<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09369

Description CMGC/CDK/CDK8 protein kinase
SequenceMAAAMVPGSSMIDPMHYYRAKRDRERRTVLKTYKILGFISSGTYGRVYKAVLLPSPSSSSTSKSNKSILPSSARAALSIPKDKLPSPTTSTSSNSNTPILDPLNNPELCMRPGDLPAKEGDVFAIKKFKPDKEGDVLTYAGISQSGAREIMLNRELNHRNLTALREVILEDKAIYMVFEYAEHDFLQIIHHHSQTTRTPIPSPTLRRLLHQLLCGVHFLHSNFVLHRDLKPANILVNSAGVVKIGDLGLARLWHKPLAQSGLFGGDKVVVTIWYRAPELILGAKHYTAAVDQWAIGCIFAELLALRPIFKGDEAKMDGKKQLPFQRDQMGKICEVLGPVKADQWPGIVHMPEYKTYLSSGPYPNPNPLPTWYQHRSSSSQGYDLLTRLFEWDPARRLTAREALAHPWFQEEGGVAAKSVFEGSTITYPTRRVTHEDNGDAKMGSLPPSMAHPRLPSSSNFRPASANLTAQQPARKKTRM
Length479
PositionKinase
OrganismKwoniella bestiolae CBS 10118
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.08
Grand average of hydropathy-0.382
Instability index49.82
Isoelectric point9.62
Molecular weight53348.71
Publications









Function






Annotated function


GO - Cellular Component
euchromatin	GO:0000791	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09369
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.01|      41|      43|     224|     266|       1
---------------------------------------------------------------------------
  200-  221 (20.53/ 8.14)	........................IPSPTLRRLLHQLLCGVHFLHS.
  224-  266 (63.35/49.16)	VL....HRdlKPANILVNSAGVVKIGDLGLARLWHKPLAQSGLFGGD
  268-  312 (61.13/40.82)	VVvtiwYR..APELILGAKHYTAAVDQWAIGCIFAELLALRPIFKGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.81|      29|      29|      54|      82|       2
---------------------------------------------------------------------------
   54-   82 (50.05/31.54)	PSPSSSSTSKSNKSILPSSARAALSI.PKD
   85-  114 (51.75/32.86)	PSPTTSTSSNSNTPILDPLNNPELCMrPGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.12|      48|      82|     344|     398|       3
---------------------------------------------------------------------------
  344-  398 (88.50/55.65)	WPG..IVHMPEYKTYLSSGPYPNPNP.LPTWYQHRSSSSQgydlltrLFEWDPARRLT
  427-  477 (77.62/37.89)	YPTrrVTHEDNGDAKMGSLPPSMAHPrLPSSSNFRPASAN.......LTAQQPARKKT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09369 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPKDKLPSPTTSTSSNSNTPILDPLNNPEL
2) ITYPTRRVTHEDNGDAKMGSLPPSMAHPRLPSSSNFRPASANLTAQQPARKKTRM
79
425
108
479










Molecular Recognition Features






MoRF SequenceStartStop




NANANA