<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09295

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDIGDYGTNVVCTYELNSIAYSYFECPSEATSVSTELYKLVAELQQLGLLAAKDNKKAGLWIFETGDNSEPASSPSGGAQLPGLASNLGIDLALKHSGSYDSNALLESWKSLSKPPTNTISSPSTESSEPLSQKESFERHFRAAQAAIMNKEASVNNSLIGLNNDAGTLNPTLKDRARQFQLLAQSRLRLHIHDYFLTAVFLSLGYALCLDHGYIPLSSRTLVVPKSNLATTGSQTTAQSNNGITDDRLQLVTLSSDYTGSKVLVIKATLSTSTSYTSCDLPRLVKHEDVPIPANATLILGPGGSTGNFKGLANNGFQSTVSTYATGSDEAQHPGNEGPSSTSHRLRSRCLEWLVGKGINRELLENSAWFMVEIYLNQLTNIPRQGPSEERVLIPWPSFLCFRQTDNTLSTNDAFGTLSTYDPLEFAQTWYAGQQDRDATIIRRRKEREAAEAVAKAQADSEAQDLHSLYSPLALRRSSVAGLVYPTPPDGVQHTVGATPTFDEAVSTPGQQGLPLSTDASSALVAKTEADANGPLDIASHTDFDFQDTSNGNLFGDAGDDLFGEENDITDADFSFFDEPDIFQGNQDVEMPGQDNTAEVVENELALGPKDDLNMGDVPEMADVHMGNTDESPVEESLPPDLPSDTNPARQIEIKTEASLEGPEASTDEPSPPLKPEYVFGRLSTFDVFSKPLLTKPQEDTSTVILNPAGAFGGVDFKALFASLHQKYGTHGRFIYPAPKVSPNTLRAKFPTTDYFNRRRRRKLAGKSSIVRGVHTGSDHHFLVPGQTINFEQPAQRGSRSPSPSSDQDGSSDEMDGSYSHNSASLKRRHQVEDSESNDDEEITSSFQELQVGQADETNNAALDTVYPFALDSDFGRWSAAMFLAWPNPWANEYTLTDAEYIAAAQILGDQAISYTLRYPNDGNRHSGSLEENIKATYTPDLIRQDVVQAARKYFKGANPQTLSNFLDIQGVPRQLAGINRLPPRPVPSSQGSQGSQGSNPAKPNPIFPLPSPHLQLRRSDFRLSVLPSALPFWDVLGLAPRGNGKHVTSLCVFPKAVGMAESTDLFLENIRSAYETRRLGSHERLNTEGCVNGLLPIELGGQATRFSSDQGLSVIREALFQVANLLASSPADSTNFVVYFVYDPESPDILVPICSAFHSMFEVYKTAMAGKTVSNELVLQLVPLNFVSARTHLVVLPPTDYTRLAMEVYDRCFDFQAGVASPSVAIEPPLPRTIDFKLTLNPSASLLQENSCLQIAYAQSIDDRWITAAWSDNTGSEQMTASYCLGRQDAPLTRQFSDIAHEIWETTLDIIASKKVHWRIIIAKCGVMEAQDVRFWKGLSETERNAQISLTLLSVDTQPALQLLPPGLSIPASTLAAQSTFYTTPVSTPQPASILSPDQSGGTPTATPTDGTGELKIEPDATLIDLTNQSYGAVLAHRVNNSNSPLEVRPTAISGYLLKRTGASSSDVPAVMEVNIVWTDINPRLAENPLKEILAWYSGLATLARARGIVDPVKDTRPWHIAAAEKAVRLLYLLM
Length1536
PositionKinase
OrganismPseudogymnoascus sp. WSF 3629
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.08
Grand average of hydropathy-0.337
Instability index45.13
Isoelectric point4.90
Molecular weight167191.53
Publications
PubMed=29295979

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09295
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.30|      24|     205|     955|     984|       1
---------------------------------------------------------------------------
  961-  984 (43.61/32.28)	QTLSNFLDIQGVPRQLAGINR....LPP
 1172- 1199 (35.69/13.53)	KTVSNELVLQLVPLNFVSARThlvvLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      13|     205|    1018|    1030|       2
---------------------------------------------------------------------------
 1018- 1030 (23.61/15.50)	RRSDFRLSVLPSA
 1233- 1245 (23.79/15.68)	RTIDFKLTLNPSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.20|      57|     205|     282|     392|       3
---------------------------------------------------------------------------
  300-  357 (99.94/128.01)	LGPgGSTGNFKGLANNGFQS.TVSTYATG.SDEA.............QHPGNEGPSSTSHRLRSRCLEWLVGK
  783-  854 (83.26/27.41)	LVP.GQTINFEQPAQRGSRSpSPSSDQDGsSDEMdgsyshnsaslkrRHQVEDSESNDDEEITSSFQELQVGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.82|      17|      19|     594|     612|       4
---------------------------------------------------------------------------
  596-  612 (27.92/24.75)	NTAEVVE.NELALGPKDD
  614-  631 (26.90/14.36)	NMGDVPEmADVHMGNTDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     232.73|      75|     540|     111|     197|       5
---------------------------------------------------------------------------
  111-  197 (104.46/73.25)	SLSKPPTNTisspsTESSEPLSQKESFER..HFRAAQAAIMNKEASvNNSLIGLnNDAGTLNPTlkDRARQFQLLAQsrlRLHIHDYFL
  659-  735 (128.27/61.68)	SLEGPEAST.....DEPSPPLKPEYVFGRlsTFDVFSKPLLTKPQE.DTSTVIL.NPAGAFGGV..DFKALFASLHQ...KYGTHGRFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.31|      52|     814|     509|     565|       6
---------------------------------------------------------------------------
  433-  492 (77.32/40.88)	GQQDRDATiirrrkeREAAEA.VAKAQADSEAQ.DLHSlYSPLALRRSSVAGLVYPTPPD..GV
  510-  565 (76.99/57.57)	GQQGLPLS.......TDASSAlVAKTEADANGPlDIAS.HTDFDFQDTSNGNLFGDAGDDlfGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.60|      23|     816|      59|     103|       7
---------------------------------------------------------------------------
   81-  103 (38.15/12.93)	LPGLASNLGIDLALKHSGSYDSN
 1113- 1135 (35.45/20.75)	LSVIREALFQVANLLASSPADST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.52|      15|     345|     928|     946|      19
---------------------------------------------------------------------------
  928-  946 (18.26/23.51)	GSleENIKATYTpdLIRQD
 1276- 1290 (30.25/18.80)	GS..EQMTASYC..LGRQD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09295 with Med13 domain of Kingdom Fungi
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