<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09355

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTDFLGGGPPRPTTVIPGRWIIELPSSNTQIYIHRFRQAGQSDQAGPYDYDIHDVALDPFERAWKKVNDNVNELAPISHSLEQPCAIISNERVNEKREKALWYFTTSNSEIDRPEGLEEITPPLQPISITQLVTCPKHGHESSCLDSSSSAEGRAPCNVSLDTSQDVARHLDLLASALAEKMAWKKGNRILMDEIHADTINHSLNLLKAAIRPISSTKLLLSLQPISPPSSSTSPTSPTPLRLLPLGLPALHISSSNPTSTQERHLSSTFDSALGHTWKTGRSEARTRSQISGETQSDWSVYWVPVTTPPSTKASQGIFTIWPTHLSQPYFNTGQLQTKKPVIRPIEVKSSDLLGVSIGLFNFLSTYKEPDPPQEIEEDEDEGDENMDAESTVITAEPEPVIDDGGGSDKSDLDDLFSEHSGSSTPMIPPDQILGGQLEIPLPIETPISVSTDQVDDPMGFMSTGVENRQLSRNATSTTNGLENPPKEEMVTEDDFAFFDSPSDQIAGDADIIEEHGADQDMIGGDQIGSDLLPNSTDIDAVAPGDHILSLDGNPPHNQSLEEEALDHLPQAQDAPPPFASIDTTLDHHDEEITHPQVLPPIPAIIIPDPILQPPSPIPMPSEWFTTDIIPPSFSPLPLLPLSDSPFPYSLPTPAPTPSSLNWDLVERLQPPKSSNLTYADDWKMDEEISEIDEEEMYTGPPTPESSYFSSDEEENTVVNDKKRLSESNGTEIQFSGIRCIASEWVYLLYDTVLDDDRAKALMRDWNPSWIKDLTILPPTSPAEVDNSEWYKGLDLTRFVKEMIGNKALREMFDWSDGQHRNQSATVTLRSGIEGLTLHMTDSKYRTLPQPQISAGYHNYTINLASPSLQYWTELGLQPHGGYKNVEAIILCEETFEARDKGKQLGLEMKRVWEELHLGTHNTAEVGGAIQGVITVPAAVFSESIANLMNQFQSNVIIYVLLPSITAISSSLLKSLFNISLSPLSSTVIQLVPQYALDPSHYREMAFEVYNRIAEPIKEINARSISDPYGLSQPSTSDDHITRQAFTLARAETPTPEFSMSWPLKSYDVLNNDRSIYCGYTYDEDLEVTLGFIMDDLGELFDWMVWKDPRGMRWDNRVERVWKWMKGRSEGWLINWKINVVRVGNIYGDELRAWRKISDSSRDSITLLTTDQAHAPHGNWEDDIPKPRGFANIPPSTMNDPNSQIIDLSLSAQITTIPSVRIPIDLCPPSSPNGPKEVDVVYPLTSFILTHPASANEKYHSRVYNVLSHHKKEDKRMEDDLGEGIYRIGCLISTRWGIEDGLAGILGMGMKGLGSLARG
Length1319
PositionKinase
OrganismKwoniella bestiolae CBS 10118
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.07
Grand average of hydropathy-0.452
Instability index55.10
Isoelectric point4.61
Molecular weight146487.08
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09355
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     449.65|      93|      94|     394|     486|       1
---------------------------------------------------------------------------
  214-  268 (51.19/18.42)	.....................................................................ISSTKLLLSLqPISPPSS........S.TSPTSPTPLR...LLPLGLPALHISSSNPTSTQERHL..SS
  279-  373 (91.73/38.98)	KTGRSEartrsqisgetqsdwsvywvPVTTPPSTKASQGIF.TIWPTH..LSQ.P........YFN.....TGQLQTKK.PVIRPIE........VkSSDLLGVSIGlfnFLSTYKE...............PD..PP
  394-  486 (160.28/73.75)	ITAEPE....................PVIDDGGGSDKSDLD.DLFSEHSGSST.P........MIPPDQILGGQLEIPL.PIETPIS........V.STDQVDDPMG...FMSTGVENRQLSRNATSTTNGLEN..PP
  491-  578 (108.16/47.31)	VT.EDD....................FAFFDS.PSDQIAGDaDIIEEH.GADQ.D........MIGGDQI.GSDL...L.PNSTDIDavapgdhiL.SLDG.NPP...........HNQSLEEEALDHLPQAQDapPP
  582-  634 (38.28/11.87)	.......................................ID.TTLDHHDEEIThPqvlppipaIIIPDPILQPPSPIPM.PSEW...........F.TTDII..PPS...F...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.32|      18|     207|    1083|    1100|       2
---------------------------------------------------------------------------
 1083- 1100 (31.36/21.41)	DEDLEVTLGFIMDDLGEL
 1299- 1316 (31.96/21.97)	EDGLAGILGMGMKGLGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.68|      27|     207|     637|     671|       3
---------------------------------------------------------------------------
   42-   74 (37.73/11.90)	SDqaGPYDYDIHDVALDPFERAWkkvnDNVNEL
  643-  669 (51.96/45.20)	SD..SPFPYSLPTPAPTPSSLNW....DLVERL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.00|      23|      24|     837|     859|       6
---------------------------------------------------------------------------
  837-  859 (42.99/29.38)	TLHMTDS..KYRTLPQPQISAGYHN
  861-  885 (39.01/25.83)	TINLASPslQYWTELGLQPHGGYKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.31|      39|     285|     747|     793|       8
---------------------------------------------------------------------------
  747-  793 (68.63/46.03)	YLLYDTVLDDD....RAKALMRDWNP......SWikdltilpPTSPAEVDNSE..WYKG
 1029- 1079 (56.68/26.45)	YGLSQPSTSDDhitrQAFTLARAETPtpefsmSW........PLKSYDVLNNDrsIYCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.01|      36|     247|     934|     970|      10
---------------------------------------------------------------------------
  934-  970 (55.53/38.27)	ITVPAAvFSESIANLMNQFQSNVIIYVLLPSITAISS
 1184- 1219 (64.48/40.56)	IPKPRG.FANIPPSTMNDPNSQIIDLSLSAQITTIPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.85|      22|    1274|       1|      22|      12
---------------------------------------------------------------------------
    1-   22 (45.29/27.75)	MTDFLGGGPPRPTTVIPGRWII
 1277- 1298 (43.55/26.37)	MEDDLGEGIYRIGCLISTRWGI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09355 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EISEIDEEEMYTGPPTPESSYFSSDEEENTVVNDKKRLS
2) YKEPDPPQEIEEDEDEGDENMDAESTVITAEPEPVIDDGGGSDKSDLDDLFSEHSGSSTPMIPPDQILGGQLEIPLPIETPISVSTDQVDDPMGFMSTGVENRQLSRNATSTTNGLENPPKEEMVTEDDFAFFDSPSDQIAGDADIIEEHGADQDMIGGDQIGSDLLPNSTDIDAVAPGDHILSLDGNPPHNQSLEEEALDHLPQAQDAPPPFASIDTTLDHHDEEITHPQVLP
688
367
726
600










Molecular Recognition Features






MoRF SequenceStartStop




NANANA