<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09324

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDIGDYGTNVVCTYELNSIAYSYFECPSDPASVSTELYKLVAGLQQFGLLAAKDNKKAGLWIFETGDNAEPASSPSGGAQLSGLASNLGIDLTLKHSGSYDSNALLESWKSLSKPPTNTISSPLADSGEPLSQKESFEKHFRAAQAAIMNKEANVNNSLIGLNNDAGTLNPSLKDRARQFQLLAQSRLRLHIHDYFLTAVFLSLGYALCLDHGYIPLSSRTLVVPKSNLATTGPQTTAQGNNGHIDNHLQLVSLSSDYTGSKVLVIKATLSTSTSYTTCDLPRLVRHEDVPIPANATLILGPGGSTGNYKGLANNGFQSTVSTYATDADEAQHAGNEGQSSTSHRLRSRCLEWLVGKGINRERLENSAWFMVEIYLNQLTNNARQGSSEERVLIPWPSFLCFWQTDNTLNANDAFGTLSTYDPLEFAQTWYSGQQDRDATIIRRKKEREAAEAVVKAQADSEAQDLHSLYSPLALRRSSVAGLVYPTPPDGVQHTVGATPTFDEAVSTPGQQGLPLSTDASSSLVAKPEADANGPLDIASHADFDFQDTSNGNLFGDAGDDLFGEENDITDADFSFFDEPDIFQRNQDVEMPGQDNTTEVVENELTLGPKDDLNMGDVPEMADVHMGNTDESPVEESLPPDLPSDTNPAGQIEIKTEAGLEGPETSTDEPSPPLKPEYVFGRLSTFDVFSKPLLTKPQEDTSAVVLNPAGAFGGVDFKALFASLHQKYGTHGRFIYPPPKVSPNTFRAKFPTTDYFNRRRRRKLAGKSSIVRGVHTGADHHFIVPGQAIGFEQPAQQGSRSASPSSDQDDSSDEMDGSYSHNSSSLKRRHQVEDNSESNDDEEITSSFQELQVGQVDETSNAALDTVYPFALDSDFARWSAAMFLAWPNPWANEYTLTDAEYIAAAQILGDQAISYTLRYPNDGNRHSVSLEENNKATYTPDLIRQDVVQAAKKYFKGANPQTLSNFLDIQGVPRQLAGINRLPPRPGPSSQGSQGGQGSNPPKPNPIFPLPSPHLQLRRSDSRLSVLPSALPFWDVLGLAPRGNGKHVTSLCVFPKAVGMAESADLFLENIRSAYETRRLGSHERLNTEVCVNGLLPIELGGQATRFASDQGLSVIREALFQVANLLASSPADSTNFVVYFVYDPESPDILVPICSAFHSMFEVYKTAMVGKTTSNELVLQLVPLSFVSARTHLVVLPSADYTRLAMEVYDRCFDFQSGVASPSVAIEPPLPRTIDFKLTVNPSASLLQENSCLQIAYAQSIDDRWITAAWSDNTGSEQMTASYCLGRQDAPLTRQFSDIAHEIWETTLDIIASKKVHWRIIIAKCGVMEAQDVRFWKGLSETERNAQISLTLLSVDTQPALQLLPPSLSIPASTLAAQSTFYTTPVSTPQPASILSPDQSGGTPTATPTDGTGELKIEPDATLIDLTNQTYGAVLAHRVNNSNSPLEVRPTAISGFLIKRTGASSSDVPAVMEVNIVWTDINPRLTENPLKEILAWYSGLATLARARGIVDPVKDTRPWHIAAAEKAVRLLYLLM
Length1537
PositionKinase
OrganismPseudogymnoascus sp. 05NY08
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.08
Grand average of hydropathy-0.341
Instability index43.76
Isoelectric point4.89
Molecular weight167246.40
Publications
PubMed=29295979

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09324
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     381.52|     117|     300|     215|     346|       1
---------------------------------------------------------------------------
  215-  346 (173.41/131.15)	IPLS..SRTLVVPKSNLATTGPQTTAQGNNGHIDNHLQLVS...LSSDYTGSKVLVIKATLSTSTSYTTCDLPRLV.RHEDVPIPA..NAT......LILGPggstgnYKGLaNNGfqsTVSTYAtDAdeaqHAGNEGQSSTSHRL
  514-  638 (167.68/94.63)	LPLStdASSSLVAKPEADANGPLDIA....SHADFDFQDTSngnLFGD.AGDDLFGEENDI.TDADFSFFDEPDIFqRNQDVEMPGqdNTTevveneLTLGP......KDDL.NMG...DVPEMA.DV....HMGNTDESPVEESL
  655-  702 (40.43/12.98)	.............KTEAGLEGPETSTDEPSPPLKPEYVFGR...LSTFDVFSKPLLTKPQEDTS..................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.82|      17|     613|     384|     404|       2
---------------------------------------------------------------------------
  385-  404 (28.61/20.78)	QGSSEERVLipwPSFLCFWQ
 1020- 1036 (30.22/ 9.73)	RSDSRLSVL...PSALPFWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.62|      19|     672|     423|     472|       6
---------------------------------------------------------------------------
  423-  445 (31.02/57.05)	PLEFAQTWYSGQqdrdATIIRRK
 1491- 1509 (34.60/ 6.83)	PLKEILAWYSGL....ATLARAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.35|      18|     901|     481|     501|       8
---------------------------------------------------------------------------
  481-  501 (29.86/27.60)	AGLVYPTPPDGvqhTVGATPT
 1394- 1411 (33.48/20.94)	ASILSPDQSGG...TPTATPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09324 with Med13 domain of Kingdom Fungi
Unable to open file!