<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09375

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASLARGSGGYPSDRQGQGGPIASTSASTSDNPVYPSSSKAAVVIKNPQLTDEPYFAYPTPTSEQIEEELPPYFESENFPLGPLLDRLVRRGYGDLRYLLGEVLPPLSTRQRPKHIIDYAKTTRQSLLKYLAVLRWKTSVDLSITSQQSSIPGQTAPQQQQQQPGLTNFPTPHSNGDPNDTSPSSLAGKGKGKAAVNGDTIGDEVVRGKVTDARRIAHFMEHQNKQHDDAVEHIRHVTKVVEGLRERNPDLLTALALLTTGTYSRLPTSITEPYLPKPPLTNSAVLTILRRLNRHIRYRLRCLDYVPSELSVESIRDGQVYLRGGGEYGWKARMTVVGFGDDSRWWLTGVEWSWRNKRKSVHDPGGDNSPSFEGKRFEGEERQGILDLANMDVLAPKEVIHVGNDKTDRPTTSKTAGVKDQAVSNAGKAVDSPLVRLYNFLQHLSLSYQLEILFSQAMALSQGRWRGQLAVEIDRANSVLRVKYWIRPRPAQVPQQQQAAVGKRPAPSIAPAASRSPMVGGILSITLAEPTAAANETDDLFGSIAAGGMRANERILRLRLMVKWEIGEIGIGGGLKVGDVMDGGLLRIDPGAISLDDILATSTRAHAAHLTRSHTSTLLSSPRFIQTLLNQPTLREAEDISSTLPLTLHIPLPSHQRVTTLIVGVSSLNGLLEIEDDGSTGNEARATQVRTAAGSVNQGKTRLVDEIGRLTIAIIMENMEMQMRQLGWRPARRLALRSQDLAKADIHPLTTIFVPLPSSTMHYFIARATPSGLSFELLRLARVPIENGLGVGLKLAIGDRTALDLEKLKTRRKGKHLDAPTGSTPASNFEVENRDLKDLFLFSNALVAQAIIEQQLKERSIPYTIQYPPATGPGAPRSTSALAGMVPTVCVDVRDLLRDGKSGGAAVEVALPKVGMQIENWWKGGICEVTTIVQLRHQSPMAQATTSASSDGDSSTTPKDSDARPEGISFDPSSSIVKFRAKDISRCVPVFLEQWERLSKVIVVAGEVNRLNKLAEFKDVQLLSFDLHTATLSYAKGYNASITYTPVDDSYQVTQEAIQGQQETQRNPHSILAPLLSAKLNELTSAPAAGAKRGAVAREFIGLLKSTLPFLVELPALQEIGWGLVVLGVSIFRIVRDWEGKRYALDITLLPSLTHYLIQDAHTPKGPDHTIDNYVGQLTPISDLRSPTSTSTRPQEDIIQHIFESEKSFKVDVEQLKKEVRRAGTNRAAAGGALMMPPLMKLDGGKSLAVAVERVGRVVRLYAEEIGKLASTRRSATAVQGQGTAQPQPQTHAATLTPTPTLSTIKENIKVE
Length1312
PositionTail
OrganismKwoniella heveanensis BCC8398
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.05
Grand average of hydropathy-0.314
Instability index45.37
Isoelectric point9.14
Molecular weight143255.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09375
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1153.09|     312|     543|     408|     761|       1
---------------------------------------------------------------------------
  157-  493 (404.21/302.68)	PQQ...................QQQQPGLTNFP.T...PHSNGDPNDTSPSSLA.GK..GKGKAAVNGDTIGDEVVRGKVTDARRIAHF.MEHQ..NKQHDDAVEHIRHVTKVVE.GLRERNPD.......LLTAL....ALLTTGTYSRLPTS..ITEPYLPKPPLT.NSAVLTILRRLNRHIryRLrcldyvPSELSVESIRD..G.QVYLRG......GGEYGWKARMTVVgfgddsRWWLTGVEwswRNKR.KSVhDPGGDNSPSFEGKRFEGEERQ.G.......I.........L...DLANMDVlAPKEVIHV.......gndktdrpttsktagvkdqavsnaGKAVDSPL....VRLYNFLQHLSLSYQLEILFSQAMALS....QGRWRGqlaveidransvlrvKYWIRP...RPA...QV
  494-  831 (463.71/317.09)	PQQ...................QQAAVGKRPAP.SIA.PAASRSPMVGGILSIT.LA..EPTAAANETDDLFGSIAAGGMRANERILRLRLMVK..WEIGEIGIGGGLKVGDVMDgGLLRIDPGAISlddiLATSTRAHAAHLTRSHTSTLLSSPRFIQTLLNQPTLR.EAEDISSTLPLTLHI..PL......PSHQRVTTLIV..G.VSSLNGLLEIEDDGSTGNEARATQV......RTAAGSVN...QGKT.RLV.DEIGRLTIAIIMENMEMQMRQlGwrPARRLA.........LRSQDLAKADI.HPLTTIFVPLPSSTM....................hyfiARATPSGLsfelLRLARVPIENGLGVGLKLAIGDRTALDleklKTRRKG...............KHLDAPtgsTPAsnfEV
  832- 1108 (285.17/168.22)	ENRdlkdlflfsnalvaqaiieQQ..LKERSIPyTIQyPPAT.GP..GAPRSTSaLAgmVPTVCV.DVRDLLRDGKSGGAAVEVALPKVGMQIEnwWK......GGICEVTTIVQ..LRHQSPMAQA.....TTSASSDGDSSTTPKDSD..ARPEGISFDPSSSIVKfRAKDISRCVP....V..FL......EQWERLSKVIVvaGeVNRLNKLAEFKDVQLLSFDLHTATL......SYAKGY.N...ASITyTPV.DDSYQVTQEAIQGQQETQ.RN....PHSILApllsaklneLTSAPAAGAKR.GAVAREFIGLLKSTL.........................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.19|      58|    1127|      49|     107|       2
---------------------------------------------------------------------------
   49-   80 (47.32/19.98)	...................................................QLTDEPYFAYPTPTSEQIEEELPPY.FESE.NFP
   81-  107 (26.19/11.29)	LGPLLDRLVRRGYGDlRYLLG.EVLPPL.........................................................
 1127- 1210 (75.67/36.43)	LGVSIFRIVRDWEGK.RYALDiTLLPSLthyliqdahtpkgpdhtidnyvgQLTPISDLRSPTSTSTRPQEDIIQHiFESEkSFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.38|      14|    1263|      16|      29|       3
---------------------------------------------------------------------------
   16-   29 (26.39/16.06)	QGQG..GPIASTSAST
 1280- 1295 (23.99/13.79)	QGQGtaQPQPQTHAAT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09375 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASLARGSGGYPSDRQGQGGPIASTSASTSDNP
2) TRRSATAVQGQGTAQPQPQTHAATLTPTPTLSTIKENI
3) TSQQSSIPGQTAPQQQQQQPGLTNFPTPHSNGDPNDTSPSSLAGKGKGKAAVNGDTIGDE
2
1272
145
33
1309
204










Molecular Recognition Features






MoRF SequenceStartStop




1) EELPPY
2) EPYFAYPTP
3) VKYWIRPR
68
53
482
73
61
489