<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09316

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDDDMEVDIDDLFGDGAGGLLPPARPLPKELFQRVDELRGSGCCQSIAWSRWGSIASITSNGLGLEFRNLRIHPKDGSWDLSDPTIIPQITPTVDVGQLKHLCWSPNGADLAAIDAAGRISILNLAQSLNKPTFTRNGNVDPTDDLHAVVGAYWLNLSPSNLRQPGIQSVAVKTSTDYRYEISQAIAFGPCFPNAHKSALITVGTNGVLSLLWPQADGKWHELSSDIEGISTSDELITHASICADKNNTLLLAFATTAKKLSIARVAIKWGSPAANPPDRPVNPALNVVTPTIIIRLLADTNWMDGSASDASDPFHLSPSMAALSHLSILSPSPDGPGGRPTLPTVITIRSHLPNSLSQYNQDTHSLINRWELSEASPSVHPAFEQLSARRNSVGSRPGPSPSLKKQEGFTFNKVVIWIEAINFERIICFAYSDGSVEYRDRTSLAELFTQGGLDKFSHITQIGFTYNGYEPSLVGALSPTHLSVVQKGCDGKIKWNPLVYNMGDIGTSLQDTQYEAVIAGFNMACSTAIMNSGNHDDLMAAASKFKHLPSFAFDLVSEVSKTLKFNVDYSEESHHDSLIRNPSIQISLSIQNALGYNGDAHKRTFESKIAWISLQLRNCVVLITMAMNIRVPIPDQQKKVLGLEDSEVIRLLAGSVRWCLDLMSWLVDCLLHPEDPEVFESVIKGEDGSIPLLSAHLLATNNIALHVLLSSATRGFLTGICRRLAHLDYTARKAMSATHSASAPPGQSAPLISNSLRASYTAIATLTSSSIVPISHFEAFVARIAEVVKEAYTTAKFPSQQQAQGVPGDSSRNIVEQGILFGGPLPDVMAPAISRIFSEELPKLRAEIDPSRLFFHNFGILGLPDSNATVGRGATEGQAASTSSAQYRVNYTIDIFSRVPIQLGMEPEEGQGLDARRSRPGRRWRRCVRCAAAMEDIHSLTPPVQFLIMQQRRCYCGGNWDILAGARVVA
Length971
PositionTail
OrganismPseudogymnoascus sp. 23342-1-I1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.07
Grand average of hydropathy-0.107
Instability index44.22
Isoelectric point6.07
Molecular weight105562.63
Publications
PubMed=29295979

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09316
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.04|      45|      58|     272|     328|       1
---------------------------------------------------------------------------
  272-  328 (66.75/65.60)	SPAanpPDRPVN.PALnvvtPTII.IR..LLA.......DTNWMDG..SASDASDPFHlsPsmaALSHLS
  331-  388 (61.29/33.62)	SPS...PDGPGGrPTL....PTVItIRshLPNslsqynqDTHSLINrwELSEASPSVH..P...AFEQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.55|      21|      54|      42|      62|       2
---------------------------------------------------------------------------
   42-   62 (41.69/26.94)	GCCQSIAWSRWGS.IASITSNG
   97-  118 (34.86/21.24)	GQLKHLCWSPNGAdLAAIDAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.32|      45|     266|     186|     233|       3
---------------------------------------------------------------------------
  186-  233 (70.29/53.96)	IAFGpcFpNAHKSALITVGTNGVLSLLWPQADG..KWHELSSDIEGISTS
  463-  509 (79.03/47.72)	IGFT..Y.NGYEPSLVGALSPTHLSVVQKGCDGkiKWNPLVYNMGDIGTS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.08|      12|     266|     631|     648|       4
---------------------------------------------------------------------------
  631-  648 (16.89/21.79)	RVPIPdqqkkvLGLEDSE
  899-  910 (24.19/13.73)	RVPIQ......LGMEPEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.45|      34|      60|     724|     757|       5
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  724-  757 (56.75/30.79)	RLAHL...DYTARKAMSATHSASAPPGQSAPLISNSL
  784-  820 (51.70/27.45)	RIAEVvkeAYTTAKFPSQQQAQGVPGDSSRNIVEQGI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09316 with Med16 domain of Kingdom Fungi
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