<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09438

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAKGEKELPSLPIYESRPPDWLPQTHISADLGYVGFFPPRPDQHEELLTEANVKNGLILGLSVPAETYSAQDAVRNRLVQENALGELEDLMNQIFARRIENLPSIPVTLNDAKRQAWFDDLANPDVPLHRMGKNVPHGAKGHDLLDLLHSNNVAIPRAVWFLRVFGGNESAGLRNKPTYNPTQYSTDWANLVTSYIKKQLTDIALPSAPRPALNVKQTFKGVLSEAESRDRWISRFTYCLNLLRTFYSEGLVDNLTFLSWLVQQMGSCTLAQVGFVARLADEYLDGMLVSRALTRPFVEACLNKLSEVSDRSLNKITAMLNESQMLATSAKDYLVNVEIVLRSLISRAFLALPDAFVSPRMWIQHSTFLEQLLMDALPGDSSGSTGQQNVNALHHTFLERLSDVKRRNEAMLFRHLPPRVLGVLSSALSDIKLLNSLSGKTDMESVTFFEDASELSPSFARKLDTLLTWSVTPLQYGDHRPYAAACIILLWRNRAEDRAIRRDAPSPDEHIQDLLFDWLDASDVAAEPENIAAVALLFGQLVKRALFSYTKYIQRLIARGEAGIAFSEASDDIVLHLYDHISQSIYLGHGLPSQKLPTSCTPLISQRKVTLYGVRARDIPEDSNEREIRKEIRALLPELFGGNAQPIEAMSTTFWTACSTLLSAPRFEQVKTVKQWLLPILKKHISSQAQDSFSADNVTLKVYTLTSILLARIKCYGSILELALCMLEHSYTNELLIAVIETLRQHMEVWACMNIMKTVAAALFAAHQFWRARGVQSRALLTLLVEIDNDRYLEPGSREHIQTDISTYTHALSPINDNPDTVPQVLPEILLLATDPNPEAPSLLANALWYKYLTASDWAWKVWDNTIASLRQIPVIFPDVDGRRACALRYGTFLTHVDQHLPNGFDDQVLTWFLGAGKNEVAALNAEAWDVVTVVLLYLAVHGALTTTTILQGLVYPTWQAGASASSAEYGQSLATILSAVNNIFEHLLLKDECGREMPPMNLFQAQGLQTRRRDVFREPHFSSLVANFPALVLIEQNKYLSLGSREASTVLRQTICHVSVFRQGIYRNLDTVRLAFEKLLESQTIADDLHEPLVNALRLMLNDSGQGRTLLLHCQSFDPDFYLIDGPVDATEWRAVSSLLSPWKLAATAIEIRLTLKQLGEGLCRDATRSSSCASLDKLTTAVFYHCKTPEEADFVAEMMTDVSRAVAGKFVNAGLHRIIEIFHEASNPSDPKCLMQLVANAGEVLRLLSNIVEPFRQDNPMPQLEATIQDGFMTAFCTKLEEITEVLTAHVDNNSDESARSQTSHTAVFLARLLQFNLGFPGAWTSEAKAQSERLCTTITRLALYHGAGSTLDLLAFPLLLDTLFYALDEVPVDLKATSIDLFHNYPEFDLSDLPADMPPEYRMQLRSLLPYVSLNTAVCNLVYASRDSSGAITNSVPVQNRPWEWTENLGDNTSAEAKGDDRAGDDRLPVKNSASLPLELFGARMTGDQVLPSQASADDPMLEENLRTFQDDLFAGSIFQRDWRETRIGLNDGGAARSKGEHDEETLPVFAGPGSSERRSTSRRVSPASSVRSAASAHHSALGSVPSLRQSPVHLLSRLSVSTAGEPIDVDSFEMPTSSSRSATKRKATSSLPDDEIQVIEGPVASSRSSKKTKAKPAAKSRAKKR
Length1669
PositionKinase
OrganismGrifola frondosa (Maitake) (Polyporus frondosus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Grifolaceae> Grifola.
Aromaticity0.08
Grand average of hydropathy-0.158
Instability index50.24
Isoelectric point5.63
Molecular weight185424.74
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09438
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     646.41|     214|     238|    1143|    1376|       1
---------------------------------------------------------------------------
 1148- 1376 (331.40/229.86)	ATAIEI.....RLTLKQLGEGL...CRDATRS.SSCASLDKLTTAVFYHCKTPEEAdfVAEMMTDVSRAVAGKfVNAGLHRIIEIFHEaSNPSDPKCLMQLVANAG.EVL..RLLSNIVEPFRQDNPMPQLEA...TIQDGFmtaFCTKLEEiTEVLTAHVDNNSDESARSQTSHTAVFLARllqfnlgFPGAWTSEAKAQSERL..CTTITRLA.LYHGA.GSTLDLLAFPL.LLDTLFYALDEVPVD
 1379- 1612 (315.02/175.52)	ATSIDLfhnypEFDLSDLPADMppeYRMQLRSlLPYVSLNTAVCNLVYASRDSSGA..ITNSVPVQNRPWEWT.ENLGDNTSAEAKGD.DRAGDDRLPVKNSASLPlELFgaRMTGDQVLPSQASADDPMLEEnlrTFQDDL...FAGSIFQ.RDWRETRIGLNDGGAARSKGEHDEETLPV.......FAGPGSSERRSTSRRVspASSVRSAAsAHHSAlGSVPSLRQSPVhLLSRLSVSTAGEPID
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     440.17|     151|     238|     630|     799|       2
---------------------------------------------------------------------------
  630-  713 (107.81/61.79)	...................................................................................................................KEIRALL..........................................PE..LFGGNAQPIEAMSTTFWTACSTLLSAPRFEQVKTVKQWLLPILKKHI...SSQAQDSFSADNVTLKVY...TLTSILLARI
  716-  872 (150.12/128.01)	YGSILELALCMLEHSYTNELLIAvietlrqhmevwACMNIMKTVaaALFAAHQF.wRARGV.......qsRALLTLLVEIDNDRYLEPGSRE...hiqtdistythalspindnpDTVPQVL..........................................PEilLLATDPNP.EAPS.........LLANALWYKYLTASDWAWKVWDNTI...ASLRQ..........................
  873-  955 (84.79/40.18)	.....................................................................................................................IPVIF..........................................PD..VDGRRACALR..YGTFLTHVDQHLPNGFDDQVLT...WFLGAGKNEVaalNAEAWDVVTVVLLYLAVHgalTTTTILQGLV
  970- 1142 (97.45/55.74)	YGQSLATILSAVNNIFEHLLLKD............ECGREMPPM..NLFQAQGLqtRRRDVfrephfsslVANFPALVLIEQNKYLSLGSREastvlrqtichvsvfrqgiyrnlDTVRLAFekllesqtiaddlheplvnalrlmlndsgqgrtlllhcqsfdPD..FYLIDG.PVDA...TEWRAVSSLLS........................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.38|      24|     236|      21|      44|       3
---------------------------------------------------------------------------
   21-   44 (48.92/29.05)	WLPQTHISADLGYVGFFPPRPDQH
  260-  283 (44.46/25.76)	WLVQQMGSCTLAQVGFVARLADEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.02|      48|     367|      95|     208|       4
---------------------------------------------------------------------------
  130-  179 (80.48/144.31)	RMGKNVPHGAKGhdLLDLLHSNNVAIPRAVWFLRVFGGNESAGLRNKPTY
  210-  257 (83.55/27.54)	RPALNVKQTFKG..VLSEAESRDRWISRFTYCLNLLRTFYSEGLVDNLTF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09438 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPIDVDSFEMPTSSSRSATKRKATSSLPDDEIQVIEGPVASSRSSKKTKAKPAAKSRAKKR
2) GLNDGGAARSKGEHDEETLPVFAGPGSSERRSTSRRVSPASSVRSAASAHHSALGSVPSLR
1609
1532
1669
1592










Molecular Recognition Features






MoRF SequenceStartStop




1) SLPDDEIQVIEGPVASSRSSKKTKAKPAAKSRAKKR
1634
1669