<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09372

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAYDELSLPELIGRAYARAVPAKKLVKLVQSRLSGSNLEETDDQLAAALIPYLLPSPPSLLLSYLSELLTSHTPLLTTKTIFIHLLFYIAEHDIPPIPSLLSVSTILASSPLGLEEGSIPSLLTIPNNKARESDIPEVGTSASASTSTLTAPKQISTLSLLLPLLRICASTPPSPLSNLVGRAILHLSPFPAPSLDVGLEAGQLLPSLPEEISVPLRSTLSGLMADLATQDMQSTSALASADPGQDSQMAQQGSQQVQNAIRERLPLSQTLALLLERARRASRWHVSAESDASTPQPGLLDLLRTGPSLEYEPTEFMSTLLQVSLKALLDTSVDGSSTEAGEWWNLVMDGVLGLIAWWKTHPEGKFPFPEDIPSLFSMVFNNLSQQMTAFSEAILLRYATLVQQSESEDDSSAFTPVEGWSIRPMQETLLSRLVQLGIIATDQATIVAPGVPVHPFTPGESLLNRLAAESHHHLPPLAHVIQFAAGASSSFASDLLQTVKACPSIPPPENLFTFVASQPTLITALTGSVSPAEFGDLLVKHLLDAPLDESTRMDDPQGSLTRFGEGVVLVEAVVAHFELPLPPLLVDARSAWSYSHLSNEDKETMNGWVKAIFGSDGIEDQILLATSPQTMYKLAPTLIQQAIAATTTGQMDLDTLHSGLSYFSQPLLSWCLGGVVSWLCHEIRRQGLLSALHLVVLQDLILGHTCPEPLLRVTSDMLNNILSSTSGHGDVFQSSNFDVLGIRSKLDSIGLTLSPIVIETPLRTALQVARQLDLAPAGWDSALLDALSNSIAVIGEVATVKKLMDEIALSSTIAMPMTGTADSLTAFIPLLFSLRLSRASNPLVQALIRGWLPDLCQHNQTATSVSGELIGWVVKRSLVLASDISGQQGDGQVDANKALDTLVNGLMDELEYELSRLAPRTQHLARDQQQQQGVTDGEDAGSKRSLQTKTKGSKRGGTGDTSATGKREMIEGLIKLFRDDEDLRARFGSLRRLDGLL
Length997
PositionTail
OrganismKwoniella heveanensis BCC8398
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.05
Grand average of hydropathy0.058
Instability index50.83
Isoelectric point4.90
Molecular weight107277.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09372
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     582.50|     156|     162|     121|     281|       1
---------------------------------------------------------------------------
    8-  139 (108.33/71.88)	.......................................LPELIGRA...YARAV.PAKKL...VKLVQSRLSGSNLEETDdqlaaalIPylLPSPPSLLLSYL.SELLTSHTP...LlttktifihllfyiAEHD................IP..PIPSLLSVSTILAsspLGLEEGSIPSLLTIPNnkarESD..IPEVG
  140-  298 (254.43/166.97)	TSAS...ASTSTLTAPKQIStLSLLLPLLRICASTPPSPLSNLVGRAI.LHLSPF.PAPSL..DVGLEAGQLLPSLPEEIS.......VP..LRSTLSGLMADLATQDMQSTSA...L..............ASADPGQDSQMAQQGS..QQVQN.AIRERLPLSQTLA...LLLERARRASRWHVSA....ESDasTPQPG
  305-  432 (163.92/100.31)	TGPSleyEPTEFMSTLLQVS.LKALLDTSVDGSSTEAGEWWNLVMDGV.LGLIAW.WKTHP..E.....GK.FP.FPEDI.........P....SLFSMVFNNL.SQQMTAFSEailL..............RYATLVQQSESEDDSSafTPVEGwSIR...PMQET......LLSR.........................
  436-  510 (55.82/26.67)	............................LGIIATDQ....ATIVAPGVpVH..PFtPGESLlnRLAAESHHHLPPLAHVIQ.......FA.......AGASSSFASDLLQTVKA...C..............PSIPPPEN..............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.96|      16|      18|     751|     766|       2
---------------------------------------------------------------------------
  527-  542 (23.88/ 9.04)	GSVSPAEFGDLLVKHL
  751-  766 (25.00/ 9.76)	LTLSPIVIETPLRTAL
  772-  787 (27.07/11.09)	LDLAPAGWDSALLDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.51|      56|      69|     858|     926|       3
---------------------------------------------------------------------------
  867-  926 (80.29/68.23)	GELIGwvVKRSLVLASDISGQQGDGQVDANKALDtLVNGLMdELEYELSRLAPRTQHLAR
  937-  992 (93.23/47.41)	GEDAG..SKRSLQTKTKGSKRGGTGDTSATGKRE.MIEGLI.KLFRDDEDLRARFGSLRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.55|      45|     162|     630|     693|       4
---------------------------------------------------------------------------
  631-  681 (76.65/78.01)	MYKLAptlIQQAIAATTTGQMDLDT.....LHS.GLSYFSQPLLSWCLGGvvsW...LCH
  804-  857 (65.90/29.54)	MDEIA...LSSTIAMPMTGTADSLTafiplLFSlRLSRASNPLVQALIRG...WlpdLCQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09372 with Med5 domain of Kingdom Fungi
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