<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09385

Description CMGC/CDK/CDK8 protein kinase
SequenceMVATGATAAAMLDPMHYYRAKRDRERRTVLKTYKILGFISSGTYGRVYKAVLLPSPASKGNTNKSTLPSSARAALSIPKDKLPSPTTSISSSNATISDPLNNPELCMRPGDLPAKEGDVFAIKKFKPDKEGDVLTYAGISQSGAREIMLNRELHHRNLVALREVILEDKAIYMVFEYAEHDFLQIIHHHSQTTRTPIPSPTLRRLLHQLLCGVHFLHSNFCLHRDLKPANILVNSSGVVKIGDLGLARLWHKPLAQGGLFGGDKVVVTIWYRAPELILGAKHYTAAVDIWAIGCIYAELLALRPIFKGDEAKMDGKKQLPFQRDQMGKICEVLGPVKADQWPGIVHMPEYKTYLSSGPYPNPNPLPSWYQHRSTSSQGYDLLTRLFEWDPARRLTAREALAHPWFQEEGGVAAKSVFEGSSVTYPTRRVTHEDNGDAKMGSLPPSMAHPRLPSSSNFRPASATLTGQPPPRKKARM
Length476
PositionKinase
OrganismKwoniella pini CBS 10737
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.08
Grand average of hydropathy-0.356
Instability index46.80
Isoelectric point9.58
Molecular weight52853.23
Publications









Function






Annotated function


GO - Cellular Component
euchromatin	GO:0000791	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09385
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.69|      35|      82|     341|     375|       4
---------------------------------------------------------------------------
  341-  375 (71.44/38.95)	WPG..IVHMPEYKTYLSSGPYPNPNP.LPSWYQHRSTS
  424-  461 (56.25/29.18)	YPTrrVTHEDNGDAKMGSLPPSMAHPrLPSSSNFRPAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09385 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VTYPTRRVTHEDNGDAKMGSLPPSMAHPRLPSSSNFRPASATLTGQPPPRKKARM
422
476










Molecular Recognition Features






MoRF SequenceStartStop




1) RKKAR
471
475