<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09326

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGYGTGAHTNHDRDGAPNGTNGALQASSRAAEKSGMSGHQQPPNQSVQMSGANGAPMTQSADHPAGSVSNDTNIQTKSTPPEITHITDGFESLPNLLTRLAQVTHNQLSGKLLELAGMNIQQSPDNSNAVSFVSGPDDNSAENIKKKVNLLKFAEGVHSNWTKALVITQWSRISEEVSRVIDLKAHLDEQKLYYDLAVHELSEVKRSLVHARLPNPDLRTAVEVLSTGKASWMPDLGYIEPPPLTAKEILQSLQNLNTLLSIRLNLHDYDKIPYHFRNYTIKSGRVTFRVEGEFEVDLTIADEDPEKQFWFIDFRFLFSPSPSTLTDQMRFSLEAKVNTVLEKDGLAGCYKVLHDLALTHKISELRRQAYEIGRSRWIDSLMVEPLRRSLSIQYWVDRYGKDGPKSWIIIGVVSGKKKGAYPDEKETSRIGIRWFRDSKEVKDVEIPLELTTLSVEGLLRSVITMHVSHILESMYKSLRTKPLYQNRDLVLSFKKPTAAEQEPELHVQLTSQYKINVIVEYITGKFAISPSSRLTSQAEYRLNNQTVDPASNGHEYIENLHCVLISEDTVNRAYTVGWLPVRNPRLPQDELKPFLPRDTLQLSWFKKPGWDPNWYLALSSGMSGERWWLIEIANVPEGPRPAPDSIVLDGPTVRSHIQLPLKSVSPAPTYAFLSSLHLLSTSMISYYTNMRALHSRRSKFMLRNPSKSTLSSRQGQPALYVMLSTLLPSKNRSPRTGKPWAKDVLKVSFQKIETLEQKEPAASPAGGSSQSPSNPPTAPSGPVGPRQSDTEEGAIMIAEGHMETAIPAGLLVKQHVDKDIAFHPSTSAFAFRLQARVGEPTITPLIERLQRVERLVDFVQVINAHPDSLHCESVSLSRLIFSYGCVQSPSPNQPHTESPRYQAIIDFSSQTTKLELQLEAGNPHIRILDHLTKILNSPLGLHGLATILPLTLPVLRALDAAEDSWEDIPSSELQILCRAADWYAVRYILTPPSDGDNKAPSAPKLIVFEIRLHRRGNVPWWCMRRDQKHNPATVDPLDLALKDKVWTGSEKGVWMGMQCAAIAQTGGAEAMVLRVDSAMRDLAKDGTVFASAAPGAIGVKGEGAVGEMTDGLGGQIGMAQAQAQAVNAPNKAQPQRPQTKSPVLQKQVQKKAQGPPTQQQRTQAALNEAQHRAQYQAQQLARQKEMHRQAQVQARQGQGQQRPNANNANGGNGNSGNQDAIVID
Length1226
PositionTail
OrganismPseudogymnoascus sp. 05NY08
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.06
Grand average of hydropathy-0.458
Instability index48.19
Isoelectric point8.46
Molecular weight135848.41
Publications
PubMed=29295979

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP09326
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     251.11|      90|     114|     483|     577|       1
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  483-  513 (26.98/ 9.52)	.....................................................................................................................KPLYQNRDLVLS.FKKPTAAEQ.EPELHVQLTS
  514-  622 (121.69/98.00)	QYKINVIVEYITGKFAiSPSSRL....TSQAEYRLNNQTVDPASnGHEYIENLHcvLISEDTVNRaYT.................................vgwlpvrnprlpqdelKPFLPRDTLQLSwFKKPG...W.DPNWYLALSS
  628-  762 (102.44/64.59)	RWWLIEIANVPEGPRP.APDSIVldgpTVRSHIQLPLKSVSPAP.TYAFLSSLH..LLSTSMISY.YTnmralhsrrskfmlrnpskstlssrqgqpalyvmlstllpsknrsprtgKP.WAKDVLKVS.FQKIETLEQkEP........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.93|      15|      20|     698|     717|       2
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  702-  717 (24.15/20.99)	FMLRN..PSKSTlSSRQG
  723-  739 (23.79/ 6.80)	VMLSTllPSKNR.SPRTG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     799.06|     283|     741|       6|     312|       3
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    6-  204 (236.55/158.70)	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................G.....................TGAHTNHDRDGAPNGT......NGALQASSRAA..EKS.GMSGHqQPPNQSVQMSGANGAPMTQSAD.....HP.AGSVSNDTNIQTKST.PPEITHITDGfeSLPNLLTRLAQVTHNQLS..GKLLELAGMNI.....QQSPD..NSNAVSF.........VSGPDDNSAENIKKKVN.LLKFaegvhSNWTKALVItQWSRISEEVsRVIDlkaHLdEQKLYYDLAVHELS
  205-  312 (64.58/53.00)	EVKRSLVHARLPNPDL.RTAVEVLSTGkASWMPdLGYIEPPPLTAKEILQSLQNLnTLLSIRlnLHDYDKIPYHFRNYTIKSGRVTfrVEgefEVDLTIADE...DPEKQFW......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  768-  947 (202.89/105.90)	................................................................................................................fidfrflfspspstltdqmrfsleakvntvlekdglagcykvlhdlalthkiselrrqayeigrsrwidslmveplrrslsiqywvdrygkdgpkswiiigvvsgkkkgaypdeketsrigirwfrdskevkdveiplelttlsvegllrsvitmhvshilesmykslrtkplyqnrdlvlsfkkptaaeqepelhvqltsqykinviveyitgkfaispssrltsqaeyrlnnqtvdpasngheyienlhcvlisedtvnraytvgwlpvrnprlpqdelkpflprdtlqlswfkkpgwdpnwylalssgmsgerwwlieianvpegprpapdsivldgptvrshiqlplksvspaptyaflsslhllstsmisyytnmralhsrrskfmlrnpskstlssrqgqpalyvmlstllpsknrsprtgkpwakdvlkvsfqkietleqkepaaspaG.....................GSSQSPSNPPTAPSGP......VGPRQSDTEEG..AIM.IAEGH.......METAIPAGLLVKQHVDkdiafHP.STSAFA.FRLQARVG.EPTIT..........PLIERLQRVE........RLVDFVQV.I.....NAHPDslHCESVSLsrlifsygcVQSPSPNQPHTESPRYQaIIDF.....SSQTTKLEL.QLEAGNPHI.RILD...HL.TKILNSPLGLHGLA
  955- 1217 (295.05/158.37)	PVLRALDAAEDSWEDIpSSELQILCRA.ADWYA.VRYILTPPSDGDNKAPSAPKL.IVFEIR..LHRRGNVPWWCMRRDQKHNPAT..VD...PLDLALKDKvwtGSEKGVW........................................................................................................................................................................................................................................................................................................................................................................................................................................................................mgmqcaaiaqtggaeamvlrvDSAM....RDLAKDGTvfasaaPGAIGVKGEGAvgEMTdGLGG..QIGMAQAQAQAVN.APNKAQPQ.....RPqTKSPVLQKQVQKKAQgPPTQQQRTQA..ALNEAQHR.AQYQAQQLArqKEMHRQAQVQArqgqgQQRPN..ANNA.............NGGNGNS...............................................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09326 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LEQKEPAASPAGGSSQSPSNPPTAPSGPVGPRQSDTEEGAIMIAE
2) MENGYGTGAHTNHDRDGAPNGTNGALQASSRAAEKSGMSGHQQPPNQSVQMSGANGAPMTQSADHPAGSVSNDTNIQTKSTPPEITHITDGFE
3) VKGEGAVGEMTDGLGGQIGMAQAQAQAVNAPNKAQPQRPQTKSPVLQKQVQKKAQGPPTQQQRTQAALNEAQHRAQYQAQQLARQKEMHRQAQVQARQGQGQQRPNANNANGGNGNSGNQDAIVID
757
1
1101
801
93
1226










Molecular Recognition Features






MoRF SequenceStartStop




NANANA