<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09441

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMQPGQLARAACESVHTDDISLASLTMAQQPQNVMPQDMLQHATQMHHPVNSYYPENNDLTGGLPINLDSLRDGPPGSKPFYPYSTLIRYAIKGAPNQKLLLEDIYYAIESRFPYFRSAPPGWKNSVRHNLSLNPCFEKVPRPLTDRGKGSYWTVNDNVDPRTGVHRVRKKKPKGGAGKQPVAIEEDIDYHPDAGQQPTFDPNVPFVPQPPMGPADAGPSRQAPYPPPYPTYAGPFADLAPRRQIRPRFEIDEHGQVDWHAAWVKELTQLQQATEAQEKTGADQEWYRMMLVRLRSGMMAAPMNPGDPTLHVPGAPPHALTGQPNPGEMSAYVRIYFGAYHHSLLDLYTTFHFKRSLMSSHYYEVALFGEFFSQDLPAIINRITLHSESAHQMHSREIVFEPFDAQHQRDTGTEPVLLRARKELLEPDSKWVLYSYLKPESVRMHPEATVRPWATCQVDGNALSFASALGYVRRSQIFKRGYVFRKGTLVIQMFQQEHVDPKTQKPIPAHADTLWEVEVKTASPIRNTQETPLSQSVDAVLEVQLLMKGLLDLRRQDV
Length557
PositionHead
OrganismGrifola frondosa (Maitake) (Polyporus frondosus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Grifolaceae> Grifola.
Aromaticity0.09
Grand average of hydropathy-0.579
Instability index52.36
Isoelectric point6.90
Molecular weight63034.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364150

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA-binding transcription factor activity	GO:0003700	IEA:InterPro
sequence-specific DNA binding	GO:0043565	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09441
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.74|      15|      15|     209|     223|       1
---------------------------------------------------------------------------
  209-  223 (32.22/14.28)	PPMGPADAGP.SRQAP
  225-  240 (28.53/11.86)	PPPYPTYAGPfADLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.65|      12|      15|     495|     506|       2
---------------------------------------------------------------------------
  495-  506 (22.50/14.48)	QE..HVDPKTQKPI
  511-  524 (15.15/ 7.46)	DTlwEVEVKTASPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.14|      14|      15|     177|     191|       3
---------------------------------------------------------------------------
  177-  191 (22.14/12.05)	GKQPvAIEEDIDYHP
  194-  207 (28.00/12.02)	GQQP.TFDPNVPFVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.79|      39|      43|      35|      76|       4
---------------------------------------------------------------------------
   35-   76 (63.16/45.53)	PqdMLQHATQMHHPVNSyYPENNDLTGGLPINLDS....LRDGPPG
   79-  121 (61.64/34.14)	P..FYPYSTLIRYAIKG.APNQKLLLEDIYYAIESrfpyFRSAPPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09441 with Med18 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RGKGSYWTVNDNVDPRTGVHRVRKKKPKGGAGKQPVAIEEDIDYHPDAGQQPTFDPNVPFVPQPPMGPADAGPSRQAPYPPPYPTYAGPFAD
146
237










Molecular Recognition Features






MoRF SequenceStartStop




NANANA