<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09350

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDIGDYGTNVVCTYELNSIAYSFFECPSDATSVSTELYKLVAQLQQLGLLAAKDNKKAGLWIFETGDNAEPASSPSGAAQLPSLASNLGIDLALKHSGSYDSNSLLESWKSLSKPPTNTISSPSTDSGEPLSQKESFEKHFRAAQAAIMNKEATVNNSLIGLNNDAGTINPTLKDRARQFQLLAQSRLRLHIHDYFLTAVFLSLGYALCLDHGYIPLSSRTLVVPKSNLATTGPQITAQSNNGKGEDRLQLVTLSSDYTGSKVLVIKATLTTSMSYIGCDLPRLVKHEDVPIPANATLILGPGGSTGNFKGLANNGFQSTVSKFATDSDEAQHSGNEGQPSSHRLRSRCLEWLVGKGINKERLENSAWFMVEIYLNQLTSNARQGLSEERVLIPWPSFLCFRQTDNTLSSNDAFGTLSIYDPLEFAQTWYAGQQDREATIIRRKKERDAAEAAAKSQADSEAQDLHSLYSPLALRRSSVAGLVYPTPPDGVQHTVGATPTFDEAVSTPGQQGLPLSTDASSSLVTKTEADANGPLDIASHADFDFQDTSNGNLFGDAGDDLFGEENDITDADFSFFDEPDIFQGNQDVEMPGQDNAPEVVENELTLGPKDDLNMGDVPDMADVHMGNTDESPVEESLPPDLPSDTDPARQIEIKTEASMEGPETSMDEPSPPLKPEYVFGRLSTFDVFSKPLLTKPQEDISSVVLNPAGAFGGVDFKALFASLHQKYGSHGRFIYPPPKVSPNTLRAKFPTTDYFNRRRRRKLAGKSSIVRGVHTGSDHHFLVPGQTINFEQPTQRGSRSPSPSSDQDDSSDEMDGSYSHNSSSLKRRQQLEDTSESNDDEEITSSFQELQVGQVDETNNAALDTVYPFALDSDFARWSAAMFLAWPNPWANEYTLTDAEYIAAAQILGDQAISYTLRYPNDGNRHTSSLEENIKATYTPDLIRQDVVQAAKKYFKGASPQTLSNFLDIQGVPRQLTGNNRLPPRPMPSSQGSQGSQGSNPTKPNPIFPLPSPHLQLRRSDSRLSVLPSALPFWDVLGLAPRGNGKHVTSLCVFPKAVGMAESADLFLENIRSAYETRRLGSHERLNTEGSVNGLLPIELGGQATRFASDQGLSVIREALFQVANLLASSAADSTNFVVYFVYDPESPDILVPICSAFHSMFEVYKLAMAGKTVSNELVLQLVPLNFVSARTHLVVLPPTDYTRLAMEVYDRCFDFQAGVASPSVAIEPPLPRTIDFKLTATPSASLLQENSCLQIAYAQSIDDRWITAAWSDNTGSEQMTASYCLGRQDAPLTRQFSDIAHEIWETTLDIIASKKVHWRIIIAKCGVMEAQDVRFWKGLSETERNAQISLTLLSVDTQPALQLLPPGLSIPASTLTSQSTFYTTPVSTPQPSSILSPDQSGGTPTATPTDGTGELKIEPDATLIDLTNQSYGAVLAHRVNNSNSPLEVRPTAISGYLIKRTGASSSDVPAVMEVNIVWTDINPRLAENPLREILAWYSGLATLARARGIVDPVKDTRPWHIAAAEKAVRLLYLLM
Length1536
PositionKinase
OrganismPseudogymnoascus verrucosus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.08
Grand average of hydropathy-0.349
Instability index45.45
Isoelectric point4.90
Molecular weight167451.96
Publications
PubMed=29295979

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09350
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     359.77|      58|     182|     485|     543|       1
---------------------------------------------------------------------------
  485-  542 (102.31/49.65)	PTPPDGVQHTVGATPTFDEAV..STPGQQGLPLSTDASSSLVTKTEADANGP...LDI...........ASHAD
  576-  622 (69.85/24.91)	FDEPDIFQ...G.....NQDV..EMPGQDNAPEVVENELTLGPKDDLNMG......DV...........PDMAD
  624-  667 (39.34/15.09)	.........HMGNTD..ESPVeeSLP..PDLPSDTDPARQIEIKTEASMEGPetsMD.................
  669-  732 (73.67/32.86)	PSPPLKPEYVFGRLSTFD.VF..SKP.LLTKP.QEDISS..VVLNPAGAFGG...VDFkalfaslhqkyGSHGR
 1372- 1422 (74.60/33.41)	PASTLTSQSTFYTTP.....V..STP.QPSSILSPDQSGGTPTATPTDGTGE...LKI...........EPDA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     480.52|     152|     542|     314|     477|       5
---------------------------------------------------------------------------
  314-  477 (237.43/171.20)	NNGFQSTVSKFATDSDEAQHSGNE....GQPSSHRLRSRCLEWLVGKGInkerLENSAWFMVEIYLNQltSNARQGLSEERVLIPW.PSFLcfRQtDNTLSSNDAFGTLSiydPLEFAQTWYAGQQDREATIIRRKKER..DAAEAAAKSQAD..SEAQDLHSLYSP.LALRRS
  859- 1020 (243.09/144.30)	NNAALDTVYPFALDSDFARWSAAMflawPNPWANEYTLTDAEYIAAAQI....LGDQAISYTLRYPND..GNRHTSSLEENIKATYtPDLI..RQ.DVVQAAKKYFKGAS...PQTLSNFLDIQGVPRQLTGNNRLPPRpmPSSQGSQGSQGSnpTKPNPIFPLPSPhLQLRRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.55|      19|     446|     736|     754|       6
---------------------------------------------------------------------------
  736-  754 (37.10/23.73)	PPPKVSPNTLRAKFPTTDY
 1184- 1202 (35.45/22.30)	PLNFVSARTHLVVLPPTDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09350 with Med13 domain of Kingdom Fungi
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