<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09361

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAHEDLTLSELIGRAYARALPPVKFTKLVQARFSGKEDLQYPDEIISSALLPFLLPSLPSLILSYLSHLLSSTSLLNSQTIFTHLLFYIHTNDLPPTSSIVALTNILTIHPTGLDNSIPSLLSPPPSDSQNGGPSSPKTSNQISTLSLLLPLLRLSSSNPPDTVSSLNTYLSKFISVLSAFPSPSLDVGLEAGQLLPNLPEEIGTPLRGLLSGLMTDLDNQDMINQQQSGVNEDVQMDNVISQNIKPGEGSRLPLKQTLAFFLEYIKRTNKLSRKDTQDGYRSLVKVGKEITNDPEEFLRVLLEVAIQTLVGSDANMLDAAQYWGVLIEDICGLLGWWKKHGEEGFAFPSDVVTPLSIVFSALSASMQTFSDQLTQRYSNLIQQAENEDDGSAFTPLEGWHLLSLQETLMSNLVQLGALDSQQASAIAPGVNVHTFTPGESLINRISFESHPHLPPLVHTIQYAYGASSTFSAEFIQIIKSCPNVPPPENLFNYIASQPGLLGALITQISPLALLDIMQKQLLDLGVDEQGRNDDPQGSLTRFGEGVALVEAFVAYHQLPLPALLQDARCAVGFSHLDEESKECMNGWVKAIFGSDGIEDAILLATPPQKLYKLSPTLIQQAILAVTASQIDLDTLHSGLSYFSQPLLSWCLGGVVAWLCREIKRQGLLSAIHLIVLQDLILGHSCPEALIRVNSTALNELLSPNSGLAPVIESSSFDLAGIRSKLDSLGLNASLPSNTMDLNGALGVLRQIDLAQLGWERGLLDPLEKEVKWRGRVEVTRVIMEELSNPQMIVGDNLAGFTPLLLAISIDQDGGSRTLLENLIHHSEWLLSPSPPITHLLKRSLVFYSALGRGEKIILELADELEYLVSLPVRPSENPQGQGTKQRKIQDGLFTQVSTGQREVLEGLIRGLRDDEDLRSRFAVVGRLDRVL
Length932
PositionTail
OrganismKwoniella bestiolae CBS 10118
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.06
Grand average of hydropathy0.019
Instability index46.75
Isoelectric point4.88
Molecular weight101792.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09361
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     221.67|      68|     102|      48|     116|       1
---------------------------------------------------------------------------
   48-  116 (112.11/61.62)	SALLPFL......LPSLPSLILSYLSHLLSSTSLLNSQTIFTHLLFYIHTNDLPPTSSiVALTNILTIHPTGLDN
  147-  220 (109.56/56.60)	SLLLPLLrlsssnPPDTVSSLNTYLSKFISVLSAFPSPSLDVGLEAGQLLPNLPEEIG.TPLRGLLSGLMTDLDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.25|      89|     106|     369|     474|       2
---------------------------------------------------------------------------
  376-  468 (140.18/103.39)	QRYSNlIQQAENEDDGSAFTP.LEGWHL.....LSLQETLMSNLVQLGaLDsQQASAIAPGVNVHTFTPGESLINR.ISFESHPhLPPLVHTIQYAYGAS
  480-  575 (137.07/83.85)	KSCPN.VPPPENLFNYIASQPgLLGALItqispLALLDIMQKQLLDLG.VD.EQGRNDDPQGSLTRFGEGVALVEAfVAYHQLP.LPALLQDARCAVGFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.15|      73|     106|     624|     702|       3
---------------------------------------------------------------------------
  624-  702 (108.11/81.90)	LAVTAS....QIDLDTLHSGLSYFSQPLLSWcLGGVVAWLCREIKRQGLLSaIHLIVLQDLilghSCPEALIRVNSTALNELL
  729-  805 (118.03/70.63)	LGLNASlpsnTMDLNGALGVLRQIDLAQLGW.ERGLLDPLEKEVKWRGRVE.VTRVIMEEL....SNPQMIVGDNLAGFTPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.31|      20|     583|       9|      28|       4
---------------------------------------------------------------------------
    9-   28 (35.15/24.83)	SELIGRAYARALPPVKFTKL
  595-  614 (35.16/24.84)	SDGIEDAILLATPPQKLYKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.27|      13|     193|      34|      47|       5
---------------------------------------------------------------------------
   34-   47 (19.94/17.03)	SG.KEDLQYpDEIIS
  229-  242 (20.33/11.14)	SGvNEDVQM.DNVIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.02|      25|     748|     121|     145|       7
---------------------------------------------------------------------------
  121-  145 (47.10/25.80)	LLSPP..PSDSQNG.GPSSPKTSN....QIST
  868-  899 (30.92/14.38)	LVSLPvrPSENPQGqGTKQRKIQDglftQVST
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09361 with Med5 domain of Kingdom Fungi
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