<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09343

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMENGYGTGAHTNHDRDGAPNRPNGAVQASSRPAEKTGMPVHQQPPNQSVQLNGANGAPMTQSAGHPAGSVSKDANIQTKSTPPEINHITEGFESLPNLLARLAQVTHNQLSGKLLELAGMNIQQSPDNSNAVSFVSGPDDNSAENIKKKVNLLKFAEGVHSNWTKALVITQWSRIGEEVSRVIDLKAHLDEQKLYYDIAVHELSEVKRSLVHARLPNPDLRTAVEVLSTGKASWMPDLGYIEPPPLTAKEILQSLQNLNTLLSIRLNLHDYDKIPYHFRSYTIKSGRVTFRVEGEFEVDLTIADEDPEKQFWFIDFRFLFSPSPSALTDQMRFSLEAKVNTVLEKDGLAGCYKVLHDLTLTHKISELRRQAYEIGRSRWIDSLMVEPLRRSLSIQYWVDRYGKDGPKSWIIIGVVSGKKKGAYPDEKETSRIGIRWFRDSKEVRDVEIPLELTTLSVEGLLRSVITMHVSHILESMYKSLRTKPLYENRDLVLSFKKPTAAEQEPELHVQLTSQYKINVIVEYITGKFAISPSSRLTSQAEYRLNNQTVDPASNGHEYIENLHCVLISEDTVNRAYTVGWLPVRNPRLPQDELKPFLPRDTLQLSWFKKPGWDPNWYLALSSGMSGERWWLIEVTNVPDGPRPAADSIVLEGPTVRSHIQLPLKSVSPAPTYAFLSSLHLLSTSMISYYTNMRALHSRRAKFMLRNPSKSSLSSRQSQPALYVMLSTLLPSKNRSPRTGKPWAKDVLKVSFQGIETLEQKEAATSPAGGSSQSPSNPSTAPSGPIAPRQSEPEEGAIMIAEGHMETAIPAGLLVKQHVDKDIAFHPSTSAFAFRLQAKVGEPSITPLIERLQRVERLVDFVQVINAHPDSLHCESVSLSRLIFSYGCVQSPSPNQPKTESPRYQAIIDFSSQTTKLELQLEAGNPHIRILDHLTKILNSPLGLHGLATILPLTLPVLRALDAAEDSWEDIPSSELQILCRAADWYAVRYILTPPSEGDNKAPPPPKRIVFEIRLHRRGNVPWWCMRRDQKHNAATVDPLDLALKEKVWTGSEKGVWMGMQCAAIAQTGGAEAMVLRVDSAMRDLAKDGTVFANAAPGVTGVKGEGGAAEMTDVLGSQSGQMQAQVVNAPNKAQPQRPQTKSPVLQKQVQKKAQVPPTTQQQRTQAALNEAQHRAQYQAQQQARQKEMHRQAQIQARQGQGQQRPNPNNANGGNGNSGKQDAIVID
Length1230
PositionTail
OrganismPseudogymnoascus verrucosus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.06
Grand average of hydropathy-0.461
Instability index50.42
Isoelectric point8.78
Molecular weight136563.49
Publications
PubMed=29295979

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09343
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.86|      37|      37|    1133|    1169|       1
---------------------------------------------------------------------------
 1133- 1169 (63.98/39.95)	APNKAQPQRP.QTKSPVLQKQVQKKAQVPPTTQQQRTQ
 1171- 1208 (57.87/35.37)	ALNEAQHRAQyQAQQQARQKEMHRQAQIQARQGQGQQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.04|      12|      37|    1073|    1084|       3
---------------------------------------------------------------------------
 1073- 1084 (21.78/14.15)	GGAEAM..VLRVDS
 1110- 1123 (17.26/ 9.70)	GGAAEMtdVLGSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.64|      10|      37|     472|     483|       4
---------------------------------------------------------------------------
  472-  483 (14.83/17.50)	MHVShiLESMYK
  512-  521 (18.81/12.27)	LHVQ..LTSQYK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.45|      38|      42|     735|     773|       5
---------------------------------------------------------------------------
  735-  773 (61.05/35.91)	PSKNRSPRTGkPWAKDVLKVSFQGIETLEQKEAATSPAG
  779-  816 (67.40/36.14)	PSNPSTAPSG.PIAPRQSEPEEGAIMIAEGHMETAIPAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.14|      32|      37|      32|      63|       6
---------------------------------------------------------------------------
   32-   63 (57.21/34.49)	QASSRPA....EKTGMPVHQQPPNQSVQLNGANGAP
   66-  101 (47.44/27.27)	QSAGHPAgsvsKDANIQTKSTPPEINHITEGFESLP
  114-  134 (26.49/11.81)	QLSGKLL....ELAGMNI.QQSPDNS..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.27|      15|      37|     269|     283|       7
---------------------------------------------------------------------------
  269-  283 (29.05/17.86)	IRLNLHDYDK......IPYHF
  303-  323 (20.22/10.41)	VDLTIADEDPekqfwfIDFRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.06|      15|      15|     670|     684|       8
---------------------------------------------------------------------------
  670-  684 (26.62/15.90)	SVSPAPTYAFLSSLH
  687-  701 (27.45/16.62)	STSMISYYTNMRALH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.28|      37|     259|     363|     400|       9
---------------------------------------------------------------------------
  363-  400 (60.55/41.05)	LTLTHKISELRRQAYEI.....GRSRWIDSLMVE.PLRRSlSIQ
  623-  665 (56.73/33.96)	LALSSGMSGERWWLIEVtnvpdGPRPAADSIVLEgPTVRS.HIQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09343 with Med14 domain of Kingdom Fungi
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