<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09407

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNGSAGKQTAAFDNIRLSLDRATLDAALGKRKVQAIDVNGQLLYDEEKITTDRLTEQLERVWNEYPNGLLDINEERLEKLSSDEHAVKKEESKEDQETERDPSKMMSRGEMDELRTEVHEQLNAARNELWFVLELAKTLSVSSSFTHQPPPPPSQQPDAGPKKGKQRPAKANEADVNTASGLSTSVPQEPPVLPPGTFSITPSTQPTKPPHTQVHELELILKSKQQALDECSALIDSAVSELQMMASAGDRFWRDIKSLKDGQNGRDQWAILPKPDFGRTMVEGEKSKDIIIPYSVDEAPRATRSRCLAAFDLDPTKEDDLTFGSRSHLRLRTTLKDVSGAVVGSSPVIVGNSSGVRAQMEAAQMEAFDEDLFSVLRYEASQISKSELEPKSVSFPAAEYTLSFELYDTRTRSQIPTSPLCDLIVSSAQSNLLNLHRHRKSRLVSPMSSSTASPTLLKPIVHALRYRQLCNTINSTLSNFASIFETAGLEASSTCQMIAGQSSSEAISEFLVGRSDTSKLSGTYRLDIPGCRGVKIDAHAPFRTSVTLTNATFDLSNPEELSHILSEEFATQILTLLRSELRNRISDASIRSRLFLDELEGMIHLSQIGLIRQPELAILNEMADD
Length625
PositionHead
OrganismKwoniella mangroviensis CBS 10435
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.05
Grand average of hydropathy-0.469
Instability index47.63
Isoelectric point5.23
Molecular weight69093.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09407
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.66|      24|      24|     426|     449|       1
---------------------------------------------------------------------------
  398-  422 (18.75/ 7.59)	..AEYTLsFE..LYDTRtRSQIpTSPLCD
  426-  449 (39.77/23.49)	SSAQSNL.LN..LHRHR.KSRL.VSPMSS
  450-  475 (34.14/19.23)	STASPTL.LKpiVHALR.YRQL.CNTINS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     224.05|      55|      57|     102|     156|       2
---------------------------------------------------------------------------
   52-   97 (51.17/23.98)	...........DRLTEQLERVWNEYPNGLLDINEerLEK.LSSDEHAVKKEESKEDQE
  102-  156 (93.95/49.34)	PSKMMSR.GEMDELRTEVHEQLNAARNELWFVLE..LAKTLSVSSSFTHQPPPPPSQQ
  161-  213 (78.93/40.43)	PKKGKQRpAKANEADVNTASGLSTSVPQEPPVLP...PGTFSITPS..TQPTKPPHTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.95|      13|      24|     252|     267|       4
---------------------------------------------------------------------------
  252-  267 (19.99/20.88)	FWRdikSLKDGQNGRD
  277-  289 (22.95/14.05)	FGR...TMVEGEKSKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09407 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) INEERLEKLSSDEHAVKKEESKEDQETERDPSKMMSRGEMDELRTEVHE
2) VSSSFTHQPPPPPSQQPDAGPKKGKQRPAKANEADVNTASGLSTSVPQEPPVLPPGTFSITPSTQPTKPPHTQVHELELI
72
141
120
220










Molecular Recognition Features






MoRF SequenceStartStop




NANANA