<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09312

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDIGDYGTNVVCTYELNSIAYSYFESSSEAASVSTELYKLVAELQQLGLLAAKDNKKAGIWIFETGDTAGTSSGGAQLSGLASNLGIDLALKHNSSYDSNALLESWKSLSKPPPSTISSPSTDSGEPLSQKESFERHFRAAQAAVLNKEATAHNAVGLNNDAGSPNPTLKDRARQFQLLAQSRLRLHIHDYFLTAVFLSLGYALCLDHGYIPLSSRTLVVPKSNLATTGPYTSAQNSNGDMDNNLQLVTLSSDYTGSKVLVIKATLSTSTSYTACDLPRFVKHEDVPIPGNATLILGPGGSTGNYKGLASNGFQSTVSAYAPNVDETRHSGNEGQSSTSHQLRSRCLEWLVGKGINRERLENSAWFMVEIYLSQLINNPRQGPSEERVLIPWPSFLCFRQTDNTLSTNDAFGTLSTYDPLEFAHTWYAGQQDRDATIIRRRKEREAAEAVAKAQVDSEVQDLHSLYSPLTLRRSSVAGLVYPTPPDGVQQTVGATPTFDEAVSTPGQQGLPLSTDASSSLVAKVEADANAPVDMASHTDFDFQDTSNGNLFGDAGDDLFGEENDITDADFSFFDEPDIFQGNQDVDMPGQDKAAEVVENELPPSPKNDLNMGDDAEMADVHMGNTDESPVEESVPPDLPSDTNPARPMEIKPEASLEGPEISMDEPSPPLKPEYVFGRLSTFDVFSKPLLTKPQEDTSTVILNPAGAFGGVDFKAVFASLHQKYGSHGRFIYPHPRVSPNTLRAKFPTTDYFNRRRRRKLAGKSSIVRGVHTGSDHHFLVPGQATTFEQPAKQGLGSLSPPSDQDDSSDEMDGSFSHNSASLKRRHQIEDNSESNDDDEIASSFQELQVGHADETNNAALDTVYPFALDSDFARWSAAMFLAWPNPWANEYTLTDAEYIAAAQILGDQAISYTLRYPNDGNRRSVSLEEKIKATYTPNLIRQDVVQAAKKFFKGASSQTFSNFLDIQGVPRQLAGINRLPPRPVHSAPGSQGSQGSQGSQVSNPTKPNSLFPLPSPHLQLRRSESRLSVLPSALPFWDVLGLAPRGNGKHVTSLCVFPKAVGMAESADLFLENIRSAYETRRLGSHERLNTEGCVNGLLPIELGGQATRFASDQGLSVIREALFQVATLLSTSAADSTNFVVYFVYDPESPDMLVPICSAFHSMFEVYKTSMAGKTVSNELVLQLVPLNFVSARTHLVILPPTDYTRLAMEVYDRCFDFQAGVASPSVAIEPPLPRTIDFKLTANPSASLLQENSCLQIAYAQSIDDRWITAAWSDNTGSEQMTASYCLGRQDAPLTRQFSDIAHEIWETTLDIIASKKVHWRIIIAKCGVMESQDVRFWKGLSETERNAQISLTLLSVDTQPALQLLPPGLSIPASTLAAQSTFYTTPVSTPQPPSILSPDQSGGTPTATPTDGSGELKIEPDATLIDLTNQSYGAVLAHRVNNSNSPLEVRPTAISGYLVKRTGASSSDIPAIMEVNIVWTDINPRLAENPLKEILAWYSGLATLARARGIVDPVKDTRPWHIAAAEKAVRLLYLLM
Length1539
PositionKinase
OrganismPseudogymnoascus sp. 23342-1-I1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.08
Grand average of hydropathy-0.338
Instability index44.43
Isoelectric point4.99
Molecular weight167503.88
Publications
PubMed=29295979

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09312
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     560.54|     187|     226|     958|    1165|       1
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  958- 1165 (288.64/215.51)	QTFSNFLDIQGVPRQLAGINR....LPP........RPVHSAPGSQGSQGSQGSQVsNPTKPNSL.FPL...PSPHLQLRRSESRLSVLPSALPFWDVLGLAP.RGNGKHVTSLCVFPKAVGMAES.ADLFLENIRSAYETrrLGS...HERLNTEGCvnGLLPielgGQATRFAsdQGLS.VIREAlfQVA.TLLSTSAADSTNFVvyfvydPesPDMLVPICS.AFHSMF
 1175- 1385 (271.90/158.68)	KTVSNELVLQLVPLNFVSARThlviLPPtdytrlamEVYDRCFDFQAGVASPSVAI.EPPLPRTIdFKLtanPSASLLQENSCLQIAYAQSIDDRWITAAWSDnTGSEQMTASYCLGRQDAPLTRQfSDIAHEIWETTLDI..IASkkvHWRIIIAKC..GVME....SQDVRFW..KGLSeTERNA..QISlTLLSVDTQPALQLL......P..PGLSIPASTlAAQSTF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.78|      40|     226|      70|     116|       2
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   70-  116 (52.97/50.47)	GTSSGGAQlsGLASNlGIDLALkhnSSYDSNaLLESWKSLSKPPPST
  299-  338 (72.81/42.73)	GGSTGNYK..GLASN.GFQSTV...SAYAPN.VDETRHSGNEGQSST
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.45|      25|     221|     613|     646|       4
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  584-  610 (41.44/24.67)	DVDMPGQDKAAevVENELPPSPKNDLN
  619-  643 (47.01/24.02)	DVHMGNTDESP..VEESVPPDLPSDTN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     378.48|     121|     382|     384|     527|       8
---------------------------------------------------------------------------
  384-  515 (177.84/115.50)	SEERVLIPWPSfLCFRQtdntlSTNDAFGTLSTYDPLEFAHTWYAGQQDRDATIIRRRKE.REAAEAVAKAQVDSEVQDLHSLYSPLTlrRSSVAGLVYPTPPDGVQQTVGATpTFdEAVSTPGQQGLPLsTD
  774-  895 (200.65/100.46)	SDHHFLVPGQA.TTFEQ.....PAKQGLGSLSPPSDQDDSSDEMDGSFSHNSASLKRRHQiEDNSESNDDDEIASSFQELQVGHADET..NNAALDTVYPFALDSDFARWSAA.MF.LAWPNPWANEYTL.TD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.45|      17|      18|     656|     673|       9
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  656-  673 (29.15/20.10)	LeGPEISMDEPSPPL..KPE
  676-  694 (26.30/13.03)	F.GRLSTFDVFSKPLltKPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.94|      13|      27|     539|     553|      11
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  539-  553 (21.63/17.23)	DFDFQDtsNGNLF.GD
  569-  582 (22.31/11.02)	DFSFFD..EPDIFqGN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09312 with Med13 domain of Kingdom Fungi
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