<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09364

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASSSAHPPSTSGPGASSSGGVNANPPIQASTSTTLPTARPRNPQLSNDPWFAYPTPTPEQIEEELPPYFEGENVPLGPLLDRLVRKGYGDLRYLLAEVLPPLSAKQKPKHIINYATTTRQALLKYLAVLRWKNAVDLPSIPSSSSGGKGQQSGTYTNQNGITNFPTPHSNGDDTSPPSILSNNKGKGKAIAAGEEIPVKGKVSDSRRLAQFMEHQNKQHDDAVIHLKHVTKLVESLRERNPDLLTALSLLTTGTYNRLPTNIIEPFIPKPPLTNSSILSLLKKLNRHVRYRLRCVDYLPPDLVVEGISDGQVYLRGGGENGWKARMTIVGFGEDSKWWLTGVEWRWRNKDRGVNDPGGEEPTKGEGKRFTGEERQSILDLANLDILPPREVDIQQRNQKKDQVVEKEKNVVDAPLVRIYNFLQHLSLSYQLEILFSQAMALSQGKWRNQLRVEIDRENKTLKVKYWIRPRPAIIAQQQQQAAVGKRPAPAASLGTARTPLVGGILSITLGENGVQPNETDSILGDVSSGGLIPNERVLRLQLGVKWEVGELGIGGGLKVGDVMDGTVLRIDSASLDMENLLMTSARAHAAHLTRVQASSLISSPKFILSLLNSPTLQESEDQNSPRPLTLRIPLPSRQRISSLLIGVSAYNGYIEIEDDGSIGNEGRANRVEMATKSINDGKTRLVDDIGRLTVAVVMENLEDQMRQLGWKPIRRLALRSQDLAKVHLHPATTILIPVPSSLSHYFVTKVTQNGLAFELLKTIKLPIENGLGVGTKFAVGDRVPLDLEKLRAGRKEKGEITGSPFEIGNKDLRKLYILSNALVAQTIIEQQLKERNIPFTAQYPPTTGPGAPRSSSALAGLVPTICVDVRDLLRDGKTGAAADVAMPKVGMQIENWWKGGRCEVTTIVQLRQQSSMSQASSSNGSQPHSEDISFDPSSSIVKFRAKDIERCVPAFLEQWERLSKVIVVAGEVNRLNKLAEFKDIKMLSFDLRTATLSYSKGYNASITYIPTNDSYQVILTSDQPSIPTSVNTDSSLRIQQPHYNPHERLSQLLSARLTQLASEPVESQGSIGKEFFRLLKNTLPFFEQVEKIEKRGWNLLVMDLREWRIVRDHGGRRYALDIILIPSLSHYLIQSAHKPRGPDRRVVDLTGKLNELPLSKIIPKVFDQQKALSLVSTSNGRKGDMPPLMKLDQNTSLLCQVGLVEGVLQGVLNEVDLVIGKD
Length1223
PositionTail
OrganismKwoniella bestiolae CBS 10118
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.05
Grand average of hydropathy-0.373
Instability index43.58
Isoelectric point9.28
Molecular weight135019.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09364
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.45|      58|     127|     905|     965|       1
---------------------------------------------------------------------------
  905-  965 (92.58/67.56)	VTTIVQLR.QQ......SSMSQASSSNGSQPHSEDIsfDPSSSIVKFRAKDIERCVPaFLEQWERLSK
 1031- 1095 (85.87/52.61)	VNTDSSLRiQQphynphERLSQLLSARLTQLASEPV..ESQGSIGKEFFRLLKNTLP.FFEQVEKIEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.59|      18|     385|     710|     748|       2
---------------------------------------------------------------------------
  627-  646 (27.78/ 9.74)	RPLTLR................IPLPSrqRISSLLI
  715-  748 (24.81/55.88)	RRLALRsqdlakvhlhpattilIPVPS..SLSHYFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     298.00|      74|     126|       9|      84|       3
---------------------------------------------------------------------------
    9-   84 (130.55/77.16)	PSTsgPGASSSG.GVNANPPIQASTSTTLPTA.RPRNPQLSNDPWFAYPTPT....PEQIEEELPPYFEGENVPL.GPLLD..RL
  139-  209 (94.71/50.07)	PSI..PSSSSGGkGQQSGTYTNQNGITNFPT......PHSNGDD..TSPPSI....LSNNKGKGKAIAAGEEIPVkGKVSDsrRL
  220-  285 (72.75/36.21)	...............HDDAVIHLKHVTKLVESlRERNPDLLTALSL.LTTGTynrlPTNIIEPFIPKPPLTNSSI.LSLLK..KL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.54|      32|     125|     526|     568|       4
---------------------------------------------------------------------------
  527-  562 (42.10/59.12)	VSSGGLiPNERVLRLQLGVkwEVGeLGIGGGLKVGD
  751-  782 (55.44/30.25)	VTQNGL.AFELLKTIKLPI..ENG.LGVGTKFAVGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.99|      25|     125|     667|     714|       5
---------------------------------------------------------------------------
  294-  324 (37.99/10.47)	RCVD...YLPPDLVVEGISDGqvyLRgggENGWK
  685-  712 (40.00/22.48)	RLVDdigRLTVAVVMENLEDQ...MR...QLGWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     248.75|      84|     387|     407|     503|       9
---------------------------------------------------------------------------
  407-  503 (122.31/104.09)	KEK.NVVDAPLvRIYN.FLQHLslsYQL.EILFSQAMALSQGKWRNqlrveIDRENKTLKVKYWIRPR.........PAIIAQQQQQAAVGKRPApAASLGtarTPLVG
  796-  891 (126.44/75.54)	KEKgEITGSPF.EIGNkDLRKL...YILsNALVAQTIIEQQLKERN.....IPFTAQYPPTTGPGAPRsssalaglvPTICVDVRDLLRDGKTGA.AADVA...MPKVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09364 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MASSSAHPPSTSGPGASSSGGVNANPPIQASTSTTLPTARPRNPQLSNDPWFAYPTPTP
2) SIPSSSSGGKGQQSGTYTNQNGITNFPTPHSNGDDTSPPSILSNNKGK
1
140
59
187










Molecular Recognition Features






MoRF SequenceStartStop




NANANA