<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09305

Description Uncharacterized protein
SequenceMSTRPPQPGPRPPQRSLSGTGMLQRQAQQRSHLQQTQQQQPSPGRASDSSAAAEAMADGVGAQMASPRLEPSKPGGSMVRVEGLTAQKQNIGSLGSPSSPAGTPGAVIMPLSQRGKPRFPFRRHEAQADAPKSVGSPQKSTANLPLPMPARPGRSGVSHVRKKAHDGGNSPKKETRPKPYVLEAPADAPSYPSNGHLDYFPWTGTHDEDRFNDSVIRQGHFDKPITGQNEAASAKQQLYPSLRQKNGLQTLGSLFAHVLGQRRQHSQITAAPSFKPPPRVTLTDTKRETWLRDLANPLIPLRRLSRTIPHGIKNKVLLEQCTRKNVPTERAVWLAKCVGANEIRASKRKGVPGALAMGGESKWIRDWTVCVEQFVDGVVTAGGDKDWKSKVLYSIRLSAHLYSEQLLDTEHYLDWLLSSLESTPLTRLPIWLLIAEVYWTDILRYRKSGRRLVAALCSNLQDAHESPDRDLLLPLIERVGNILTATVRTNPESFIALTNWPKYSDTLLACNTTGGPDDTQIFDTICRRNARLKSRSSSGDETQNSRRRVIDLLDASLSVQYSPDLSRECWKAMRDRALLVQTLFDWATSCARPSLMKTFVAARLMRTWSRHGVDVDESVLNYLTFRSNGSGVSTDAVYHLVSELARSGHFSVSKYIQWVIARGGLHGSQDVAADGPCVTRLLAELPVHDLPESLLRIRKTLLNRASFSVDHETETIDNMSLAFERCSPNLYGKAPSGEATPTTADVVQNIAHLSRTVKAELGLQLRRQINLRMSKASPSEVGEWKTDPEYETATTVTVADFNFTRAILEATEDLSMLADILKLVSTSSSTQILASIADTLNMHRLTFSAIGALGDLFDTLVSRQCSLGSIQGLESVVLLHSLCALSATIPDAQNVHVQLSRDVARSVRRSAVDACSPVSDHVAEALQKSDGDISDEVDKLLSSGTSMDAPTLKRLFQVLIGQMEASWAKPDLGLQRHGPILERLRTFDTKQFDNLLTPWVEQTILKSNRPDLGYVLGPLISAGCLSFKDVLKASVSSVQKTQDNGDKPTASRIAFESLSLVLNTYPDGDIMSVEDAYTLNIKRTQAQFKDHLAILKIGRTAIEISEPSVDNNDVTINLLCQGDAFRRFLQRLVLTEFDCVLYEFVTPLAKSQDLHIITCLRAILRGLLDLKTTTTGPEDLVVAKRIEVIFSVASDLTLPFCQLALRSLSASETPGSSEAAADTSRLEAFERAVDAALANGNPTWTKIIPTLDPQIAHHLCARAERALLSTIPAFKPSSSSPSPSPTTATNTTSTDTSDPTLAKSLLFVISATAHSNPNTTHTTALDIAEKLNTLAQALSQPQSTTEATYEATATWLPLMLEYITTHSETLSSASRPATDVRARVLLALSAVLLALHAHAGTHALAEHVLDVSLLLVDELPDDARAQCGRFLVEHGGGVVMGDPGVGYVFGLEREDGGLMISQRGKVEGFVVRRWECLSEPTPLVGENDAALSLSLFQARR
Length1500
PositionKinase
OrganismPseudogymnoascus sp. 23342-1-I1
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.05
Grand average of hydropathy-0.256
Instability index43.74
Isoelectric point7.60
Molecular weight163837.09
Publications
PubMed=29295979

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09305
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     280.38|      54|     174|      69|     123|       1
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   10-   68 (48.71/25.87)	.PR...PPQ....RSL.SGTGMLQRQAQQR..SHLQQT.Q.QQQPSPGrasdssAA.AEAMadgvgA.QM.......ASPR.....
   70-  123 (95.81/57.09)	EPS...KPG....GSM.VRVEGLTAQKQNI..GSLGSP.S.SPAGTPG......AV.IMPL.....S.QR.......GKPRFPFRR
  125-  161 (35.44/16.26)	....................E...AQADAP..KSVGSPqK.STANLP...........LPM.....P.AR......pGRSGVSHVR
  163-  211 (47.74/25.17)	.KA...HDG....GNS.PKKE..TRPKPYVleAPADAP.S.YPSN..G......HLdYFPW.....TgTH.......DEDRF....
  239-  303 (52.69/30.15)	YPSlrqKNGlqtlGSLfAHVLGQRRQHSQI....TAAP.SfKP...PP......RV.TLTD.....T.KRetwlrdlANPLIPLRR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.07|      29|      37|     798|     833|       2
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  798-  829 (41.85/36.53)	VAD.FNFTRAILEAtedLSMLADIL.KLVSTSSS
  836-  866 (42.22/19.96)	IADtLNMHRLTFSA...IGALGDLFdTLVSRQCS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.78|      22|      38|    1265|    1288|       3
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 1265- 1288 (34.35/27.20)	RALLSTIPAfkPSSSSPSPSPTTA
 1303- 1324 (38.43/23.35)	KSLLFVISA..TAHSNPNTTHTTA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.34|      27|      38|     947|     981|       4
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  947-  973 (47.90/21.58)	MDAPTLKRLFQVLIGQMEASWAKPDLG
  987- 1013 (45.44/31.31)	FDTKQFDNLLTPWVEQTILKSNRPDLG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     247.16|      70|     175|     875|     944|       7
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  516-  570 (66.74/39.19)	.................PDDTQIFDTICRRNARlKSRSSSGDETQNSRRRVIDLL....DAS.LS.VQYSPDLSreCW
  576-  637 (68.10/40.16)	RALLVQTLFdwATSCARPSLMKTFVA.AR.LMR.TWSRHGVD....VDESVLNYLTfRSNGSgVStDAV.........
  875-  944 (112.32/71.46)	SVVLLHSLC..ALSATIPDAQNVHVQLSRDVAR.SVRRSAVDACSPVSDHVAEALQ.KSDGD.IS.DEVDKLLS..SG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.58|      37|      40|    1159|    1198|       8
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 1159- 1198 (47.59/44.27)	CLRAiLRGlLDLKTTTTGPEDLVVAKRIEViFSVASDLTL
 1201- 1237 (59.99/39.78)	CQLA.LRS.LSASETPGSSEAAADTSRLEA.FERAVDAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.21|      36|      40|     709|     745|       9
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  709-  745 (57.60/40.41)	VDHETETID.NMSLAFERcSPNL.YGKAPSGEATPTTAD
  750-  787 (51.61/30.43)	IAHLSRTVKaELGLQLRR.QINLrMSKASPSEVGEWKTD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09305 with Med12 domain of Kingdom Fungi
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