36/16.16)	ASRDKTVSPKSMTMDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.78|      18|      19|    1142|    1159|      12
---------------------------------------------------------------------------
 1142- 1159 (30.77/17.16)	EIGEPTSFTF.RTKPSASA
 1161- 1179 (24.02/11.41)	ELGDSLGLDMgKTQPTGAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.09|      18|      20|     853|     870|      13
---------------------------------------------------------------------------
  853-  870 (36.45/16.49)	PGMASSSAPIFQPPKPPS
  876-  893 (25.64/ 9.25)	PRIPKKNANAAATPKAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.53|      21|     201|     976|     996|      16
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  917-  937 (35.98/20.75)	GQL...............................IDKIFAESPTKEALSPAP
  938-  989 (19.55/ 7.55)	NVVpfqppttqsslgtiqiqtfpqglqsgalqenIDKVIAASTAERQPRPNP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09475 with Med1 domain of Kingdom Metazoa
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