Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MSSELDKQPTSSKHLTKAERIQQLNEIDQSITKLLGSAGLAVKTLTSINSPSETTSAGRREAFTAATDTYLKDLHSVDVRLKRQIKGLDDAGVIKAEPETEEEGDKGKQAPETKNGAIDVGWLNTRSNKVGRDMEAELWEKARNFLDGLEAKKPGGSLTAQDGRGAEARGESNGDVMDTS |
Length | 180 |
Position | Head |
Organism | Pseudogymnoascus sp. 23342-1-I1 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.823 |
Instability index | 38.74 |
Isoelectric point | 5.23 |
Molecular weight | 19413.25 |
Publications | PubMed=29295979 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP09300 No repeats found |
MoRF Sequence | Start | Stop |
1) ELDKQP 2) GRGAEARG 3) IKAEPETE 4) RDMEAELWEKARNFLDGLEAKKPGGSL 5) RLKRQI | 4 163 94 132 80 | 9 170 101 158 85 |
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