<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09286

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGYGTGAHTNHDRDGAPNGTNGALQASSRPAEKTGMPGHQQPPNQSVQLNGANGASMTQSAGHPAGSVSKDANIQTKSTPPEINHITEGFESLPNLLTRLAQVTHNQLSGKLLELAGMNIQQSPDNSNAVSFVSSPDDNSAENIKKKVNLLKFAEGVHSNWTKALVITQWSRISEEVSRVIDLKAHLDEQKLYYDIAVHELSEVKRSLVHARLPNPDLRTAVEVLSTGKASWMPDLGYIEPPPLTAKEILQSLQNLNTLLSIRLNLHDYDKIPYHFRNYTIKSGRVTFRVEGEFEVDLTIADEDPEKQFWFIDFRFLFSPSPSALTDQMRFSLEAKVNTVLEKDGLAGCYKVLHDLTLTHKISELRRQAYEIGRSRWIDTLMVEPLRRSLSIQYWVDRYGKDGPKSWIIIGVVSGKKKGAYPDEKETSQIGIRWFRDSKEVKDAEIPLELTTLSLEGLLRSVITLHVSHILESMYKSLRTKPLYENRDLVLSFKKPTAAEQEPELHVQLTSQYKINVIVEYITGKFAISPSSRLTSQAEYRLNNQTVDPASNGHEYLENLHCVLISEDTVNRAYTVGWLPVRNPRLPQDELKPFLPRDTLQLSWFKKPGWDPNWYLALSSGMSGERWWLIEITNVPEGPRPAADSIVLDGPTVRSHIQLPLKSVSPAPTYAFLSSLHLLSTSMISYYTNMRALHSRRAKFMLRNPPKSTLSSRQGQPSLYIMLSTLLPSKNRSPRTGKPWAKDVLKVSFQGIETLEQKEAATSPAGGSSQSLSNPPSAPSGPVGPRQSDTEEGAIMIAEGHMETAIPAGLLVKQHVDKDIAFHPSTSAFAFRLQAKVGEPTITPLIERLQRVERLVDFVQVINAHPDSLHCESVSLSRLIFSYGCVQSPGPNQPHTESPRYQAIIDFSSQTTKLELQLEAGNPHIRILDHLTKILNSPLGLHGLATILPLTLPVLRALDAAEDSWEDIPSSELQILCRAADWYAVRYNLTPPSDGDNKSPAPPERIVFEIRLHRRGNVPWWCMRRDQKHNAATVDPLDLALKEKVWTGSEKGVWMGLQCAAIAQTGGAEAMVLRVDSAMRDLAKDGTVFASAAPGVAGVKGEGAAAEMTDVLGGQIGQAQAQAVNAPNKAQPQRPQTKSPVLQKQVQKKAQGPPTQQQRTQAALNEAQHRAQYQAQQLARQKEMHRQAQVQARQGQGQQRPNANNANGGNGNSGKQDAIVID
Length1224
PositionTail
OrganismPseudogymnoascus sp. WSF 3629
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.06
Grand average of hydropathy-0.463
Instability index46.87
Isoelectric point8.33
Molecular weight135607.04
Publications
PubMed=29295979

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09286
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.32|      31|      35|    1122|    1153|       1
---------------------------------------------------------------------------
 1122- 1153 (49.16/37.83)	QAQAVNAP.NKAQpQRPQTKSPVL..QKQVQKKAQ
 1158- 1191 (46.16/29.56)	QQQRTQAAlNEAQ.HRAQYQAQQLarQKEMHRQAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.14|      14|      35|      20|      33|       2
---------------------------------------------------------------------------
   20-   33 (26.43/16.37)	NGTNGA..LQASSRPA
   52-   67 (22.71/12.91)	NGANGAsmTQSAGHPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.77|      22|      27|     199|     225|       3
---------------------------------------------------------------------------
  203-  225 (32.56/27.78)	LSEVKRSLVH..ARLPNPDLrTAVE
  227-  250 (34.20/14.41)	LSTGKASWMPdlGYIEPPPL.TAKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.91|      29|      32|     551|     582|       4
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  553-  582 (46.84/40.21)	SNGHEYLENLHcVLISEDTVNRAY..TVGWLP
  584-  614 (51.07/30.02)	RNPRLPQDELK.PFLPRDTLQLSWfkKPGWDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.14|      33|      35|    1022|    1054|       5
---------------------------------------------------------------------------
  984- 1021 (45.08/29.28)	WY....AVRYNltppsDGDNK.SPAPPERIVFEI.....RLHRRGNVP
 1022- 1054 (57.82/39.89)	WW....CMRRD.....QKHNA.ATVDPLDLALKE.....KVWTGSEKG
 1055- 1097 (34.23/20.25)	VWmglqCAAIA.....QTGGAeAMVLRVDSAMRDlakdgTVFASAAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.80|      10|      37|     467|     478|       7
---------------------------------------------------------------------------
  467-  478 (14.49/14.17)	LHVShiLESMYK
  507-  516 (19.31/10.56)	LHVQ..LTSQYK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.31|      23|      27|     872|     897|       8
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  874-  897 (39.48/34.56)	ESVSLSRLI.FSYGC....VQSPGPNqPH
  899-  926 (31.83/14.45)	ESPRYQAIIdFSSQTtkleLQLEAGN.PH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.31|      17|      19|     703|     719|      11
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  703-  719 (32.11/19.59)	MLRN.PPKSTLSSRQGQP
  724-  741 (27.21/15.32)	MLSTlLPSKNRSPRTGKP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.69|      12|      14|     661|     672|      12
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  661-  672 (22.01/13.26)	LPLKSVSPAPTY
  678-  689 (21.69/12.95)	LHLLSTSMISYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.61|      11|      14|     826|     836|      17
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  826-  836 (19.26/11.57)	PSTSAFAFRLQ
  842-  852 (19.36/11.67)	PTITPLIERLQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09286 with Med14 domain of Kingdom Fungi
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