<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09449

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceMHPTMTTSNGTSHLDEPSKDKEKIVLPVEMASMVPLRTLIAKLVHKSYADLLTLTDTLPSMSDVEKKRRILTYSLSVRKQFLKLLVLIKWAENAEDIQMCQNIMAFLANQNKIFQDTVDYLHNIHSKLPAARLRNFDIPTAVDVLTTGTYQRMPTKIKDMMAPVPLSDQEVLETFQNMNDVIRMRMITTEVLPSPMQTYRIENGRIYFTIQNEFEVALTLMGHSHDRRWWIVSLDMLVQATSTGGAAEDVDITLNETQKQHLRVNAQKQLVPPPSMESNSLFFPLVNMYDYLHLCCLNMQLEVLYIQAAMLAKTRWINQLKVQMNPDRTKLTLIYWRGGSHASRWASRSNSDKSTTIEISVNDQEDPEEDYQMAVRDDWHGVIQKAGIGASIHLSELPVQDRSRVLSLLKYPKTTLSVLWDGYELKDHGLDPSDLNLERLVLQTTHDHGACMIDKFRSLLLSQRAFLEENGLFLDTTSTSQLVVRYRHAKYISIDTDTRTGRIKAFEADDGCHEGDFKLRGLEDRLNNDPENIARHLLWLRSEVVVREVIALAKQLNLQPYHPSQMNLRPEDIQKLFGDLVPDGVKEVSYPSHCVFLQFSQFEDWYFCMATVKNQFKSWLCCINKTYDATGLYQTIVDLAHLNSDQLWSGQFKQTSPTMERETLKREIKEEDEKEEGVLPGLKKRRTSRFLLPTKERDEEEDGGEPIKKEEDEKVDRLSIDLRYLAKLDSLCQAYIINRKIESQLQSYKGSLKYHTRPLLKTINRMETQVRNHPAAEKMEVICVSQ
Length786
PositionTail
OrganismChoanephora cucurbitarum
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Choanephoraceae> Choanephoroideae> Choanephora.
Aromaticity0.07
Grand average of hydropathy-0.448
Instability index45.52
Isoelectric point6.13
Molecular weight90746.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09449
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.10|      54|     267|      95|     183|       1
---------------------------------------------------------------------------
  124-  183 (86.94/127.77)	IH.SKLPAA.RLRNFDI...P.TAVDVLTTGtYQrmptkIKDM.MAPVPLS.DQEVLETFQN....MNDVIR
  392-  457 (65.16/32.35)	IHlSELPVQdRSRVLSLlkyPkTTLSVLWDG.YE.....LKDHgLDPSDLNlERLVLQTTHDhgacMIDKFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.75|      14|     165|     109|     122|       2
---------------------------------------------------------------------------
  109-  122 (27.09/16.71)	NQNKIFQDTV...DYLH
  277-  293 (21.66/12.08)	ESNSLFFPLVnmyDYLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.42|      18|      39|     657|     674|       5
---------------------------------------------------------------------------
  657-  674 (33.40/21.38)	PTMER...ETLKREI.KEEDEK
  693-  714 (25.02/14.31)	PTKERdeeEDGGEPIkKEEDEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.05|      28|     325|     294|     321|       6
---------------------------------------------------------------------------
  294-  321 (51.67/37.78)	LCCLNMQLEV..LY...IQAAMLAKTR.WINQLK
  620-  653 (39.37/26.99)	LCCINKTYDAtgLYqtiVDLAHLNSDQlWSGQFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.19|      12|     114|     218|     229|       7
---------------------------------------------------------------------------
  218-  229 (26.64/18.93)	LTLM...GHSHDRRW
  331-  345 (19.55/11.93)	LTLIywrGGSHASRW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09449 with Med14 domain of Kingdom Fungi
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