<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09319

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSGIPDNFPMSLRPWPTKEAYGSALPTLISRINAERGQFRNLTEEDLLEEIAKGENEAAADNEDMSTEDETEAAPDRQKEVMDAKAEMLAQLEQAHHASMIALDFVALLLSKDQPVQAGLSISDGLRQVVSLGTLGADRVKDTRLTEPRKKDIAAVGKGWKIQSFNTSVESILNAASRLETEIAAETKYWEAILSVDEKGWKTCKLPQEQHTLGVRFGFFDAAPAFSNRSLAALRRQPDGTAYLDHGAADPTPKRVLIHIETNGVLTGALAPETSAPDSSPLEALVLRSRNAVFEEELWQELNREARTLANHSVRMTGDEISCQLTPSTRILLRLEPLSTSPPTTTPEPRAHDDIATMLSLALHLELSYAHRQNQHRRTQPPPPISSAPRPNAPYALLRPLLAYEHHIGVLAALRATTISLTTTLCAASLTVAPAILVPATPTPATSTEERVAALLSSREAEFLVPLPANQSVTIKLRSDLGIQTRFRVEITPALAAVCRAPPNPSVEEVRTFLWWAAGCAVVRAVVEKGEEGGVGEGLKGWKETASPCLVRKEEGGRSREIGVVVVEGRLEFKVKSGKGSKVMVWGVSGEERGVWEVVEKVGRSDGTEGAWGDGHEVIREVTEIE
Length626
PositionHead
OrganismPseudogymnoascus sp. 05NY08
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.05
Grand average of hydropathy-0.284
Instability index48.65
Isoelectric point5.39
Molecular weight68138.42
Publications
PubMed=29295979

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09319
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.57|      20|      38|     342|     372|       1
---------------------------------------------------------------------------
  342-  361 (36.32/11.18)	PPTTTPEPRAHDDIATMLSL
  382-  401 (35.25/24.13)	PPPISSAPRPNAPYALLRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.24|      19|      24|     568|     590|       2
---------------------------------------------------------------------------
  568-  587 (30.96/30.40)	E.GRLEFKVKSGK..GSKvMVWG
  592-  613 (27.27/12.27)	ErGVWEVVEKVGRsdGTE.GAWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.51|      31|      38|     129|     161|       3
---------------------------------------------------------------------------
  129-  161 (47.78/37.58)	VVSLgtLGADRVKDTRLTEPRK..KDIAAVG.KGWK
  169-  202 (39.73/24.26)	VESI..LNAASRLETEIAAETKywEAILSVDeKGWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.30|      26|      26|     241|     266|       4
---------------------------------------------------------------------------
  218-  244 (29.12/14.37)	..GFFDAAPafsNRSLAALRRQPDGTAYL
  245-  270 (42.89/24.36)	DHGAADPTP...KRVLIHIETNGVLTGAL
  273-  294 (27.29/13.04)	ETSAPDSSP...LEALVLRSRNAVF....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.25|      23|      24|     417|     439|       5
---------------------------------------------------------------------------
  417-  435 (24.04/11.66)	..........TTISLTTTLCAAS...LTVAPA
  436-  461 (28.00/14.69)	ILVP...atpTPATSTEERVAAL...LSSREA
  463-  494 (23.21/11.02)	FLVPlpanqsVTIKLRSDLGIQTrfrVEITPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.07|      23|      26|     497|     522|       7
---------------------------------------------------------------------------
  500-  522 (45.28/31.06)	RAPPNPSVE.EVRTFL..W..WAAGCAV
  524-  551 (27.79/ 9.67)	RAVVEKGEEgGVGEGLkgWkeTASPCLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09319 with Med17 domain of Kingdom Fungi
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