<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09453

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAGRHQSQYTRYTSSNQPYSISNNNSLTVPYPSSQHQQQQQQQQMPSNQSYTTINNTYNTSMSSPYANSPSPGYHSPNLSRSTPQPQLKKYTLQPPRKLPLSKTMPSLGFPGMFPQRAGQDEDILTESNVRHGFMDRPVVSNEHTCAHDIVYGKLQDDQRLLGELGSFMVDVLQRQNRAGLITGPSSFKAPIRTTLSDAKREQWIQDLAGGVVPLRKLARNVPHGFKGEKLLETLASKQVPFLRATWYIKIIGLSEMSQRNASNATTSLGPQPIQWTAIVTGHLKKQLTELLPITNTTATANTTTATNTTTTNASSPHPSTPGRNYRYDTNQSRPWHTPETKQRFEQRWSYSVRLTRWQYFEGLLDQRTFLKWTLDTLASSASFEMMWLVLTGIIQDYVDEYKRNRTLTKLLIETLIKSYSALAQCIHPDESTSLYHGLKQDIEHLLQSLFLSAPDMFVIPKLYYQYRYLFDSILGDTNHLKPLSDVSRVLREYWTMVKARNEVFCGTLEENSLKAEESKATPADPSSITSSPLAPITPMTPTLTVKKSKTISPPPPIPPPSSELGIGSEERIVQLLDDISKNVESVSGLLLDQETWIDVRGHSAKSAVKSIFGSRISSQAFTERVHSMCRWATNQSRYGDDKAYLVGSVLMAWLQQQQGRHYQQSTTVLQDALIRFLDQQIQETENSAVIYLFDVLIRLRLFSYQKYLLRLIARGDLEPKRRNSNQIQHCLHYLAAFPLLSPTPAYLINQRRVALYGTKQESHPSETQTLEHLKHLARMALMGYDRGDTDGLFGTDAQEMTQPLPTDTQRSYELAFEELSPDFQKALESATRYSLLDFTSNWLLDQVKRFVVKSIQIGEDNWRVMTSPGSCLLNTRQFVTLVSIMDHAKDYLSLIDMTLWALEKTSDRTMLPYIIDCLRKYANYWKLTNHGPQVVHAVWSKHAALTSRGNRERCIMMYMVQLVQEGHLLDEVARAQLQHDLQVKYKSRTSPISIRHELSQLIKDASPSSQQMVSEVVCKPAQMHGWIGAILENVGDLLAQESHTVSFQFYRLVRAFAQVLKDVADTTTFTGQADTIVVEWLCRHPTAVQAMHQKGAWVPMFVAVLVAYNVVSLSKIIRDYALLEFERIGQQQQQYDTEDAQSVIFCQNLIIMIRLLVVQLTNKSKYEETMSVLWPLRIEEYFRLQVQRQSQLASSLERIEPMFGLMERLVLIATNLPLSSSLLQDIVMLRADLLQITWFRQTCLRDLNGVYQRFAAREAEAVMEKRIKKKMLNIVDELIGGNNLTNERQQSMLQDSSPDFVDKLHRVFLNVSQWNEAQCRVQVNLLLDNISLSDGHPSNPHILGDDAINMTTSTNTIVPATTGSDIINKDLQSFVYFFYDVVLSDEDHHSKTADVQRRFQFFKNLIHELREPVLLQLLQHSARLLEGDPSQSFPDNVLLMQLTEPGKPFDSAKFAYRSQSFLNITQHMLAENVWTNEKKIEVVKTVFEQIHRFKDGLSIYKVMQDANVCYADAVNALHLVKNNADLAIALLVTEGLPENPTEEMMDDGKKLSLQDIRNSLLVRLRLVVPFASLIWEHPKEDACNILDWIRVLVPLLCNPIVHGNGSQERTFEFTLDFVSLLIDEVPKELKKISLVLLGSMHSELTCIPVMFHSRVKRIMPFLTHNIYLSNTRIASSLLGLPMATDQQQQQQHIDSCLEQSKPWEWLEDYVSDPPHDNDAPINLGLFQARKSKRTDPTYPKWFKFGFGESRSNHISTLDRLKEGRSMLVDDHMIKKRKVEMEEGELP
Length1787
PositionKinase
OrganismChoanephora cucurbitarum
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Choanephoraceae> Choanephoroideae> Choanephora.
Aromaticity0.08
Grand average of hydropathy-0.359
Instability index48.49
Isoelectric point6.93
Molecular weight204102.67
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09453
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.70|      19|      21|      77|      97|       1
---------------------------------------------------------------------------
   79-   97 (34.60/20.77)	LSRSTPQPQLKKYTLQPPR
   99-  117 (36.11/15.15)	LPLSKTMPSLGFPGMFPQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.95|      47|     280|     761|     810|       2
---------------------------------------------------------------------------
  761-  810 (78.38/77.14)	QESHPSETQTLEHLKHLARMAlmgYDRGDTDGLFGTDAQEMTQPL...PTDTQ
 1041- 1090 (74.57/62.55)	QESHTVSFQFYRLVRAFAQVL...KDVADTTTFTGQADTIVVEWLcrhPTAVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.27|      17|      21|     312|     328|       3
---------------------------------------------------------------------------
  312-  328 (35.29/17.77)	TNASSP.H.PSTPGR...NYRY
  330-  351 (21.99/ 8.47)	TNQSRPwHtPETKQRfeqRWSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.06|      65|     153|    1407|    1484|       5
---------------------------------------------------------------------------
 1272- 1351 (68.88/37.86)	MLNIVDELIGGNNLTNERQQSMLqdsspdfvdkLHRvflnvsqwneAQCRVQVNLLLDNISLSDGHPSNPhiL......GDDAINM.........
 1407- 1448 (54.07/29.46)	.................................IHE..........LREPVLLQLLQHSARLLEGDPSQS..F......PDNVLLMQLTE..PGK
 1462- 1540 (86.10/78.21)	FLNITQHMLAENVWTNEKKIEVV....ktvfeqIHR..........FKDGLSIYKVMQDANVCYADAVNA..LhlvknnADLAIALLVTEglPEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.13|      52|     554|    1092|    1143|       6
---------------------------------------------------------------------------
 1092- 1143 (91.00/78.55)	MHQKGAWVP.MF......VAVLVAYNV.VSLSKIIRDYALLEFERIGQQQQQY.DTEDAQS
 1641- 1701 (75.13/63.09)	MHSELTCIPvMFhsrvkrIMPFLTHNIyLSNTRIASSLLGLPMATDQQQQQQHiDSCLEQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.47|      15|     283|     219|     241|       8
---------------------------------------------------------------------------
  200-  214 (27.86/ 8.36)	KREQWIQDLAGGVVP
  227-  241 (24.61/20.70)	KGEKLLETLASKQVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.45|      29|      95|     725|     753|      10
---------------------------------------------------------------------------
  725-  753 (53.21/35.04)	SNQIQHCLHYLAAFPLLSPTPAYLINQ.RR
  821-  850 (46.24/29.36)	SPDFQKALESATRYSLLDFTSNWLLDQvKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.77|      19|      20|     528|     546|      11
---------------------------------------------------------------------------
  528-  546 (35.21/19.65)	SITSSPLAPITPMTPTLTV
  549-  567 (36.56/20.70)	SKTISPPPPIPPPSSELGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.70|      21|      21|     657|     677|      13
---------------------------------------------------------------------------
  657-  677 (36.60/29.31)	QQQGRHYQQSTTVLQDALIRF
  680-  700 (34.10/26.70)	QQIQETENSAVIYLFDVLIRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09453 with Med12 domain of Kingdom Fungi
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