<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09387

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAQETLSLSEVIGRAYARALPPKKFVQLLKSTVRSSPDAQDDLASAILPFLLPSPPSLILSYLTNLLSSSILTSRTIFIHILFYLSDHDLPPIPIINSIFNILASNLTGLEEPIPSFLSSPSSSNLETDKIPPEVGTSASAMNSPIINRENQMSTLSLILPLLKTISSNPSLSLNSSLVIYLSKVVSILSNFPLPSLDVGLEVGGLLPDLPEEINTHLRDHLSGLMTDLNNQGPTSQIQMQNGNVQSQVSQGVQDIQMNNLSNDRSQRKAPLKESIIFLIEWLKRSSKFDKSPRAGKELGHNWILLLKAGKYLTMDSSQFLSVLLEVGIQDLIRTDVEDLEAAQNWNILVGIMPALLSWWKEHAEEEFPFPVNITEILTDLFRNHSMAMQSYSENLSQRYTVLIQNAENEEEGSTFTSLEGWTLLSLQETLISKLVQSSLITSDEASTVAPGANSHTFSMGESLTNRLSSESHPHLPPLVHTIQYAYSASASFSEEVIQIIKSCPSIPPPESVFTYIASQPGLLGCLTSTISAKALLSLMEKQLLDIGVDENSRNDDPQGSLTRFGEGVALVEAFVAFYQLPLPPLLQDARCASSFSHLDDESKECMNGWVKAIFGSDGIEDAILLATPPQKLYSLTSTLIQQAILAVAASQIDLDTLHSGLSYFSQPLLSWCLGGVVSWLCKEIKRQGLLSALHLVVLQDLILGHSCPEALIRVNLKVLNDLLNDNSLIEVFQSSNFDLNGIKLKLNHFNLNELLSIPSINSSIPLNESLKLLRKIDENNSSINWEKTFFNSIENELKLKSNKKIIKIIFKEIFNFNFNFNKINNDNLIKFIPLILNFKFNKNQNILLLNTFINFSFNENFLKSLNYDYNNNNQEEKDLIEILKNSLIFNSIFNLNLNSNENKKDFLILNFINELEYLFNKSLKGLNEISIKEIIENENYNSNKKLNLNRKQQLILNIIKSLKNDDFFNL
Length971
PositionTail
OrganismKwoniella pini CBS 10737
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.08
Grand average of hydropathy-0.047
Instability index48.51
Isoelectric point5.10
Molecular weight108557.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09387
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.16|      15|      16|     232|     247|       1
---------------------------------------------------------------------------
  232-  247 (23.56/22.60)	QGpTSQIQMQN.GNVQS
  251-  266 (23.60/15.32)	QG.VQDIQMNNlSNDRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     108.66|      30|      30|     717|     746|       2
---------------------------------------------------------------------------
  717-  744 (40.63/18.77)	............................LKVLNDLLNDNSLIE....VFQSSNFDLNGIK
  772-  799 (22.57/ 6.89)	.............................KLLRKIDENNSSINwektFFNSIE...NELK
  800-  822 (22.83/ 7.06)	LK........................snKKIIKIIFK.....E....IF.NFNFNFN...
  896-  946 (22.62/ 6.92)	LNlnsnenkkdflilnfineleylfnksLKGLNEI....SIKE....IIENENYNSNK.K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.49|      27|      28|     463|     490|       3
---------------------------------------------------------------------------
   53-   70 (27.65/10.42)	..PSPPSLILS....Y..........LTNLLSSS
   89-  105 (21.74/ 6.80)	DLPPIPI.INSI.FNILAS...............
  472-  496 (32.86/17.40)	SHPHLPPLVHTIqYAYSAS.....aS....FSEE
  503-  534 (41.24/18.73)	SCPSIPP.PESV.FTYIASqpgllgCLTSTISAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     102.24|      19|      20|     826|     844|       5
---------------------------------------------------------------------------
  754-  768 (23.59/ 8.88)	E..LLS..I..PSI.NSSIP..LN
  826-  844 (36.52/17.85)	NDNLIK.FI..PLILNFKFN..KN
  846-  861 (22.45/ 8.09)	NILLLNtFI......NFSFN..EN
  877-  899 (19.69/ 6.17)	EKDLIE.ILknSLIFNSIFNlnLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.20|      16|      20|     191|     210|       6
---------------------------------------------------------------------------
  195-  210 (27.25/21.05)	PSLDVGL..EVGGLLPDL
  212-  229 (22.95/ 6.50)	EEINTHLrdHLSGLMTDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.08|      19|      20|     620|     638|       7
---------------------------------------------------------------------------
  620-  638 (32.34/25.41)	IEDAILLATPPQ.KLYSLTS
  641-  660 (26.74/19.53)	IQQAILAVAASQiDLDTLHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.05|      24|     367|     299|     333|       8
---------------------------------------------------------------------------
  303-  333 (31.39/41.65)	WilLLKAGKyltmdSSQFLSVLLEVGIQDLI
  680-  703 (43.65/22.67)	W..LCKEIK.....RQGLLSALHLVVLQDLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.21|      20|      20|     344|     363|      11
---------------------------------------------------------------------------
  344-  363 (38.37/23.94)	QNWNILVGIMPALLSWWKEH
  366-  385 (34.84/21.06)	EEFPFPVNITEILTDLFRNH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09387 with Med5 domain of Kingdom Fungi
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