<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09319
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGIPDNFPMSLRPWPTKEAYGSALPTLISRINAERGQFRNLTEEDLLEEIAKGENEAAADNEDMSTEDETEAAPDRQKEVMDAKAEMLAQLEQAHHASMIALDFVALLLSKDQPVQAGLSISDGLRQVVSLGTLGADRVKDTRLTEPRKKDIAAVGKGWKIQSFNTSVESILNAASRLETEIAAETKYWEAILSVDEKGWKTCKLPQEQHTLGVRFGFFDAAPAFSNRSLAALRRQPDGTAYLDHGAADPTPKRVLIHIETNGVLTGALAPETSAPDSSPLEALVLRSRNAVFEEELWQELNREARTLANHSVRMTGDEISCQLTPSTRILLRLEPLSTSPPTTTPEPRAHDDIATMLSLALHLELSYAHRQNQHRRTQPPPPISSAPRPNAPYALLRPLLAYEHHIGVLAALRATTISLTTTLCAASLTVAPAILVPATPTPATSTEERVAALLSSREAEFLVPLPANQSVTIKLRSDLGIQTRFRVEITPALAAVCRAPPNPSVEEVRTFLWWAAGCAVVRAVVEKGEEGGVGEGLKGWKETASPCLVRKEEGGRSREIGVVVVEGRLEFKVKSGKGSKVMVWGVSGEERGVWEVVEKVGRSDGTEGAWGDGHEVIREVTEIE |
Length | 626 |
Position | Head |
Organism | Pseudogymnoascus sp. 05NY08 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes>
Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus>
unclassified Pseudogymnoascus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.284 |
Instability index | 48.65 |
Isoelectric point | 5.39 |
Molecular weight | 68138.42 |
Publications | PubMed=29295979
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP09319
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.57| 20| 38| 342| 372| 1
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342- 361 (36.32/11.18) PPTTTPEPRAHDDIATMLSL
382- 401 (35.25/24.13) PPPISSAPRPNAPYALLRPL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.24| 19| 24| 568| 590| 2
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568- 587 (30.96/30.40) E.GRLEFKVKSGK..GSKvMVWG
592- 613 (27.27/12.27) ErGVWEVVEKVGRsdGTE.GAWG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.51| 31| 38| 129| 161| 3
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129- 161 (47.78/37.58) VVSLgtLGADRVKDTRLTEPRK..KDIAAVG.KGWK
169- 202 (39.73/24.26) VESI..LNAASRLETEIAAETKywEAILSVDeKGWK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 99.30| 26| 26| 241| 266| 4
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218- 244 (29.12/14.37) ..GFFDAAPafsNRSLAALRRQPDGTAYL
245- 270 (42.89/24.36) DHGAADPTP...KRVLIHIETNGVLTGAL
273- 294 (27.29/13.04) ETSAPDSSP...LEALVLRSRNAVF....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 75.25| 23| 24| 417| 439| 5
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417- 435 (24.04/11.66) ..........TTISLTTTLCAAS...LTVAPA
436- 461 (28.00/14.69) ILVP...atpTPATSTEERVAAL...LSSREA
463- 494 (23.21/11.02) FLVPlpanqsVTIKLRSDLGIQTrfrVEITPA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 73.07| 23| 26| 497| 522| 7
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500- 522 (45.28/31.06) RAPPNPSVE.EVRTFL..W..WAAGCAV
524- 551 (27.79/ 9.67) RAVVEKGEEgGVGEGLkgWkeTASPCLV
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