<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09425

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMAAPRSGAQARNAETTNAPSLGKPDSDQDHDYRPVSPYSYRVGAASGTRAVARAGIKGKRFDNAPDLRVHRHRKTKYSYRIGIRLAREKLLTFPQYNGRVKDSVRQWGGSFVTLKVPPWQLRAIDAIGAAPRNTIVPTAVVSVLGRPVSSLPKVSTARSPFTTTTSAPSRLSVTGASSFSDADLGQPNTPFTTYPSPEAEADPRCIEAKTAAAQQDLLLAQTTGSFSARDTRGRYSAPTAATAATAATFQIGTTFDDLPVAERLIRNNTMAPVKDTSSVHNTIKGIIQHLTDIQLQTHGYIPQTQDLLVDKLTDLTTSLAELKRLTSAQESPNNYIHQVAIAPEIVDYVDDGRNPDIFTRDFVEIVQRGNAVVHGKQRAFRDFTEVYARKLKEGIPGVSAQVDRVLKNAGFEEQDASRSSTNGVHDAERNVDP
Length433
PositionMiddle
OrganismCladophialophora carrionii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.06
Grand average of hydropathy-0.494
Instability index32.79
Isoelectric point9.49
Molecular weight47106.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364146

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
kinase activity	GO:0016301	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09425
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.68|      33|      34|     282|     314|       1
---------------------------------------------------------------------------
  282-  314 (56.21/42.39)	TIKGIIQHLTDIQLQTHGYIPQT..QDLLVDKLTD
  317-  351 (50.48/37.32)	TSLAELKRLTSAQESPNNYIHQVaiAPEIVDYVDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     144.27|      37|      37|       7|      43|       2
---------------------------------------------------------------------------
    7-   38 (53.22/28.07)	..................................................GAQARN..AETTNAP...SLGKP.DSDQD...HDY.RPVSPY
   39-   77 (37.74/17.85)	SYRVG..........................................aasGTRA......VARAG...IKGKRfDNAPDlrvHRH.RK.TKY
   78-  161 (31.43/13.68)	SYRIGirlareklltfpqyngrvkdsvrqwggsfvtlkvppwqlraidaiGAAPRNtiVPTAVVS...VLGRP.VSSLP...KVS.TARSPF
  162-  191 (21.89/ 7.37)	..........................................................TTTTSAPsrlSVTGA.SSFSD...ADLgQPNTPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.50|      31|      32|     208|     238|       3
---------------------------------------------------------------------------
  208-  238 (51.10/38.44)	AKTAAAQQDLLLAQTTGSF..SARDTRGRYSAP
  240-  272 (46.40/34.17)	AATAATAATFQIGTTFDDLpvAERLIRNNTMAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.73|      24|      28|     377|     403|       4
---------------------------------------------------------------------------
  356-  374 (22.44/10.57)	........DIFT.RDFVEIVQRGNAVVH
  377-  403 (32.69/29.16)	QRAFRdftEVYA.RKLKEGIPGVSAQVD
  408-  432 (33.60/20.69)	NAGFE...EQDAsRSSTNGVHDAERNVD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09425 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAAPRSGAQARNAETTNAPSLGKPDSDQDHDYRPVSPY
1
38










Molecular Recognition Features






MoRF SequenceStartStop




1) DQDHDYRPVSPYSYRVGAA
2) KYSYRIGIR
27
76
45
84