<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09334

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLLMDDDMEVDIDDLFGDGAGGLLPPSRPPPKELFQRVDELRGSGCCQSIAWSRWGSIASITSNGLGLEFRNLRIHPKDGSWDLSDPTVIPQIAPTVDGGQLKHLCWSPNGADLAAIDSAGRIAILNLAQSLNKPTFTRNSNVDPIEDLRAVVGAYWLNLSPSNLRQPGIQSVAVKTSTDYRYEISQAIAFGPCFPNAHKSALITVSTNGVLSLLWPQADGKWHELSSDIEGISSSDDLITHASICADKNNTLLLAFATTAKKLSIARVAIKWGSPTANPADRPVNPALNTVTPTIIIRLLSDTNWMDGSTSDASDPFHLSPSMAALSHLSILSPSPDGPGGRPTSPTVITIRSHLPNPMSQYNQDTHSLINKWELSEASPSVHPAFEQLSARRNSVGSKPGPSPSLKKQEGFTSNKVVIWIEAIYFERIICFGYSDGSVEYRDRTSLAELFTQGGLDKFSHISQIGFTYNDYEPSLVGALSPTHLSVVQKGCDGKIKWNPLVYNMGEIGTSLEDTQYAAVIAGFNMACSTAIMNSSNHDDLMAAASKFKHLPSFAFDLVSEVSKTLKFNVDYSEESHHDSLIRNPSIQLSLSIQNALGYNGDAHKRTFESKIAWISLQLRNCVVLITMAMNIRVPIPDQQKKVLGLEDSEVIRLLAGSVRWCLDLMSWLIDCLLHPEDPEVFESVTKGEDGSIPLLSAHLLATNNIALHVLLSSVTRGFLTGICRRLAHLDYTARKAMSAAQSVSAPPGQSAPLISNSLRSSYTAIATLTSSSIVPISRFEAFVARIADVVKEAYTTAKFPSQQQAQGAPGDSKRNAVEQGILFGGALPEVMAPAISRIFTGELPKLRAEIDPSRLFFHDFGILGLPESNASAGKGVTEGSATTSSALYRVNYTIDIFSRVPIQLGMEPEEAQGLDPRGSRPGRRWRRCVRCAAAMEDIHSLTPPVQFLIMQQRRCYCGGNWDILAGARVVA
Length974
PositionTail
OrganismPseudogymnoascus sp. 05NY08
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.07
Grand average of hydropathy-0.116
Instability index46.96
Isoelectric point6.05
Molecular weight105753.93
Publications
PubMed=29295979

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09334
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.87|      15|      29|     688|     716|       1
---------------------------------------------------------------------------
  688-  702 (26.18/28.47)	TKGEDGSIPLLSAHL
  718-  732 (27.69/ 6.30)	TRGFLTGICRRLAHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     564.58|     190|     217|     115|     331|       2
---------------------------------------------------------------------------
  122-  331 (283.97/240.58)	GR...IAILNLAQSLNKPTFTRNsnvdpiEDLRAVVGAYWLN.LSPSnLRqPGI.QSVAVKTSTDYRYEISQAIAFGPCFPNAHKSALI.TVSTNGVLSLLWPQADGKWHELSSDIEGISSSD.DLITHAS....ICADKNNTLLLAFATTakKLSIARVA....IKWGSPTANPADrpVNPALNTVTPTIII...RLLSDTNWMDGSTSDasdpfHLspsMAALS...HL
  343-  553 (280.61/177.13)	GRptsPTVITIRSHLPNPMSQYN......QDTHSLINKWELSeASPS.VH.PAFeQLSARRNSVGSKPGPSPSLKKQEGFTSNKVVIWIeAIYFERIICFGYSDGSVEYRDRTSLAELFTQGGlDKFSHISqigfTYNDYEPSLVGALSPT..HLSVVQKGcdgkIKWNPLVYNMGE..IGTSLEDTQYAAVIagfNMACSTAIMNSSNHD.....DL...MAAASkfkHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.14|      18|      29|     574|     591|       3
---------------------------------------------------------------------------
  574-  591 (32.64/22.82)	YSEESHH...DSLIRNPSIQL
  601-  621 (27.51/18.01)	YNGDAHKrtfESKIAWISLQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09334 with Med16 domain of Kingdom Fungi
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