<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09376

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSCEPHRDLLGYSPARPQTTIPGHWILDLPITTVTSDSSSDTHEQAAIHVRRFRATFLSVADDAGPGPSSSTKREGGHVDGSNTNLLEAAWRAIAEGQPSSSAAGTSDENLTMLSHPCGIITSELLGDARERVLWVFSTTAEDMVVPHGLQEMEPRLPPMNIHNLLVCSNHGQNPSCFYSSPEAHRQQPRSCEITLSSSEQARRNLDLLGAAVVERMAWKAGWRLCLHPSLESITPSLTTTLRPISPTRLLLSVTPSSRPTSSTSTSLEPLLLNPLRLPALRISNLSPSLTQESRLSAAFDLHYGYSWKSGRQEALTRARMLGETYTEWSVYWVPLITDQRTLSPKQLGKLSPRQLSDRWRQGSGVLTVWPTHLAEPFYLNTTAPPSNPVVLGDYNVKTKSSDLLDIASDVFDFLSNYREPEVVEEVEDDPDPVEEDVTMDGESNIEPNSITDGLDTGNDRSPHSDIDDLFSAHSDSPGNDGTPLATVKPSSPLRIDEKMVEAVDYEPPRAPVRREQGSEAEEKPEQREEIMVTEDDFAFFDSPTDQVDGLSFVGLLNDGNAPPNGHAMTADEGMDIDLNAIFGGTIDGFSKGCEGSPEHPAQSAQSMNMEAPAAPDAAGTSVERVPQPAQIDDRPVEASTSTEGVIASQPVQLPPSPALSLHKRSYSTTDLVPPSFSPLPLLPLQSSQYYNYAFPSPAPTPSSLREDLVQRLKPPQSRTATYADVWEMESEPSAMDEEEEFTGPPTPESAYSDESETEDRPAEKKGSEEDINDFGGVQCLSTEWLEYIYLPEKVQTLAKQWDLSWVTSSLLPVAMQEADAGIASDSASAIALKGIDCVRFVRDLLSNKVSRSICASGANEKDFAAMNAQSLVEQGVVLSDLSQSPSSSLAQPQIHAGYFDSVIKLSISALHYWVEIGLQPQGGPKDVEGVVVCDKDEVSKAAGGQLLLEVKRAWESLRLGKYRVSELAGNNRGVVSVSSSGISETVADLLNQVSHNTVIYVLLPPESSSIISVIRGLYSLALSPSPSTIMRLIPRHALSQDRYRELAMDIYDGLPLPVRAISHAALDPNLDHNPDQSRVVPAHAFTLARTELPKPEFSMSWPLKSYDVLNTQRSTHGCYTIVEEYDVMIACVMDDLGEAFELNIWQDIGKMEVKSRVKQVFEWFKDRTEEWIIQWKGSVTRVGAVALDEIRIWNNILDKTSLPLTFLVVDPPSHGPDPSVNQIPRPRGLTNIPPATMNDPNASLIDLSLTGQITAFSSRLPLTMQAVKPDYERNGASNPYQTDIVYPQSCFLLTISDEMGHKSISTVYNVMNHSKGLRSELEARGKDHNKKLGEELYRLNCLIRRRHGLEGMDGILSLAERGLRGLSSMGQGKEGGVVD
Length1380
PositionKinase
OrganismKwoniella heveanensis BCC8398
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.06
Grand average of hydropathy-0.386
Instability index55.76
Isoelectric point4.80
Molecular weight151249.61
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09376
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     348.57|      86|     514|      76|     163|       1
---------------------------------------------------------------------------
   76-  163 (147.66/80.63)	GGHVD.......GSNTNLLEAAWRAIAEGQPSSSAAGTSDENLTMLSHPCGIITS.........ELLGDA.RERVLWvfSTTAEDMVVPHGLQEMEPRLPPMNIH
  165-  238 (84.57/40.29)	.................LLVCS....NHGQ.NPSCFYSSPEAHRQQPRSCEITLSsseqarrnlDLLGAAvVERMAW...KAGWRLCLHPSLESITPSL......
  584-  663 (116.34/58.15)	GGTIDgfskgceGSPEHPAQSAQSMNMEAPAAPDAAGTSVERV...PQPAQI................DD.RPVEA...STSTEGVIASQPVQ.LPPS.PALSLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.06|      12|      16|     778|     789|       3
---------------------------------------------------------------------------
  778-  789 (23.38/15.59)	VQCLSTEW.LEYI
  795-  807 (18.68/10.83)	VQTLAKQWdLSWV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.21|      15|      16|     265|     280|       4
---------------------------------------------------------------------------
  265-  280 (21.86/17.81)	StSLEPLLLNPLRLPA
  284-  298 (25.36/15.34)	S.NLSPSLTQESRLSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.21|      13|      16|     490|     505|       5
---------------------------------------------------------------------------
  490-  503 (19.29/19.50)	PSSPLRiDEKMVEA
  509-  521 (23.92/ 9.87)	PRAPVR.REQGSEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.09|      56|     506|     683|     750|       6
---------------------------------------------------------------------------
  683-  750 (83.62/54.23)	LPLqssQYYNYAFPSPAPTPSslredlVQRLkpPQSRTATYADVWEMeSEPSAMDEEEEFTGPPTPES
 1203- 1258 (102.47/43.16)	LPL...TFLVVDPPSHGPDPS......VNQI..PRPRGLTNIPPATM.NDPNASLIDLSLTGQITAFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.24|      19|     681|     344|     362|       9
---------------------------------------------------------------------------
  344-  362 (37.28/21.26)	SPKQLGKLSPRQ.LS.DRWRQ
 1026- 1046 (27.97/14.14)	SPSTIMRLIPRHaLSqDRYRE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09376 with Med13 domain of Kingdom Fungi
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