<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09380

Description CMGC/CDK/CDK8 protein kinase
SequenceMTAATTSSSAMVDPMHYYRAKRDRERRTVLKTYKILGFISSGTYGRVYKAVLLPSPKTSSSTTNKGTLPSSTRAALSIPKEKLPSPTNTSTTSSSLSGSSLDPLHNPELCMRPGDLPAKEGEVFAIKKFKPDKEGDVLTYAGISQSGAREILLNRELQHRNLVSLREVILEDKAIYMVFEYAEHDFLQIIHHHSQTTRTPIPSSTLRRLLHQLLCGVHFLHSNFVLHRDLKPANILVNSNGVVKIGDLGLARLWHKPLAAGGLFGGDKVVVTIWYRAPELILGAKHYTAAVDLWAIGCIYAELLALRPIFKGDEAKMDGKKTLPFQRDQMGKICEVLGPVKADQWPGIVHMPEWKTYQTSGPYPNPNPLPTWYHNRSSSAQGYDLLTRLFEWDPARRLTAREALAHPWFQEEGGVAAKSVFEGSSVTYPTRRVTHEDNGDAKMGSLPPSMAQPRLPSSSNFRPASATITHAQPARKKTRI
Length480
PositionKinase
OrganismKwoniella heveanensis BCC8398
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.08
Grand average of hydropathy-0.379
Instability index47.62
Isoelectric point9.62
Molecular weight53320.50
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09380
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.00|      25|      27|      53|      79|       1
---------------------------------------------------------------------------
   53-   79 (36.41/24.95)	LPSPkTSSSTTNkGTLPSSTRAALSIP
   83-  107 (46.59/23.80)	LPSP.TNTSTTS.SSLSGSSLDPLHNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.13|      15|      15|     346|     360|       2
---------------------------------------------------------------------------
  346-  360 (29.87/18.58)	PGIVHMPEWKTYQTS
  364-  378 (31.26/19.78)	PNPNPLPTWYHNRSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.62|      14|      15|     210|     223|       3
---------------------------------------------------------------------------
  210-  223 (27.09/17.67)	LHQLLCGVHFL.HSN
  226-  240 (20.53/11.80)	LHRDLKPANILvNSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.57|      21|      43|     247|     267|       4
---------------------------------------------------------------------------
  247-  267 (38.04/21.70)	DL.GLARLWHKPLAAGGLFGGD
  292-  313 (30.53/16.13)	DLwAIGCIYAELLALRPIFKGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.33|      18|     291|     119|     140|       5
---------------------------------------------------------------------------
  119-  140 (26.67/23.76)	KEGEVFAIKKFkpdkEGDVLTY
  411-  428 (31.66/17.56)	EEGGVAAKSVF....EGSSVTY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09380 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TSSSTTNKGTLPSSTRAALSIPKEKLPSPTNTSTTSSSLSGSSLDPL
2) VTYPTRRVTHEDNGDAKMGSLPPSMAQPRLPSSSNFRPASATITHAQPARKKTRI
58
426
104
480










Molecular Recognition Features






MoRF SequenceStartStop




1) PMHYYRA
2) TITHAQPARKKT
3) YKAVLL
14
467
48
20
478
53