<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09346

Description RNA polymerase II mediator complex subunit
SequenceMSTRPPQPGPRPPQRSLSGTGMLQRQAQQRSHLQQSQQQPSPGRASDSSAVEVIADGAETAPPRLEPSKPGGSMVRVEGLMAQKQNIVSMESPSPAGTPGAVMPLPKRARQRIPFRRHEAQSDAPKQVGSPQKSSANLPLPMPARPGRSGVSHIQKKAHDGGNSPKKETRPKPYVLEPPPDAPSYPSNGHLDYFPWTGTHNEDSFNDNVIRQGYFDKVQTGQNETASAKQQLYPSLRQKNGLQTLGSLFAHVLGQRRQHSQITAAPSFKPPPRVTLTDTKRETWLRDLANPLIPLRRLSRTIPHGIKNKVLLEQCTRKNVPTERAVWLAKCVGANEIRASKRKGVPGALAMGGESKWIRDWTVCVEQFVDGVVAAGGDKDWKSKVLYSIRLSAHLYSEQLLDTEHYLDWLLSSLESTPLTRLPIWLLIAEVYWADILRYRKSARRVVAALCSNLQDAHESPDRDLLLPLIERVGNILTATVRTNPESFIALSHWPKYSDTLEACNTSGGPDETQIFDAISRRNARLKSRSSGGDETQNSRRRVIDLLDASLSVQFSPDLPRECWKGMRDRTLLVQTLFDWATSCARPSLMKTFVAARLMRTWSRHGIDVDESVLNYLTFRSNGPGVSGDAVYHLVSELARSGHFCVSKYIQWVIARGGLHGSQDVATDGPCVTRLLAELPVHDLPENLLRIRKTLLNRASFSVDNETETINNMSLAFERCSPNLYGKTPSGEEAPTTADVVQNITHLSRTVKAELGLQLRKQINLRMTKTSPSEMGEWKADQEYETATTVTVADFNFTRAVLEATEDLSMLADILKLVSSSSSIQILASIADTLNMHRLTFSAIGALNDLFDTLVSRQFSLGAIQGPESVALLHSLCALSGTIPDAANVHVQLSRDVARCVRRSAVDACSPVSDHVAEALQKSDGDISDEVDKLLSSGTSMDAPTLKRLFQVLINQMEASWAKSDSGLQKHGPILERLRTFDTKQFDNLLTPWVEQTILKSDRPNLSHVLGPLISAGCLSFKDVLKASVSSVQKTRDDSDKLMTSRIAFESLSLVLNTYRDGDIMSVEDAYTLNIRRTQAQFKDHLAILKIARNAIEISEPSIDNNDVTVNLLCQGDAFRRFLQRLVLTEFDCVLEEFVTPLAKSQDLHIITCLRAILRGLLDLKTTTTGPEDLVVARRIEVIFGVASDLTLPFCQLALRSLSASEAPSSSSEAAADTSRLEAYERAVDAALANNNPTWTKIIPTLDPQIAQHLCDRAERSLLSTIPSFKPPSSDSPAPPQPPSDPALAKRMLFVISATAYSTQNLGSNTTALDIGEKINNLAHALSQPPTTDTYSETTTWLPLMLEYITTHASTLPSSRPATDVRARVLLALSALLLALHAHTGTDALSEHVLDVSLLLVDELPDDARAQCGRFLSERGKEVVLGDPGLRYVFGLETGGGGGDGGGSGNGGTLMINQRGRMEGFVVRRWECLSEPTPLVGENDAALSLSLFQARR
Length1496
PositionKinase
OrganismPseudogymnoascus verrucosus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.05
Grand average of hydropathy-0.309
Instability index48.12
Isoelectric point7.38
Molecular weight164197.49
Publications
PubMed=29295979

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP09346
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.62|      37|      39|     793|     831|       1
---------------------------------------------------------------------------
  793-  831 (54.72/44.94)	ADFNFTRAVLEATEDLSMLADilKLVS...SSSSIQILASIA
  832-  871 (57.90/40.88)	DTLNMHRLTFSAIGALNDLFD..TLVSrqfSLGAIQGPESVA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.82|      36|      39|     935|     973|       2
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  935-  973 (57.47/41.34)	LSSGTSMDAPTLKRLfqvLINQMEASWAKSDSGLQKH..GP
  975- 1012 (59.36/34.93)	LERLRTFDTKQFDNL...LTPWVEQTILKSDRPNLSHvlGP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     154.07|      35|      39|     112|     146|       3
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    6-   41 (22.25/ 6.46)	........PQPGPRPP.qrslsGTGMlqrqaqqRSHLQQS........................QQQPS
   42-   98 (28.22/10.42)	PGRASDSSAVEVIADG...aetAPP.........RLEPSKpggsmvrveglmaqkqnivsmESPSPAGT
   99-  130 (53.51/27.19)	P...GAVMPLPKRARQ......RIPF.......RRHEAQS.....................DAPKQVGS
  131-  170 (50.09/24.92)	PQKSSANLPLPMPARPgrsgvsHIQK.......KAHDG.G.....................NSPKKETR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.89|      13|      25|     345|     357|       4
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  345-  357 (25.85/15.25)	VPGALAMGGESKW
  369-  381 (25.04/14.54)	VDGVVAAGGDKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.37|      15|      25|    1028|    1043|       6
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 1028- 1043 (21.66/17.67)	SVSSVQKTRDDSDkLM
 1051- 1065 (26.71/16.82)	SLSLVLNTYRDGD.IM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.40|      19|      25|     637|     660|       7
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  637-  660 (23.51/30.37)	ELARSGHfCVSKyiqwVIARGGLH
  664-  682 (33.89/20.60)	DVATDGP.CVTR....LLAELPVH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.37|      27|      38|    1097|    1124|      10
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 1097- 1124 (41.18/33.38)	EISEPSIDNNDVTVnLLCQGDAFRRFLQ
 1137- 1163 (44.18/30.48)	EFVTPLAKSQDLHI.ITCLRAILRGLLD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.07|      27|     281|     264|     326|      11
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  264-  295 (47.91/22.07)	AAPSFKPPPrvtltDTKRETW..LRD...LANPLIPL
  549-  580 (42.16/18.45)	ASLSVQFSP.....DLPRECWkgMRDrtlLVQTLFDW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.70|      31|     301|     297|     327|      12
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  297-  327 (57.88/36.85)	RLSRTIP.HGIK.NKVLLEQCT.RKNVP..TERAVW
  597-  632 (40.82/23.77)	RLMRTWSrHGIDvDESVLNYLTfRSNGPgvSGDAVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.03|      26|      26|    1370|    1395|      13
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 1342- 1364 (28.19/14.61)	...LPLMLEYITTHASTLPSSRPATD
 1370- 1395 (40.33/24.52)	LLALSALLLALHAHTGTDALSEHVLD
 1398- 1419 (27.51/14.05)	LLLVDELPDDARAQCGR.FLSER...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.90|      21|      32|    1258|    1278|      15
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 1258- 1278 (36.59/18.88)	AERSLL...STIPSFKPPSSDSPA
 1289- 1312 (30.30/14.45)	AKRMLFvisATAYSTQNLGSNTTA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.70|      21|      40|     719|     739|      18
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  698-  718 (29.11/13.87)	RASFSV.DNETETINNMSLAFE
  719-  739 (36.19/18.82)	RCSPNL.YGKTPSGEEAPTTAD
  760-  781 (30.40/14.77)	RKQINLrMTKTSPSEMGEWKAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09346 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FNDNVIRQGYFDKVQTGQNETASAKQQLYPSLR
2) MSTRPPQPGPRPPQRSLSGTGMLQRQAQQRSHLQQSQQQPSPGRASDSSAVEVIADGAETAPPRLEPSKPGGSMVRVEGLMAQKQNIVSMESPSPAGTPGAVMPLPKRARQRIPFRRHEAQSDAPKQVGSPQKSSANLPLPMPARPGRSGVSHIQKKAHDGGNSPKKETRPKPYVLEPPPDAPSYPSNGHLDYFPWTGTHNE
205
1
237
202










Molecular Recognition Features






MoRF SequenceStartStop




1) GAVMPLPKRARQRIPFRRHEA
2) HIQKKAH
3) LMAQK
100
153
80
120
159
84