<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09429

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGERPTVNGAHTPNGTHQSTTDSSSSANPLKPGSLPQNLLPPPPPPTIDRQENGDAWSNRWDDDGAGHSVANIENHAPPEILSLISQDSYLPMAALISRASQTCWNGLSDLVEQLASLSVPDLPPEQAKLMPNGFTNNQSKANLDKKDKIFKFANEQKADFIKLLVLLQWSKNVDEVSKTISINYWLMLRRQAYWGAIASMASLKQESSNFQIPNPDLKTAAEVLSTGRVGNFPRLGYIARPDLSPKQILRVLKSLDQALSVRLALSDNLPPQLRNFRIHDGRATFIVPNEFELDLSTLDESFDSPLRMVDFRLSFQPCPHLPDRLQSEIELLANSNIDQGGLGRCYEFLHELALSYKLAEFHTQAIELSRHQWVGNLRVELIRRNLIVQYWPERHGGKSWVEIGITSGRGRQRPADLEPHSSLEIKCTWHGKRAERLHLHVDESVLCFEDILRQVVAQHSTQILDTIYDKLVSTPLFADAELSLEQSLSHDDPEVCSLVMQLSRSSTLQLKVDPVTGLIMVSPVTERAERLQFEVNRVQSVADEVVSKLLNFRCSVRESTVLAGISGTRWEALRSFKFTQAEIKSLFGRPVVRINMFRQSQWGLEYSLAVTHSQDSDHWWLLQQVPLGAASSQARYKVLRSQRIGAKEELSSAYFDRLADYSMGLICIQRNADFLTEKNEKFGLRPFPAFDRFYELPELSFDLDLGRPLPSGQSLAAGAADSTLTIPKTSDIPAKDASLQRNIQVRFGGVDRSDLWVMTVAQYQTQASSAVLGHLDKSVLDAGVKINPEDRMVTIRMATPMAEAAIPQIIARVLDLEKVVSTVEQIHCLLGLKLKRISDSTISMVYHQEAPTELGLNITLTSGSPAPRLEFFPHQLNPHQILSQVYAKTFAANRAPFATTMRNLLTSWTATLPLLTILHKLQQRHEISSKTDQQQPSAEPEDYLRVHVLARTETQFALQYFMPAGQAANDTKNDSPPQLLARFEILSEANHSGKTGWLVRPALEEFQSYSRPSYSSPDLADKVKQEIFSQRTEGQSKWFQLDRGAWCTVDRPEPLLNALHDVVWNWAKQAKMSGANAGSKQDSNKGKGPPGNSNANNPSVTNGTNNRGPGPAKGAPGRQQAASNAMPNGANMKVQRPPLNAPGGRPAPGNAKTNARNPQGKDVITLD
Length1169
PositionTail
OrganismCladophialophora carrionii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.417
Instability index48.30
Isoelectric point7.00
Molecular weight130018.67
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09429
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.96|      23|      23|    1104|    1126|       2
---------------------------------------------------------------------------
 1104- 1126 (42.70/24.01)	NGTNNRGPGPAKGAPGRQQAASN
 1130- 1152 (44.26/25.18)	NGANMKVQRPPLNAPGGRPAPGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.23|      24|      92|     420|     444|       3
---------------------------------------------------------------------------
  420-  444 (41.56/34.22)	EPHSSLeIKCTWHGKRAERLHLHVD
  515-  538 (41.67/29.02)	DPVTGL.IMVSPVTERAERLQFEVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     237.80|      70|     226|     336|     413|       4
---------------------------------------------------------------------------
  170-  203 (39.19/18.21)	...................................................QWSKN..VDEVSKTISINYWLMLRRQAY.......W...GAIASMA.
  336-  413 (116.58/94.54)	NSNIDQGGLGRCYEFLHelalSYKLaefhTQA............IELSRH.QWVGNLRVELIRRNLIVQYWPERHGGKS.......WVEIGITSGRGR
  560-  637 (82.04/51.39)	ESTVLAGISGTRWEALR....SFKF....TQAeikslfgrpvvrINMFRQsQW..GLEYSL..........AVTHSQDSdhwwllqQVPLGAASSQAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     341.26|     110|     896|      19|     147|       5
---------------------------------------------------------------------------
   19-  147 (169.72/118.53)	QSTTDSSSSANPLKPGSLPQNLLPPpppPTIDRQENGDAWSNRWdddGAGHSVANIENHAPPEILS...LISQDSYlpmaalisrASQTCWNGLSDLvEQL.....ASLSVPDLPPeqaKLMPNGF...TNNQSK.ANLDK
  924- 1045 (171.54/85.11)	QQRHEISSKTDQQQPSAEPEDYLRV...HVLARTETQFALQYFM...PAGQAANDTKNDSPPQLLArfeILSEANH.........SGKTGWLVRPAL.EEFqsysrPSYSSPDLAD...KVKQEIFsqrTEGQSKwFQLDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     181.29|      41|     226|     470|     510|       6
---------------------------------------------------------------------------
  258-  287 (24.18/ 8.45)	............DQALSVRLALSDNLPP......QLrnfrihDGRATF
  300-  324 (30.73/12.70)	LDESFDSPLrMVDFRLSF.QPCPH.LP.....................
  470-  510 (68.11/36.96)	YDKLVSTPL.FADAELSLEQSLSHDDPEVCSLVMQL......SRSSTL
  692-  726 (58.28/30.58)	FDRFYELP......ELSFDLDLGRPLPSGQSLAAG.......AADSTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.73|      11|      23|     832|     842|       7
---------------------------------------------------------------------------
  832-  842 (18.19/ 9.94)	LGLKLKRISDS
  856-  866 (18.54/10.26)	LGLNITLTSGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09429 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNGERPTVNGAHTPNGTHQSTTDSSSSANPLKPGSLPQNLLPPPPPPTIDRQENGDAWSNRWDDDGAGHSVANIENHAP
2) WAKQAKMSGANAGSKQDSNKGKGPPGNSNANNPSVTNGTNNRGPGPAKGAPGRQQAASNAMPNGANMKVQRPPLNAPGGRPAPGNAKTNARNPQGKDVITLD
1
1068
79
1169










Molecular Recognition Features






MoRF SequenceStartStop




1) ANMKVQR
1132
1138