<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09396

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASSSAGPAPSSSTGFGISGISDLPNHASSSTQPFTKPRNPQLSNEPWFAYPTPTAEQIEEELPPYFEGENVPLGPLLDRLVRKGYGDLRYLLAEILPPLSAKQKPKHIINYATTTRQALLKYLAVLRWKSAVDVPSSYPYASSSTNLPSHINGQNGMINNFPTPHSNGDDTSPASISSTNKGKGKAQATGVDNEDVLIKGKVTDSRRLAQFMEHQNKQHDDAVAHLQHVTKLVESLRERNPDLLTAIALVTTGTYQRLPTSITESFKPQPPLTNSAILSLLRKLNRQIKYRLRCIDYIPPDLVVEGIRDGQVYFIGGGEHGWRIRMSIVGFGVESKWWLTGVEWLWRHRERGVNDPGGESRKKFTGEERQSILDLANLEILPPRVDQAEDSQADTTKKRSNHVEKEEAKDKVMDAPLVRIYNFIQHLSLSYQLEILFTQAMALSQGKWRNQLRVEIDRDTKTLKVKYWIRPRPAVIPQQQQAAVGKRPTLVSSGGSSRTPLVGGVISVSLSEANIPQNESAAFMGLVASGQVTSDERVLNLRLGVKWEVGELGIGGGLKVGDVMDGGSLQIDPASLDMENLIMTSARAHAAHLTRVQASALISSPKFILSLLNQPTLQESEDPTSSCPLTLRIPIPSRQNVSSLIIGVSAYNGHIEIEDDGSIGNEVRAERVELAMKSINDGKTRLVDDIGRLTVAVVMENLEDQMRQLGWKPIRRLALRSQDLAKVQLHPATTVLTPILSAPTYYFVAKVTQAGLAFELLKVIKVPSETGMGVGMKSAVGDRIPLDLERLKSREKGKEVDGTLNGTLFEIGNKDLKNLYIYSNALVAQTIIENQLKERNIPFTAQYPPTTQSGPNVTRSSSALAGMIPTICVDVRDLLRNGTRGAAVDVAMPKVGMQIENWWTGGKCEVSTIVRLRQQSSMTQTSTNGLSDINTPQAHSEDISFDPTSSIVKFRAKEIERCVPAFLEQWERLSKVIVVAGEVNRLNKYAEFSDIKMLSFDLRTATLSYSSDYEASITYLPVDDSYQVTLSRNNVPIPSKPSTENTTNIDNPHERLSSLLSARLTELAATPLEGIPKGAVGREFFGLLKNTLPFFEQVEKLKERGWDLIVLDIRTYRIMKDYKGRRYALDIILIPALSHYLIQSSLKPKGPDKKLDFEIIGQITELPLNKIIPKIYNNLKSSSSSSSSSYHLKNLINSNDKEIINIPPLMKLDKDQSLICKVNLIQNVLIEFMDKVDEYIGFKKDQ
Length1247
PositionTail
OrganismKwoniella pini CBS 10737
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.06
Grand average of hydropathy-0.329
Instability index39.60
Isoelectric point8.69
Molecular weight138269.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09396
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.02|      15|     277|      69|      99|       1
---------------------------------------------------------------------------
   83-   99 (25.26/49.08)	RKGYGDLRYLlaEILPP
  370-  384 (27.76/ 8.59)	RQSILDLANL..EILPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.46|      23|     277|     789|     811|       2
---------------------------------------------------------------------------
  789-  811 (39.39/23.04)	LERLKSREKGKEVDGTLNGTL..FE
 1073- 1097 (36.07/20.50)	LEGIPKGAVGREFFGLLKNTLpfFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     347.04|     118|     907|      18|     166|       4
---------------------------------------------------------------------------
   18-  166 (178.83/159.45)	ISGISDLPNHAS...SSTQPFTKPRNPQLSNEPWFAYPTPT.....AEQIEEELPPYFEGEN......VPLGPlLDRLVrkgygdlryllaeilppLSAKQKPKhIINYaTTTRQALLKYLavlrwksavDVPSSYPYASSSTN..LPSHINGQNgmINNFPTPH
  911- 1054 (168.21/114.27)	VSTIVRLRQQSSmtqTSTNGLSDINTPQAHSEDISFDPTSSivkfrAKEIERCVPAFLEQWErlskviVVAGE.VNRLN.......kyaefsdikmLSFDLRTA.TLSY.SSDYEASITYL.........PVDDSYQVTLSRNNvpIPSKPSTEN..TTNIDNPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.40|      60|     323|     506|     568|       6
---------------------------------------------------------------------------
  506-  568 (94.28/77.89)	VISVSLSEANIPqnESAAFMGLVASG.QVTS..............DERVLnLRLGVKWEVGELGIGG.GLKVGDVMDGG
  832-  907 (90.12/62.85)	IIENQLKERNIP..FTAQYPPTTQSGpNVTRsssalagmipticvDVRDL.LRNGTRGAAVDVAMPKvGMQIENWWTGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.32|      12|     907|     234|     245|       8
---------------------------------------------------------------------------
  234-  245 (21.60/14.53)	VESLRERNPDLL
 1099- 1110 (22.72/15.72)	VEKLKERGWDLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09396 with Med14 domain of Kingdom Fungi
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