<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09431

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTSEKMPLMLDNPMPVDLNDVDDLFGDAVGVGLSLSGRVQSKQLQQRMDDIRIRGCCQAVAWSRTGSIANITPDGQNVELRYLRRSPDDGSWDLSDPTTCPFAKGTPTIPIVHLIWAGTSTPDLAVIDAAGRVTIVSFSISLNHPFVQRKWDADPIDDVHTIVGAYWLTVAPSNQQSYNIMYGPANKQHNGYTYESSFVHHSGPSHPNPAKSALLTITTHGVLRMIWSQNNSRVEETTIELESISASDELITHATFTSEKKHLLLALATTSKQLRLVKIEIQWGQASQADKVPGRPAGNLSPSLVEKHLATTNWLQGGPGDSSIDASMIELSHLEVLPSLLDNTGKNPTSPMVVTVKSRTSSEGSYQAAQSVLDRWEVVEQRQNLSSAWEQLGSRRNSISSELPPVTQLRKVAPITSNKVVVAFHTLTFGKILVLAFADGTVEYRDRLTFDEIYTTQEFNKIMNLRQVGWTFTDEVPCQQIAFSPTYCSMVQMGEDGKIKWTKLHYPNGDIGNTMQDANYAGSIAALSVTAAPAMFHQNNYDDILAIVRPYTTKKRFVQDWVTELIRILKIQIDYSEDTHHDSLVRNGSLQYCLSIMNALGFRGDLSPRSFLGKFSMLFLNVRNVVVLITIASNTPVTVREKLSPLDEPEVMATLVGCAKWALDLIAWLMDSLFELMNDSHFQSLLTRERFSEVASYLQEKNNVALHFLMSSSSRGFLSAVCRRLAHLEGLSGRAIEFYRRQSAVVEGASGRAAPQLQQAYQAMQQVTSSALVKVSEVETLLTELSKEIRQTYQIFLPSFVKGQANPPQGKQIDMAVKSTRSQIELSMLLSGSPPSAFIQIIKKFFATDLPLFRKSVDPGRLFFANYDLLEVQDDEHSLAAKKARGTLYVDVFKRMQIRPSPNKQWRRCSRCTAVMEDIFGSRPGFTFVLAQQRKCSCGGQWTLLPKGNVA
Length951
PositionTail
OrganismGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.08
Grand average of hydropathy-0.202
Instability index45.64
Isoelectric point7.31
Molecular weight105827.48
Publications
PubMed=17823352
PubMed=20237561
PubMed=26198851

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09431
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.12|      52|     104|     561|     612|       1
---------------------------------------------------------------------------
  561-  612 (91.51/56.12)	WVTELIR.ILKIQIDYSEDTHHDSLVRNGSLQYCLSIMN.....ALGFRGDLSPRSFL
  661-  718 (78.60/47.25)	WALDLIAwLMDSLFELMNDSHFQSLLTRERFSEVASYLQeknnvALHFLMSSSSRGFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.49|      62|     325|       4|      70|       2
---------------------------------------------------------------------------
    4-   70 (93.91/79.68)	EKMPLMLDNpmpVDLNDVDDLFgDAVGVGLSLSGRVQSKQ.LQQRMDDIRIRGCCQAvAWSRTGSIAN
  335-  397 (101.58/66.80)	EVLPSLLDN...TGKNPTSPMV.VTVKSRTSSEGSYQAAQsVLDRWEVVEQRQNLSS.AWEQLGSRRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.45|      17|      32|      72|      99|       3
---------------------------------------------------------------------------
   72-   88 (31.74/39.88)	TPDGQNVELRYLRRS.PD
  106-  123 (28.71/ 9.39)	TPTIPIVHLIWAGTStPD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09431 with Med16 domain of Kingdom Fungi
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