<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09360

Description Uncharacterized protein
SequenceMPLPTRYPPGVNPYAPSTSSKTPRTGHRPHPPAKPPKALLDDVDIEDFHPPEWRTVLNSRVDLGYPDFYPSRPGFDQPEDVLTEENVKNGFTGRNFIAVGAEVFSMHGPIHNHLSSGGLNLLQNLGKELIEKRQEMMPKIGERSFRIPVRVTYNDTKRLQFLNDLANPNVPLYKLMRTPVPHGFKGIELLDSMFSPNIGPSASGHNRTPSGSSNNNKIPSNPIPLDRALWFIRVLGSNEISAHRSRTQPQHHQTASANPNTPVGVSPAAAATPSSTTTIITAPTLQVSSNDWYTQEFTNTFISWLRVQLGQLALPNINAKSTVKPGVPPPKTLGGTLGDEKLRSRWLTKWEYSTQLMRELHRRRLLSSRLLSGWMADYLGYANLAQLGFVVQMIGEYLGDMVEHVCNARQCVRNACEKLKEIRSSPASDPLAKVDAMLTSVIKKLDSICEDTNMLELTRSFFDGGSSATNSSPDISRLEDKIFILLNWAMGLFQLGSHRPYAVYTLLKLWHDQHEEHQAKQAEPIVIDLFPLLYKWLDTSSAARKEENVQAIGITIGEITRQGMFSYGRYLQALIAKGQTARNHIPGQPQSHHLALLRALPIFVIAKDLVQQRRIALCGDDVDNRMRDDAVETALMDQFREEVMEYVPEVFGEIIYKNSAALRNVIDYQIPCSTKMSRYLYVQARFWLAPEAGRYLKGDSQTPPMDASTFARIMQVFRTCRGYATIADFIIRALQDSEDEEILDVIIDIVRRDADVWTAMDGWSRLGDKLLDRYHTLQTQGRHHLRTLQLLEYLVEKGRLTADEEDEVKHIRSEIPKDTPPKLEFKESLHSLQQVLSGAKEDHAIALAPKLFVRHGSFSNWSNQWWSTIIQHLQHPSSHVSQDSTLRTIDSHILAVRRDAQNQLEPVISSWLDGLTPTALVDMFGKRSGGLISPLLLELAVERCVSTLTLLEKLIYPIWKYTSSIILTPRRRLSSKQINAVNNTINMASQLLVSPPLIATLPPTIPTHSLIVLAFRQAVFCGVSVQNLIKHLPLLVVLLKSAMLSENTNSTISSLLRCLAMTAEFKTAAFRNLNILKDTFLSTEWSKPSSAHGLEAGMEDTLKLIMSEKQPNSSTPASKSRVTTFDNTARLSAWRWTRIVLEMRSDFKGLATRINNGEDVIEARQILHRQVLATLDRAATADDTDLLCEAFRGMDSVVTQEILVAGLDRLSNLLSQAIGAETQNHLEEHIKSIEQILRILDSTYTQRSSEPINDNTVLSSRHRLLDLLAVGLQSVERQLSDSDLVLHHDISTPPQPGHLLKTILDLLKFTLGLLVLDSNSPTTPKPNFPNLAVAFFRVMLSCHNVLDDEGAQMMSDMLSYIIDSTPSQSKISVQTALLSETVSSTTQDILSFKPILGKSLPYLPPTKRNMALLSTSADEDNLDSAVMMEERKWELFQQINPIPKKPNHQDLYLLNKPTVKDTSSISLGLFGPKFTRDVLPNLANRWQDPASGTAAAEGGAEEEEQDEEEEGNLPWENYASERTLGDGMNESPFERQKSTLLFDNAEELSLADQNGIEEDEVEYPRSGSISASVGTVKRRMSTRSQSSPTKPLAHLPKRGGQGGTNKDPISIDEDSSASGSNSDSDDSTSSEEVLEVQKPAAKKPRTSSTSTGGKRPATAGKAPARKSVGGKSVARKNTGGKSTRGTGGKAPRGRRKSSLVD
Length1701
PositionKinase
OrganismKwoniella bestiolae CBS 10118
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.06
Grand average of hydropathy-0.379
Instability index50.37
Isoelectric point6.66
Molecular weight189163.70
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09360
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.73|      20|      25|    1641|    1663|       1
---------------------------------------------------------------------------
 1624- 1643 (28.45/10.86)	SDDSTSSEEVLEVQKPAAKK
 1647- 1666 (36.28/26.55)	SSTSTGGKRPATAGKAPARK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.20|      12|      15|    1339|    1352|       2
---------------------------------------------------------------------------
 1339- 1352 (16.19/17.10)	MLSchNVLDDEGAQ
 1357- 1368 (22.01/12.79)	MLS..YIIDSTPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.32|      13|      17|      30|      42|       3
---------------------------------------------------------------------------
    7-   19 (25.88/14.72)	YPPGVNPYAPSTS
   30-   42 (25.44/14.32)	HPPAKPPKALLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.20|      15|      17|    1500|    1516|       4
---------------------------------------------------------------------------
 1500- 1516 (23.10/19.85)	AEEEE.QDEEEEGnlPWE
 1519- 1534 (23.10/12.47)	ASERTlGDGMNES..PFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     440.38|     122|     124|     512|     634|       6
---------------------------------------------------------------------------
  499-  621 (180.32/115.97)	.....RPYAVYTL......................................lklwhDQHEE..H...QAKQAEPIVIDLF.PLLYKWLDTSSAARKEENVQAIGITIGEITR....QGMF....S..YGRYLQALIAKGQTARNHIPGQP.....QSHHLALLRALPIFVIAKDLVqQRRIALCGDD
  622-  740 (156.11/95.77)	VDNRMRDDAVETA.........................................lmDQFRE.........EVMEYVPEVFgEIIYK...NSAALRNVIDYQIPCST..KMSRylyvQARFwlapE..AGRYL.....KGDSQTPPMDAST.....FARIMQVFRTCRGYATIADFI.IRALQDSEDE
  747-  898 (103.94/60.87)	IDIVRRDADVWTAmdgwsrlgdklldryhtlqtqgrhhlrtlqlleylvekgrltaDEEDEvkHirsEIPKDTPPKLEFK.ESLHSLQQVLSGA.KED..HAIALAPKLFVR....HGSF....SnwSNQWWSTIIQHLQHPSSHVSQDStlrtiDSHILAVRR.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.49|      13|      15|    1595|    1607|       7
---------------------------------------------------------------------------
 1595- 1607 (23.53/13.70)	LPKRGGQGGTNKD
 1611- 1623 (19.96/10.36)	IDEDSSASGSNSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.71|      10|      15|     218|     227|       8
---------------------------------------------------------------------------
  218-  227 (19.25/10.45)	IPSNPIPLDR
  235-  244 (17.46/ 8.74)	LGSNEISAHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.42|      14|      24|    1150|    1163|      10
---------------------------------------------------------------------------
 1150- 1163 (24.11/17.30)	LAT..RINNGED...VIEA
 1172- 1190 (14.30/ 6.84)	LATldRAATADDtdlLCEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.09|      23|     142|     158|     181|      12
---------------------------------------------------------------------------
  158-  181 (37.82/29.95)	RLQfLNDLANPNVPLYKLMRTPVP
  306-  328 (40.27/26.25)	RVQ.LGQLALPNINAKSTVKPGVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.04|      13|      29|    1284|    1296|      14
---------------------------------------------------------------------------
 1284- 1296 (25.84/13.31)	LVLHHDISTPPQP
 1314- 1326 (24.21/11.99)	LVLDSNSPTTPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.37|      15|      21|    1076|    1090|      22
---------------------------------------------------------------------------
 1076- 1090 (26.67/18.78)	LKDTF.LSTEWSKPSS
 1098- 1113 (21.70/13.64)	MEDTLkLIMSEKQPNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09360 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPLPTRYPPGVNPYAPSTSSKTPRTGHRPHPPAKPPKALLDDVDI
2) NLANRWQDPASGTAAAEGGAEEEEQDEEEEGNLPWENYASERTLGDGMNESPFERQKSTLLFDNAEELSLADQNGIEEDEVEYPRSGSISASVGTVKRRMSTRSQSSPTKPLAHLPKRGGQGGTNKDPISIDEDSSASGSNSDSDDSTSSEEVLEVQKPAAKKPRTSSTSTGGKRPATAGKAPARKSVGGKSVARKNTGGKSTRGTGGKAPRGRRKSSLVD
3) SAHRSRTQPQHHQTASANPNTPVGVSPAAAATPSSTTTII
1
1481
241
45
1701
280










Molecular Recognition Features






MoRF SequenceStartStop




1) PATAGKAPARKSVGGKSVARKN
1656
1677