<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09296

Description Uncharacterized protein
SequenceMSTRPPQPGPRPPQRSLSGTGMLQRQAQQRSHLQQSQQPSPGRTSDSAVEAIADGAETAPPRLEPSKPGGSMVRVEGLPAQKQNIVSMESPSQAGTPGAVMPLPKRARQRVPFRRHEAQSDAPKQVGSPQKSSVNLPLPMPARPGRSGVSHIRKQAHDAGNSPKKETRPKPYVLEAPPDAPSYPPNGHLDYFPWAGTHNEDTFNDSVIRQGYFDKIQTGQNETASAKQQLYPLLRQKNGLQTLGSLFAHVLGQRRQHSQITAAPSFKPPPRVTLTDTKRETWLRDLANPLIPLRRLSRTIPHGIKNKVLLEQCTRKNVPTERAVWLAKCVGANEIRASKRKGVPGALAMGGESKWIRDWTVCVEQFVDGVVAAGGDKDWKSKVLYSIRLSAHLYSEQLLDTEHYLDWLLSSLESTPLTRLPIWLLIAEVYWADILRYRKSARRLVAALCSNLQDAHESPDRDLLLPLIERVGNILTETVRTNPESFIALSHWPKYSDTLEACNTSGGPDETKLFDAISRRNARLKSRSSGGDETQNSRRRVIDLLDASLSVQFSPDLSRECWKGMRDRTLLVQTLFDWATSCARPSLMKTFVAARLMRTWSRHGVDVDESVLNYLTFRSNGPGVSGDAVYHLVSELARSGHFSVSKYIQWVIARGGLHGSQDVAADGPCVTRLLAELPVHDLPENLLRIRKTLLNRASFSVDDETETINNMSLAFERCSPNLYGKAPSGEEAPTTAEVVQNITHLSRTVKAELGLRLRKQINLRMTKVSPSEMGEWKADPEYESATTVTVADFNFARAVLEATEDLSMLADILKLVSSSSSTQILASIADTLNMHRLTFSAIGALTDLFDTLVSRQCSLGPIQGPESVTLLHSLCALSATIPDAANVHVQLSRDVARSVRRSAVDACSPVSDHVAEALQKSDGDISDEVDKLLSSGTSMDAPTLKRLFQVLINQMEASWVKSDSGLQKHGQILERLRTFDTKQFDNLLTPWVEQTILKSDRPNLSHVLGPLVSASCLSFKDVLKASVSSVQKTRDDGDKPTTSGISFESLSLVLNTYRDGDIMSVEDAYTLNIKRTQAQFKDHLAILKIARIAIEISEPSVDNNDVTINLLCQGDAFRRFLQRLVLTEFDCVLREFVTPLAKSQDFHIITCLRAILRGLLDLKTTTTGPEDLVVARRIEVIFGVASDLTLPFCQLALRSLSASETPGSSSEAAADTSRLEAYERAVDAALANNNPTWTKIIPTLDPQIAQHLCDRAERSLLDTIPTFKPPSSDSPAPPKPLSDPALAKRMLLVISATAYSTQNLGHTTALEIGEKINNLAHALSQPPTTETYSQTTTWLPLMLEYITTHASTLPASRPATDVRARVLLALSALMLALHAHTGTDALSEHVLDVSLLLVDELPDDARAQCGRFLSERGKEVVLGDPGLRYVFGLETGGAGDGAGGGGGGGGGTLMISQRGRMEGFVVRRWECLSEPTPLVGENDAALSLSLFQARR
Length1495
PositionKinase
OrganismPseudogymnoascus sp. WSF 3629
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.05
Grand average of hydropathy-0.298
Instability index47.34
Isoelectric point7.80
Molecular weight163906.36
Publications
PubMed=29295979

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP09296
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1038.90|     282|     302|     396|     696|       1
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  143-  382 (268.93/181.78)	..............................................RPGRS..GVSHIRKQAHDAGNSPKKE................T.......RPKPY....VLEAPPDAPSYppnghldyfpwagthnEDTFNDS.VIRQG.....YFDKI..........QTGQNETASAKQQLYPLLRQKNGLQTLGSLFAHV....LGQRRQHSQITAApSFKppprvtltdtkretWLRDLANP.LIPL....RR.LSRTIP.HGIK.....NKVLLEQCT.RKNVP..TERAVW.....LAKcvganEIRASKRKGVP.........GALAMGG....ESKWIRDWTVCVEQfvdgVVAAGGDKDWK...............SK
  396-  696 (456.00/365.80)	EQLLD.TEHYLDWLLSSLESTP..LTRLPiwlliaevywadilryrKSARR..LVAALCSNLQDAHESPDRDLLLPLIERVGNILTETV.......RTNPE....SFIALSHWPKY................SDTLEAC.NTSGGPDETKLFDAISRRNArLKSRSSGGDETQNSRRRVIDLLDASLSVQFSPDLSREC....WKGMRDRTLLVQT.LFD..............WATSCARPSLMKTFVA.AR.LMRTWSRHGVD....VDESVLNYLTfRSNGPGVSGDAVYHLVSELAR.....SGHFSVSKYIQ.........WVIARGGL..HGSQDVAADGPCVTR....LLAELPVHDLP..ENLLR..IRKTLLNR
  699-  997 (313.98/219.67)	FSVDDeTETINNMSLAFERCSPnlYGKAP..................SGEEapTTAEVVQNITHLSRTVKAELGLRLRKQINLRMTKVSpsemgewKADPEyesaTTVTVADFNFA................RAVLEATeDLSMLADILKLVSSSSSTQI.LASIA....DTLNMHRLTFSAIGA.LTDLFDTLVSRQCslgpIQGPESVTLL.HS.LC................ALSATIPDAANVHVQlSRdVARSVRRSAVDacspVSDHVAEALQ.KSDG.DIS.DEVDKLLSSGTS.....MDAPTLKRLFQvlinqmeasWVKSDSGLqkH........G....Q....ILERLRTFDTKqfDNLLTpwVEQTIL..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.25|      24|      53|       5|      29|       2
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    5-   28 (44.87/20.43)	PPQPGPRPPQRSLSGTGMLQRQAQ
   39-   57 (22.79/ 8.02)	.....PSPGRTSDSAVEAIADGAE
   60-   83 (41.59/18.13)	PPRLEPSKPGGSMVRVEGLPAQKQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.32|      16|      34|      89|     104|       3
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   89-  104 (31.81/20.66)	ESPSQAGTP..GAV.MPLP
  121-  139 (21.51/11.08)	DAPKQVGSPqkSSVnLPLP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.61|      34|      38|    1156|    1190|       4
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 1156- 1190 (49.70/39.77)	LRGLLDLKTTTTGPEDLVVARRIEViFGVASDLTL
 1197- 1230 (52.91/37.29)	LRSLSASETPGSSSEAAADTSRLEA.YERAVDAAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09296 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSTRPPQPGPRPPQRSLSGTGMLQRQAQQRSHLQQSQQPSPGRTSDSAVEAIADGAETAPPRLEPSKPGGSMVRVEGLPAQKQNIVSMESPSQAGTPGAVMPLPKRARQRVPFRRHEAQSDAPKQVGSPQKSSVNLPLPMPARPGRSGVSHIRKQAHDAGNSPKKETRPKPYVLEAPPDAPSYPPNGHLDYFPWAG
1
196










Molecular Recognition Features






MoRF SequenceStartStop




1) GAVMPLPKRARQRVPFRRHE
2) HIRKQAH
98
151
117
157