<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09318
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKTLDAQFLRVEKALATLVASISTYNPNPVLAHDLVAADQELSHGLADLATHQANYARIQSLKNTSSDLDAQIKGSLQLLSSTRSELLSTPATTFPSTTTPVSYTDLLSYARRISKFTLPPTYREAQPTPEPEGTGTQTNGTVTPTAPSNGAVVNAAELPVTPIQADTDKTSLPPIIAEWLNPHASAPGFVPWPTEETIRRGALASIQVLIDQGEDPATFDPERSAELEAERKRLEEEGERAKEEQQEAERAKQEQRMREEYARREAMGAAGQKVEEKPKVFTGLDLLDDMDDDDE |
Length | 297 |
Position | Middle |
Organism | Pseudogymnoascus sp. 05NY08 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes>
Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus>
unclassified Pseudogymnoascus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.626 |
Instability index | 42.56 |
Isoelectric point | 4.61 |
Molecular weight | 32495.59 |
Publications | PubMed=29295979
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP09318
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 89.72| 30| 61| 93| 133| 1
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93- 133 (46.89/46.16) ATTFPstTTPV.SYTDllsyarrisKFTLPPTYRE.AQPT.......PEP
157- 195 (42.83/22.31) AAELP..VTPIqADTD.........KTSLPPIIAEwLNPHasapgfvPWP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.52| 14| 15| 239| 253| 2
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239- 253 (18.63/14.29) EgERAKEE..QQEAERA
256- 271 (18.89/ 9.17) E.QRMREEyaRREAMGA
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