<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09461

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTDSSLTNILVVSGVSQIRYRAYSQTCNPTQLLDHLKNKQAHDLTLLKAYYDLTSLSIPTLWQVASVSDEPGKQLTLELWVFWFDERHTGKIDANDYVDALEEIEVGSFTWENAYSAIQSPLSTAGNVSLSNSGVPATLTTKHKLFIQSVRNLVRLEMKRKGALPLGEFYLFPSHPDQQCKQDTPSLLSTSTMLCCSYNLYLTSTNLVFQPNTRRMQIRPIXAKAIRTKGKKVMMSPSGETAWIAFNPYSLSSPTPLSPQTENTILERWAQLFDIPYDHLKFKSGSLPSLIALKKSANDDVFYYPTSLIFLSSSTKLSPTAMAGMNGVFGFNQGYSEDLGDRWYRWAWSEHASNYWDYTCPRDKTTSIVLDILAHDHHHTNSTVLQKALNEPVMSSPLMATKSVVTHYANSRTSLTDLPALEQPEEDTAQRQTRIYDQSGISLVEFAMAHFALPSHNQESDLPDLTMMSTTEYSPQVVLPNQPINTPYMHHGLPMQISTSQQLQQQQQHQQQQHQPPXPQPPPPFHTHTSQTESNQMSGTNTAYQSPHMSNMELDSFGIVESMDVDNMVLDMPNRWTDDGMNDVDNFDFGVTEEDFDFFETSAVAAAAATNNTMPLQSQSIIPPISDTMLIEAQDNLMDPTDQDTMMISSEDLDFSFDEKKPDMDKQSPLEMQTRSVQPLQEETPMDLITHEAPSVDQLYVPPQFAPVKFDFMVNDAKYAQGGKFTYTPTTEDQQMINKKHRKSEDYRPDYVPLVRTKKNKKGNINSRRKSSKLILETIHKENKSLTVPCTHDTDEAIADTEEKTSHNVLTHHYHTSENDSNSHDSSSNSSSSSSSDSDSNSSDSNSDSEEEAEHGVIIDDTITPRGIQSDNESTRSENSQLPEEGPGKTKRIMNALQQAQERYIQQLICLKPLVRQKSLRLEQLVMDYDSPFAQAVVSNTIRPNRNFLDDESEENRFRALDHLCQQAVMGGYPFSGGIEAMSSNGFEANEGESAKVIIARRRNLLQKLNGDAIHLPSTPNDVDFMIQHFKDILGEVFHHQQQQKKQTDTIDPMCLDQLPMPSSVTVKGPLSVQQCYDLSEANQAHSKYGKYQVKKRRPAEPNLDTLQPPTITVNRQEESLEGSSRLIMFWEKLRLEPYSSKKHVAYFVLYPKNESVEAHVTHFFRGLSTLYETCQLGAHLPGNTHTYRKGLVPVPLLAAQHPNESMEDRQLRSYMAECQQLGSSLSSMMNENIHIVIYLINPITHLKSHLDLSLCFHKLMDTYHTSISQHIHKTPHKTPARLVLQLMPIEHVLRSTAFGGCLKFGLKEIAFAVYSKCHTVVHRTSNDPTLSIASMDIYSPPFVLSKPVPTQIPFKLKKAIHAFPTLLEDHPVLHMAYSFSFDRKWMVIVWTDNYGELIEFALLDRRQYKHSIFKEAWSRTKQVSKRTGSAWTFVIAKMGLLFEDELKAWMACFQKKSEEEQDNGLGEEERVAIVSIDIESTFHVNVAAYASRLHELNSGDISAATTPTGNSTTSSTASPISSVPLKKMMDDQGQTKALLLNHRVAYSNRRERMSFGMLNMNPISHIEDWMIPLASGYIIHTPPTTENPNNELFNCDPVVLEIHLIYNQTNHSAYSTLRDIIKKYHALSYINVMPSDSNCFPIHIALVERLCRLLLVIHS
Length1661
PositionKinase
OrganismChoanephora cucurbitarum
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Choanephoraceae> Choanephoroideae> Choanephora.
Aromaticity0.08
Grand average of hydropathy-0.499
Instability index55.50
Isoelectric point5.77
Molecular weight187638.41
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09461
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     279.11|      82|     184|     431|     548|       1
---------------------------------------------------------------------------
  431-  517 (134.00/79.00)	QRQTRIYDQSGISLVefAMAHFALPSHNQeSDLPDL...................TMM........STTEYSPQvvLPNQPINTPYMHHGLPMQISTSQQLQQQQQHQQQQHQP
  594-  694 (103.82/76.89)	EEDFDFFETSAVAAA..AATNNTMPLQSQ.SIIPPIsdtmlieaqdnlmdptdqdTMMissedldfSFDEKKPD..MDKQ...SP.....LEMQTRSVQPLQEETPMDLITHEA
 1017- 1054 (41.30/ 8.74)	............................................................................LPSTPNDVDFMIQHFKDILGEVFHHQQQQKKQTDTIDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.00|      14|      21|     818|     831|       2
---------------------------------------------------------------------------
  818-  831 (26.85/15.36)	SENDSNSHDSSSNS
  837-  850 (26.15/14.76)	SDSDSNSSDSNSDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.36|      42|     634|     853|     902|       3
---------------------------------------------------------------------------
  853-  902 (58.52/53.63)	EAEHGVIIDDTiTPRGiQSDNESTRSENSQLPeegpgkTKRIMNALQQAQ
 1497- 1538 (72.84/42.57)	ELNSGDISAAT.TPTG.NSTTSSTASPISSVP......LKKMMDDQGQTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.41|      25|     188|      56|      86|       4
---------------------------------------------------------------------------
   56-   86 (36.93/40.69)	SLSIPTlwqvaSVSDEPgKQLTLELWVFWFD
  251-  275 (46.47/29.88)	SLSSPT.....PLSPQT.ENTILERWAQLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.76|      28|     634|     696|     731|       8
---------------------------------------------------------------------------
  696-  731 (38.83/43.79)	SVDqLYVPP....QFAPVKFDFMVNDAKYAqggkFtytPT
 1336- 1367 (48.93/28.46)	SMD.IYSPPfvlsKPVPTQIPFKLKKAIHA....F...PT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.69|      55|      89|    1145|    1206|      11
---------------------------------------------------------------------------
 1145- 1206 (81.90/64.28)	HVAYFVLYPKNEsVEAH..VTHFFRGLSTLYETcQLGAHLPGNTHTyrkglVPVPLLAAQHPNE
 1236- 1292 (92.79/52.36)	HIVIYLINPITH.LKSHldLSLCFHKLMDTYHT.SISQHIHKTPHK.....TPARLVLQLMPIE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09461 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAATNNTMPLQSQSIIPPISDTMLIEAQDNLMDPTDQDT
2) ALPSHNQESDLPDLTMMSTTEYSPQVVLPNQPINTPYMHHGLPMQISTSQQLQQQQQHQQQQHQPPXPQPPPPFHTHTSQTESNQMSGTNTAYQSPHMSNMELDSFG
3) GKFTYTPTTEDQQMINKKHRKSEDYRPDYVPLVRTKKNKKGNINSRRKSSKLILETIHKENKSLTVPCTHDTDEAIADTEEKTSHNVLTHHYHTSENDSNSHDSSSNSSSSSSSDSDSNSSDSNSDSEEEAEHGVIIDDTITPRGIQSDNESTRSENSQLPEEGPGKTKRIMNALQ
4) KYGKYQVKKRRPAEPNLDTLQPPTITVNRQE
5) MISSEDLDFSFDEKKPDMDKQSPLEMQTRSVQPLQEETPMDLITHEAPSV
608
453
724
1089
648
646
559
899
1119
697










Molecular Recognition Features






MoRF SequenceStartStop




NANANA