<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09416

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNATLDFPAANPPTPDPSAFVATPENILARLRTTERQFRENSILAALDVEARQLFTFYKKVDITAPKDQKALLMKFGFVLRSNSCTIAYKTAARLPDLMKPEQARLYRLFITAIVSSVKLIPVGNTALQPIGSNLYLVETAPPATEHDNFAERRPWVLYRIDLQVVLNGHIVLTIAKDTILSFLPLHHCLAGTDGEARESDFMAVYLAPVGCIARVSRSKLASQRDMDGDLAEKHHGEARISDARREIWRDLLPSWLREHMDIAIKASDVPWVEAEVPVEELGHSSDGNQSDVANEEVALGEPITWRSIFWPANLCFVLEGASSAQTGTTEIDDDPMKFVGDWILGIGSAPSKGETGRQVVKEDEEDEPLFADDGTFDDPEHFQPFGPPTFPASQTIYPTPPDVGITHPTPGISSVDGVVMTPANLPGGSSELAQQRDEEMPDFDDVPPTTGMSGYYDEDLFEEMPDDNFGQEANGDEPNWDFFDGPGAQPKQSRSASHSRKEGSTSRGDPKQEQVDPSDANTGGRQLSDSLNPSKNEIFTVGDSPHIPTGAQPQMPSSQTAVKDTVISLDENKRSQSPPKPAPPLWRSEQDKSTTSTTNTRRRSSIYDNPKALHSVPIHDSRYDAEGDYWFNPLPVVSRSRTRPKSSSMFERPSSPSESDSSMTSSSQSPKANVSGDVLPPLFRQWTEYDPGSQDTNSHQKELDKTTIQREVQQLLGLLKPGLVEPPTVADFELGDRDARQTPLITSQKSQHVAQVLVDQMSQTSLLAHGEYQGDMRNFSDECIEMNVDLSGINTSAGPSNLFQLVNLNTEHSSARLQGRVTKIRPSQICLRRIERPLTANISIMNFWDTLDLQPANGQKHVTAFCIHPRPANIRDGSLNLLQRLSDSYTTCDLGTHTIGHLPGVTDDGLISWNPEGPGERSLIQCTTMVGSALAAATTTITGTIVVYMVSRSDSPTAYLEMCIAFYNLFEAFSKARTNSLCVSDLQLQIIPQSFIANPETLVIHPQTAYLKLAVEVYNRLPPQDPTGHPSACGSAVVLSRSENTVRLQLSPTYVSPLEKNGPCLHLAYSTSLDKKWLVAVWTDELGHIALSMSYCTHMRVSGRKRARHEILKEMWEVSHDLMSKVRGPWRLAVVRHGYHEPAEILEWHQVVDQSPAPQKQCLFLLLSIQLQPELVVFPPPAHGKAPPAGAHNQYGTPVSTPQASMTSPDQAVPATPTPGGSSLMNASTPPDPGFDPSAESDLTIVDPSEDSWGIILPYGINQSKSMTELRPSQVTGFLMKRRGPRSEDGFNMIEISLVTSINPTSNKPNEIMPDELLDDVVRQYRGLVTLGASRGCVEPNRECLPWHVATAIRGARILELAM
Length1364
PositionKinase
OrganismCladophialophora carrionii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Cladophialophora.
Aromaticity0.07
Grand average of hydropathy-0.428
Instability index55.08
Isoelectric point5.12
Molecular weight150081.88
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09416
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.38|      22|      28|     545|     566|       1
---------------------------------------------------------------------------
  507-  528 (24.11/ 8.97)	SRGDPK..QEQVdPSdANTGGRQL
  545-  566 (40.71/20.82)	SPHIPTGAQPQM.PS.SQTAVKDT
  576-  595 (36.56/17.86)	SQSPPKPAPPLW.RS.EQD..KST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.40|      21|      21|     440|     460|       2
---------------------------------------------------------------------------
  402-  419 (25.16/ 9.24)	..PDVGITHPTPGISS.VDGV
  440-  460 (43.52/21.58)	EMPDFDDVPPTTGMSGYYDED
  464-  478 (21.72/ 6.94)	EMPD.DNF....GQEANGDE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.28|      15|      41|     597|     611|       3
---------------------------------------------------------------------------
  597-  611 (27.52/17.39)	STTNTR.RRSSIYDNP
  639-  654 (22.76/13.06)	SRSRTRpKSSSMFERP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.25|      39|      43|     677|     717|       4
---------------------------------------------------------------------------
  677-  717 (64.71/46.66)	GDVLPPLFRQWT..EYDPGsqDTNSHQKELDKTTIQREVQQLL
  718-  758 (61.54/38.04)	GLLKPGLVEPPTvaDFELG..DRDARQTPLITSQKSQHVAQVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.68|      78|     791|     331|     431|       6
---------------------------------------------------------------------------
  331-  431 (127.54/85.79)	EIDDDPM.KFVGDWILGI...G.SAPSKGETGRQVVkeDEEDEP....LFADDGTFDDPEhFQPFGPPTF....PA.SQTIYPTPpdvgithptpgissvdgvVmtPAN.LPGGSS
 1118- 1224 (107.14/58.35)	EVSHDLMsKVRGPWRLAVvrhGyHEPAEILEWHQVV..DQSPAPqkqcLFLLLSIQLQPE.LVVFPPPAHgkapPAgAHNQYGTP....vstpqasmtspdqaV..PATpTPGGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.90|      14|      22|     214|     227|       7
---------------------------------------------------------------------------
  214-  227 (23.13/14.14)	ARVSRSKLASQRDM
  239-  252 (24.77/15.66)	ARISDARREIWRDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     292.25|      94|    1218|       9|     112|       8
---------------------------------------------------------------------------
    9-  112 (142.97/119.65)	AANPPTP..DPSAfvatpENILARLRTTERQFrenSILAALDVEARQLFTFYKKVDIT.......APKDQKALLM.KFGFVLRSNSCtiAYKTAARLPDLMKPEQARLYRLFIT
 1228- 1331 (149.27/99.25)	ASTPPDPgfDPSA.....ESDLTIVDPSEDSW...GIILPYGINQSKSMTELRPSQVTgflmkrrGPRSEDGFNMiEISLVTSINPT..SNKPNEIMPDELLDDVVRQYRGLVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.64|      45|     229|     800|     849|       9
---------------------------------------------------------------------------
  800-  849 (73.33/50.07)	PSNLFQLVNLNTEHSSARLQGRVTKIRP...SQICLRrierpLTANISIMNFW
 1031- 1078 (75.31/41.31)	PSACGSAVVLSRSENTVRLQLSPTYVSPlekNGPCLH.....LAYSTSLDKKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.36|      12|      48|     958|     969|      10
---------------------------------------------------------------------------
  958-  969 (24.20/14.87)	TAYLEMCIAFYN
 1009- 1020 (21.15/12.25)	TAYLKLAVEVYN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09416 with Med13 domain of Kingdom Fungi
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