<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09384

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMSGHPTTEDALPITNTLFPPPPAYWQSYTEENIDRYESLSGKSLFEENKDTSEAENQDELDIDITEDEKTELEELKIRLDEPNAEWIEEDGRWMCFGNLFTTQPNIPTVESIGLPQMFQSNQQPQETLPTLLSSFLHTILLLLDVLTNSARTPNELMHAGWAHEGDQYIQHLSNLAATMMVTSNQLRQLQSESTLILIMEKEIEERRRQTQLLKSKCQEIAQNIKRLKSIKPNE
Length234
PositionMiddle
OrganismKwoniella pini CBS 10737
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.06
Grand average of hydropathy-0.674
Instability index67.16
Isoelectric point4.55
Molecular weight26943.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


ECO:0000256	RuleBase:RU364060

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09384
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.89|      12|      15|      26|      37|       1
---------------------------------------------------------------------------
   26-   37 (22.24/13.97)	QSYTEENIDRYE
   42-   53 (20.65/12.55)	KSLFEENKDTSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.51|      18|      20|      91|     108|       2
---------------------------------------------------------------------------
   91-  108 (36.38/19.88)	GRWMCFGNLFTTQPNIPT
  113-  130 (32.13/16.87)	GLPQMFQSNQQPQETLPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.91|       9|      24|     146|     157|       3
---------------------------------------------------------------------------
  146-  157 (10.77/15.52)	LTNSARTpneLM
  172-  180 (16.14/ 9.46)	LSNLAAT...MM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09384 with Med7 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSGHPTTEDALPITNTLFPPPPAYWQSYTEE
2) YESLSGKSLFEENKDTSEAENQDELDIDITEDEKTELEELKIRLDE
1
36
31
81










Molecular Recognition Features






MoRF SequenceStartStop




1) AYWQSYT
23
29