<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09320

Description Uncharacterized protein
SequenceMSTRPPQPGPRPPQRSLSGTGMLQRQAQQRSHLQQSQQPSPGRTSESAVDVIADGAETAPGRLEPSKPGGSMVRVEGLTAQKQNIVSMESPSQAGTPGAVMPLPKRARQRVPFRRHEAQSDAPRQVGSPQKSSANLPLPMPARPGRSGISHIRKKAHDGGNSPKKETRPKPYVLEAPPDAPSYPSNGHLDYFPWTGTHNEDSFNDNVIRQGYFDKIQTGQNETASAKQQLYPLLRQKNGLQTLGSLFAHVLGQRRQHSQITAAPSFKPPPRVTLTDTKRETWLRDLANPLIPLRRLSRTIPHGIKNKVLLEQCTRKNVPTERAVWLAKCVGANEIRASKRKGVPGALAMGGESKWIRDWTVCVEQFVDGVVTAGGDKDWKSKVLYSIRLSAHLYSEQLLDTEHYLDWLLSSLESTPLTRLPIWLLIAEVYWADILRYRKSARRLVAALCSNLQDAHESPDRDLLLPLIERVGNILTATVRTNPESFIALSHWPKYSDTLEACNTSGGPDETQIFDAISRRNARLKSRSSGGGETQNSRRRVIDLLDASLSVQFSPDLSRECWKGMRDRTLLVQTLFDWATSCARPSLIKTFIAARLMRTWSRHGIDVDESVLNCLTFRSNGPGVSGDAVYHLVSELARSGHFSVSKYIQWVIARGGLHGSQDVAADGPCVTRLLAELPVHDLPENLLRIRKTLLNRASFSVDDETETINNMSLAFERCSPNLYGKTPSVEEAPTTADVVQNITHLSRTVKAELGLRLRKQINIRMTKASPSEMGEWKADPEYETATTVTVADFNFARAVLEATEDLSMLADILKLVSSSSSTQILASIADTLNMHRLTFSAIGALNDLFDTLVSRQCSLGAIQGPESVVLLHSLCALSATIPDAANVHVQLSRDVARSVRRSAVDACSPVSDHVAEALQKSDGDISDEVDKLLSSGTSMDAPTLKRLFQVLINQMEASWAKSDSGLQKHGPILERLRTFDTKQFDNLLTPWVEQTILKSDRPNLSHVLGPLISAGCLSFKDVLKASVSNVQKTRDDGDKATTSRIAFESLSLVLNTYRSGGIMSVEDAYTLNIKRTQAQFKDHLAILKIARTVIEISEPAFDNNDVTVNLLCQGDAFRRFLQRLILTEFDCVLNEFVTPLAKSQDMHIITCLRAILRGLLDLKTTTTGPEDLVVARRIEVIFGVASDLTLPFCQLALRSLSASETPGSSSEATAADTSRLEAYERAVDAALANNNPTWTKIIPTLDPQIAQHLCDRAERSLLDTIPTFKPPSSSEFPALPKPSSDPALAKRMLFVIAATAYSTQNLAHTTALEIGEKINNLAHALSLPDSSSAIYSETTTWLPLMLEYITIHASTLPSSRPATDVRARVLLALSALLLALHAHTGTDALSEHVLDVSLLLVDELPDDARAQCGRFLAERGKEVVLGDPGLRYVFGLETGGGAGDGAGAGAGGGGSGTGGTLMINQRGKMEGFVVRRWECLSEPTPLVGENDAALSLSLFQARR
Length1503
PositionKinase
OrganismPseudogymnoascus sp. 05NY08
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.05
Grand average of hydropathy-0.265
Instability index46.86
Isoelectric point8.21
Molecular weight164419.01
Publications
PubMed=29295979

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP09320
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     595.33|     137|     174|     912|    1048|       1
---------------------------------------------------------------------------
  572-  649 (80.80/39.91)	..................................VQTLFDWATSCARP.SLIKT....F..IAARLMRTWSR..H..GIDVDESVLNCL.TF....................RSN.GPGVSgdavyHLVSELARS..GHFSVSK.....Y.IQ.............................
  652-  794 (135.13/71.71)	..IA............R.GgLHGSQ.DVAADgpcVTRLLAELPVHDLPeNLLRI....RKTLLNR..ASFSVDDEteTINNMSLAFER.......CSPNLYgkTPSVEEAPTTADvVQNIT.....H.LSRTVKAelG.LRLRKqinirM.TKA.SPSEMGEWKADPEyeTATTVTV.AdFN
  912- 1048 (226.15/124.99)	DHVA............E.A.LQKSDGDISDE...VDKLLSSGTSMDAP.TLKRL....FQVLINQMEASWAKSDS..GLQKHGPILERLRTFDTKQFDNLL..TPWVEQTILKSD.RPNLS.....HVLGPLISA..GCLSFKD.....V.LKA.SVSNVQKTRDDGD..KATTSRI.A.FE
 1082- 1224 (153.26/82.32)	DHLAilkiartvieisEpA.FDNNDVTV........NLLCQGDAFR.R.FLQRLilteFDCVLNEFVTPLAKSQ.....DMH..IITCLRAILRGLLD.LK..TTTTGPEDLVVA.R.RIE.....VIFG.VASD..LTLPFCQ.....LaLRSlSASETPGSSSEAT..AADTSRLeA.YE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.07|      49|      51|      19|      67|       3
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   19-   67 (78.90/41.34)	GTGMLQRQ..AQQRS..HLQQSQQPSPGRTSESAVDVIA.DGAETAPGRLEPSK
   69-  119 (69.26/35.39)	GGSMVRVEglTAQKQ..NIVSMESPSQAGTPGAVMPLPK.RARQRVPFRRHEAQ
  121-  169 (52.91/25.29)	DAP...RQvgSPQKSsaNLPLPMPARPGRSGISHIRKKAhDGGNSPKKETRP..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.19|      23|      28|    1309|    1333|       5
---------------------------------------------------------------------------
 1309- 1333 (34.50/26.67)	TTALEIG.EKINnlAHALSLPDSSSA
 1339- 1362 (39.69/24.20)	TTWLPLMlEYIT..IHASTLPSSRPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.96|      13|      22|     343|     355|       6
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  343-  355 (25.25/16.55)	VPGALAMGGESKW
  367-  379 (24.71/16.02)	VDGVVTAGGDKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.54|      15|      20|    1363|    1377|       9
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 1363- 1377 (22.73/12.23)	TDVRARVLLALSALL
 1386- 1400 (23.81/13.13)	TDALSEHVLDVSLLL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.45|      13|      29|    1225|    1238|      11
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 1225- 1238 (19.90/17.15)	RAvDAALANNNPTW
 1256- 1268 (22.56/13.97)	RA.ERSLLDTIPTF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09320 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSTRPPQPGPRPPQRSLSGTGMLQRQAQQRSHLQQSQQPSPGRTSESAVDVIADGAETAPGRLEPSKPGGSMVRVEGLTAQKQNIVSMESPSQAGTPGAVMPLPKRARQRVPFRRHEAQSDAPRQVGSPQKSSANLPLPMPARPGRSGISHIRKKAHDGGNSPKKETRPKPYVLEAPPDAPSYPSNGHLDYFPWTG
1
196










Molecular Recognition Features






MoRF SequenceStartStop




1) GAVMPLPKRARQRVPFRRH
2) ISHIRKKAHD
98
149
116
158