<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09283

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSSTISRTVQGPAMADTHDSATPMSIDSSIQADDLSNKRKRESEDTGDREQKKAHVEERKLCIEDLHLDVGKIYQLCRTPHPYKQPDSGLDLFELYGLNPTAAKVARVLPSGEKNGLRKTYKGKIKDLGISGKFDVTVNDEESSGGLLSMMREPEHEWMVTQRLGKEIEKGLPQNVFAALPAAMTMAKGVIPKQMWDSSVLGELDIPEKKAAAQVPSKPTSAGMQKTASQQSGAMSRGSKADLARPKRAVKKRGYDESSFEGYGEGYVDDDMVDAGYSTGEGDDRGGPGKRRKKSALNQQQYGPSRHGSYGPGMVGA
Length317
PositionHead
OrganismPseudogymnoascus sp. WSF 3629
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus> unclassified Pseudogymnoascus.
Aromaticity0.05
Grand average of hydropathy-0.809
Instability index40.24
Isoelectric point8.29
Molecular weight34453.36
Publications
PubMed=29295979

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP09283
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.27|      10|      20|      65|      74|       1
---------------------------------------------------------------------------
   65-   74 (18.30/12.48)	DLHLDVGKIY
   87-   96 (17.97/12.14)	DSGLDLFELY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.32|      43|     168|      12|      54|       2
---------------------------------------------------------------------------
   12-   54 (73.04/48.63)	PAMADTHDSATPMSI.DSSIQAD.DLSNKR...KRESEDTGDREQKKA
  181-  228 (60.28/38.86)	PAAMTMAKGVIPKQMwDSSVLGElDIPEKKaaaQVPSKPTSAGMQKTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.84|      17|      17|      97|     113|       3
---------------------------------------------------------------------------
   97-  113 (28.74/16.69)	GLNPT.AAKVARVLPSGE
  116-  133 (24.11/13.04)	GLRKTyKGKIKDLGISGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.16|      24|      45|     245|     268|       5
---------------------------------------------------------------------------
  245-  268 (44.30/20.11)	RPKRAVKKRGYDESSFEGYGEGYV
  292-  315 (45.86/21.01)	RKKSALNQQQYGPSRHGSYGPGMV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09283 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DMVDAGYSTGEGDDRGGPGKRRKKSALNQQQYGPSRHGSYGPGMVGA
2) IPEKKAAAQVPSKPTSAGMQKTASQQSGAMSRGSKADLARPKRAVKKRGYD
3) MSSTISRTVQGPAMADTHDSATPMSIDSSIQADDLSNKRKRESEDTGDREQKKAHVEE
271
206
1
317
256
58










Molecular Recognition Features






MoRF SequenceStartStop




1) DDMVDAGYSTG
2) GPGKRRKKSALNQQQYGPSRHGSYGPGMVGA
3) LDLFELY
270
287
90
280
317
96