<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09389

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMIDFLGGDPPRPTTTVPDQWIIDLPTTDTHICIYRYRQSSRINQAGPSTSSSSFRDILVDPFERAWRTVNDASNEDYTIKHALDEPCGIISNEDGEKAFWYFSSNNDVESPEFEGLEVFTPSLQPLSITQLVTCSKHGHDTSCLGRKLLETDTPCNISLDLSGGVARHLDLLASALVEKMAWKRGHRLSTQLTLTSSYASLNPALRPISPQKFLLTVRPSSTPSSSSAHTPSPLILAPLGLPALQIGPSFLTGAQESHLISTFDTTFSHTWKDGRSERRAKSHILGGTYSDWSIYWVPIDDKTSSSKGKMTPRQLVKSWQSSQGVLTIWPTHLSQSYFTFTPPKNRDANVKPHLPDIESSDLLGISTGLFDFLSTYKEPDPPVDQEEDEEDINMDAESTVITVEADSDQILHQSTGLNDLPDGIEGGDSDLDDLFSAHSDSPNVTIIPDQDQPIILMGDTDTPIEVSSSDIVNSTSPKIPITNNNTGGPARLSRNGTGNVLENGQKEEMVTEDDFAFFDSPTDEIDAPLEDTNGFEERKQDILDVHQHISTDVHQHISTDVTMEVDSHHQIDQIEILPVQEAKISEQHSSLDSQPVATTENQNIPAATHEDIDGFANRSGIQQDMLLLPVATLPSPPVPPSPNLVPPPFPLPHIVPPASWVTKDLVPPSFSPLPLLPQLDSPFPYSLPTPAPTPSDLNWNLVERLQPPKSSNPSYAKDWKVDEELSELDDADTYTGPPTPMSDYSTDSEEEETNRKNDAQTTSSTPPEGFEYVVEFGGIRCAGADWIHLIYDVQTLQSHAVDWNPSWDENLDKSLVPPHSPPEQVIMKNWHKGLDVSGLIKELVGNFVLRDTCSNRSQRSATMINAERFWQSSSIKEGMSLSDLNSSMKSRSLSQPQLSAGYHHYSINLNISSIQYWTELGLQPHGGYKDVRAKFLCVASDESAGAADWAVQIGKQISRIWKEMNLGHHNLTADRVITVKPSALLESVATTLNQSQANTALYIVLPINRIITSAIKDLFNYSVSPSCSTVIHILPSHSLSLTDCKQVALEVYNKISEPIRETNPRTVSDPYGLQQLESEHESERTTRQAFNLARTEIPTPEFSMSWPLQSYDVLNKNRFIHSTYTINEDIGVMIVFIIDDLGEMFDMNIWTDIDKIKWENRVEKLFRWIKVRADKWIIQWRLTLMRSGRMMENELNAWNQLLENSNSPITLLLVDQQEYNELKENENIPHPKGFSNIPISTLNDPTMSIINLNYLAQLTIFENKIPIDLLSSNEEIKVIYPLSTFLISQSLKGLEGYESKLYNILYNQFPLNYNKKKKEEIEFELGEEIYRLNCLIDLRWKIQGGFQGLLEIIIQGLEFISEPKENE
Length1367
PositionKinase
OrganismKwoniella pini CBS 10737
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.08
Grand average of hydropathy-0.445
Instability index54.51
Isoelectric point4.71
Molecular weight153187.54
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09389
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     205.43|      45|      45|     366|     410|       1
---------------------------------------------------------------------------
  333-  368 (32.76/15.30)	....LSqSYFTFTPPK..............NRDAN...........VKPHLPDIESSD..LlgiSTG
  369-  416 (73.22/44.98)	LFDFLS.TYKEPDPPVDQ....EEDEEDI.NMDAE...........STVITVEADSDQ..IlhqSTG
  417-  455 (39.84/20.49)	LNDL.......PDGIEGG....DSDLDDLfSAHSD...........SPNVTIIPDQDQpiI......
  459-  485 (23.44/ 8.46)	..........DTDTPI......EVSSSDI..VNST...........SPKIPITNNN...........
  517-  567 (36.18/17.80)	FFD..S.PTDEIDAPLEDtngfEERKQDI..LDVHqhistdvhqhiSTDVTMEVDS...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.52|      22|      45|     627|     651|       2
---------------------------------------------------------------------------
  627-  650 (43.06/21.25)	LLPVATLPSPPVPPSPNlvPPPFP
  675-  696 (39.46/15.29)	LLPQLDSPFPYSLPTPA..PTPSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     368.14|     117|     550|     176|     322|       3
---------------------------------------------------------------------------
  176-  320 (170.12/132.72)	LVEKMA............WKRGHRLStQLTLTSSYASlnPAlRPISpqKFLLTVRPSSTPSSSSAHTPSPliLAPLGLP.ALQIGPSFLTGAQESHLISTFDTTFSHTwkdgrserrakshilggtySDWSIYWVPIDDKtSSSKGKMTPRQLV.KSWQ
  701-  831 (198.02/94.41)	LVERLQppkssnpsyakdWKVDEELS.ELDDADTYTG..PP.TPMS..DYSTDSEEEETNRKNDAQTTSS..TPPEGFEyVVEFGGIRCAGADWIHLIYDVQTLQSHA...................VDWNPSWDENLDK.SLVPPHSPPEQVImKNWH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.26|      13|     621|     600|     617|       4
---------------------------------------------------------------------------
  600-  617 (17.41/19.74)	ENQNIPaatHEdiDGFAN
 1224- 1236 (27.85/13.86)	ENENIP...HP..KGFSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.17|      23|      49|     938|     960|       5
---------------------------------------------------------------------------
  938-  960 (38.45/25.33)	VASDESAGAADWAVQIGKQISRI
  988- 1010 (37.72/24.71)	VATTLNQSQANTALYIVLPINRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.77|      45|     765|      83|     131|       8
---------------------------------------------------------------------------
   83-  131 (68.77/64.37)	LDEPCGIISNE.....DGEKaFWYFSSNNdvESPEFEGLEVFTPSlQPLSITQL
  849-  898 (73.01/51.26)	LRDTCSNRSQRsatmiNAER.FWQSSSIK..EGMSLSDLNSSMKS.RSLSQPQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09389 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PQLDSPFPYSLPTPAPTPSDLNWNLVERLQP
2) SSNPSYAKDWKVDEELSELDDADTYTGPPTPMSDYSTDSEEEETNRKNDAQTTSSTPPEG
3) TYKEPDPPVDQEEDEEDINMDAESTVITVEADSDQILHQSTGLNDLPDGIEGGDSDLDDLFSAHSDSPNVTIIPDQDQPIILMGDTDTPIEVSSSDIVNSTSPKIPITNNNTGGPARLSRNGTGNVLENGQKEEMVTEDDFAFFDSPTDEIDAPLEDTNGFEERKQDILDVHQHISTDVHQHISTDVTMEVDSHHQIDQIEILPVQEAKISEQHSSLDSQPVATTENQNIPAATHEDIDGFANR
677
710
375
707
769
618










Molecular Recognition Features






MoRF SequenceStartStop




NANANA